期刊
EUROINTERVENTION
卷 18, 期 3, 页码 235-+出版社
EUROPA EDITION
DOI: 10.4244/EIJ-D-21-00867
关键词
cost-effectiveness; fractional flow reserve; multivessel disease; myocardial infarction; STEMI
This study evaluated the cost-effectiveness and cost-utility of FFR-guided PCI as the secondary endpoint of the FLOWER-MI trial. The results showed that FFR-guided strategy is unlikely to be cost effective compared to angiography-guided strategy in terms of clinical and quality of life outcomes after one year.
Background: In patients with ST-segment elevation myocardial infarction (STEMI) who have multivessel disease, the FLOWER-MI trial found no significant clinical benefit to fractional flow reserve (FFR)-guided percutaneous coronary intervention (PCI) compared to angiography-guided PCI. Aims: Our aim was to estimate the cost-effectiveness and cost-utility of FFR-guided PCI, the secondary endpoint of the FLOWER-MI trial. Methods: Costs, major adverse cardiovascular events (composite of all-cause death, non-fatal myocardial infarction [MI], and unplanned hospitalisation leading to urgent revascularisation), and quality-adjusted life years were calculated in both groups. The incremental cost-effectiveness and cost-utility ratios were estimated. Uncertainty was explored by probabilistic bootstrapping. The analysis was conducted from the perspective of the health care provider with a time horizon of one year. Results: At one year, the average cost per patient was 7,560 euro (+/- 2,218) in the FFR-guided group and 7,089 euro (+/- 1,991) in the angiography-guided group (p-value<0.01). The point estimates for the incremental cost-effectiveness and cost-utility ratios found that the angiography-guided strategy was cost saving and improved outcomes, with a probabilistic sensitivity analysis confirming dominance. Conclusions: The FFR-guided strategy at one year is unlikely to be cost effective compared to the angiography-guided strategy on both clinical and quality of life outcomes.
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