期刊
INTERNATIONAL JOURNAL OF SURGERY
卷 104, 期 -, 页码 -出版社
ELSEVIER
DOI: 10.1016/j.ijsu.2022.106751
关键词
Colorectal cancer; Gut microbiota; Colorectal surgery; Anastomotic leak; Nutritional therapy
类别
资金
- Institute of Health Carlos III (ISCIII)
- Fondo Europeo de Desarrollo Regional-FEDER [PI20/00505]
- ISCIII, Spain [INT21/00078]
- Fondo Europeo de Desarrollo Regional-FEDER
- PFIS doctoral fellowship (ISCIII, Spain) [FI21/00003]
- PFIS doctoral fellowship (Fondo Europeo de Desarrollo Regional-FEDER)
- Miguel Servet Type I'' program (ISCIII, Spain) [CP19/00098]
- Miguel Servet Type I'' program (Fondo Europeo de Desarrollo Regional-FEDER)
This article reviews the role of the gut microbiota in complications of colorectal cancer surgery and explores the potential therapeutic modulation of the gut microbiome through nutritional intervention in patients with colorectal cancer undergoing surgery.
Colorectal cancer (CRC) is the third most frequent malignancy and the second cause of cancer death worldwide. Several factors have been postulated to be involved in CRC pathophysiology, including physical inactivity, unhealthy dietary habits, obesity, and the gut microbiota. Emerging data suggest that the micmbiome may play a key role in CRC prognosis and derived complications in patients undergoing colorectal surgery. On the other hand, dietary intervention has been demonstrated to be able to induce significant changes in the gut microbiota and related metabolites in different conditions; therefore, the manipulation of gut microbiota through dietary intervention may constitute a useful approach to improve perioperative dysbiosis and post-surgical outcomes in patients with CRC. In this article, we review the role of the gut microbiota in CRC surgery complications and the potential therapeutic modulation of gut micmbiome through nutritional intervention in patients with CRC undergoing surgery.
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