4.7 Review

Recent Advances in Nano-Formulations for Skin Wound Repair Applications

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Article Endocrinology & Metabolism

IDF Diabetes Atlas: Global, regional and country-level diabetes prevalence estimates for 2021 and projections for 2045

Hong Sun et al.

Summary: This study provides global, regional, and country-level estimates of diabetes prevalence and health expenditures for 2021 and projections for 2045. The global prevalence of diabetes is increasing and is expected to have the greatest relative increase in middle-income countries. Diabetes-related health expenditures are also projected to rise.

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Zinc-Based Metal-Organic Frameworks in Drug Delivery, Cell Imaging, and Sensing

Rashda Safdar Ali et al.

Summary: Metal-organic frameworks (MOFs) are a new class of porous materials with excellent biocompatibility, easy functionalization, high storage capacity, and excellent biodegradability. They are extensively used in drug delivery systems, cell imaging, and chemosensory due to their versatile porous structure and chemical composition, allowing for engineering improvements in medical formulation and functionality.

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Article Chemistry, Multidisciplinary

Effective Inhibition of Invasive Pulmonary Aspergillosis by Silver Nanoparticles Biosynthesized with Artemisia sieberi Leaf Extract

Enas M. Ali et al.

Summary: In this study, the antifungal effect of silver nanoparticles biosynthesized with Artemisia sieberi leaf extract (AS-AgNPs) against Aspergillus fumigatus was investigated. The AS-AgNPs showed significant antifungal activity and inhibited the growth of hyphae. They also exhibited low cytotoxicity on human lung cells. In a mouse model, AS-AgNPs effectively reduced lung tissue damage, suppressed the levels of pro-inflammatory cytokines, and decreased oxidative stress. The findings suggest that AS-AgNPs have therapeutic potential as an alternative treatment for aspergillosis.

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Review Engineering, Biomedical

A short review on chitosan and gelatin-based hydrogel composite polymers for wound healing

Samuel Ogbeide Ebhodaghe

Summary: This review examines the modification of chitosan and gelatin-based hydrogel composite polymers for wound healing. Different techniques for improving the mechanical properties of these polymers are discussed and compared. The article also summarizes research on gelatin-based hydrogel polymeric systems and adhesive anti-biofilm hydrogels. The importance of studying specific biological macromolecule-based composites such as chitosan and gelatin is highlighted.

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Article Chemistry, Physical

Silver nanoparticles with vanadium oxide nanowires loaded into electrospun dressings for efficient healing of bacterium-infected wounds

Lei Huang et al.

Summary: This study successfully prepared silver nanoparticles/vanadium oxide nanowires via a one-step reduction strategy, which exhibited remarkable antibacterial effects on textiles and had the potential for wound healing application.

JOURNAL OF COLLOID AND INTERFACE SCIENCE (2022)

Review Infectious Diseases

Functionalized carbon-based nanomaterials and quantum dots with antibacterial activity: a review

Mehran Alavi et al.

Summary: The emergence of antibiotic resistance in bacteria, especially in treating infectious immunodeficiency related diseases, is a complex issue. Nanomaterials (NMs) have played a novel role in treating bacterial infections compared to bulk materials. Carbon-containing quantum dots (QDs) like graphene oxide QD (GOQD), graphene QD (GQD), and carbon QD (CQD) have shown bacteriostatic and bactericidal activities against antibiotic-resistant bacteria. The stability and biocompatibility of QDs at higher doses in physiological conditions are major concerns, which can be addressed through functionalization. Additionally, the aspect ratio (AR) of carbon nanotubes (CNTs) like single-wall carbon nanotubes (SWCNTs) and multiwall carbon nanotubes (MWCNTs) is a determining factor for antibacterial value, with SWCNTs showing higher antibacterial ability than MWCNTs.

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Article Dermatology

Self-Assembled Nanomaterials for Chronic Skin Wound Healing

Hwan June Kang et al.

Summary: Chronic wounds are a significant burden on the U.S. health care system, requiring more effective treatments. Self-assembled nanomaterials offer new therapeutic options, but customization is needed to address different types of chronic wounds. Future studies should explore combinations of self-assembled nanomaterials to fully utilize their multifunctional properties.

ADVANCES IN WOUND CARE (2021)

Article Dermatology

Approaches to Modulate the Chronic Wound Environment Using Localized Nucleic Acid Delivery

Adam G. Berger et al.

Summary: Despite new understanding in the biology of impaired wound healing, little progress has been made in treating chronic wounds. Diabetic ulcers are a common form of nonhealing wounds. Recently, research on therapeutic nucleic acids has shown promise in creating a new treatment strategy for chronic wounds.

ADVANCES IN WOUND CARE (2021)

Review Pharmacology & Pharmacy

Electrospun nanofiber-based drug delivery platform: advances in diabetic foot ulcer management

D. R. Madhukiran et al.

Summary: Electrospinning is a convenient method for fabricating nanofibers, with great potential in delivering drugs or therapeutic molecules to wound sites, especially in the treatment of diabetic foot ulcers. This review discusses the evolution of electrospinning techniques, various types of electrospun nanofibers used for DFU or chronic diabetic wounds, challenges in nanofiber preparation, and methods for evaluating their efficacy in diabetic wound healing. Expert opinions suggest that electrospinning-based nanofibers are safe, effective, and multifunctional for managing DFUs.

EXPERT OPINION ON DRUG DELIVERY (2021)

Article Dermatology

Comparison of mechanical, chemical and physical human models of in vivo skin damage: Randomized controlled trial

Dario Leskur et al.

Summary: The study aimed to compare skin parameters in three different skin damage models on the same anatomical location, with and without topical treatment. The results showed that sodium lauryl sulphate irritation caused the most severe damage with a delayed reaction, while tape stripping initially led to the highest skin barrier disruption but showed the fastest recovery. Ultraviolet radiation did not affect skin barrier function but increased skin erythema and melanin levels.

SKIN RESEARCH AND TECHNOLOGY (2021)

Review Microbiology

Nanomaterial-based therapeutics for antibiotic-resistant bacterial infections

Jessa Marie V. Makabenta et al.

Summary: Nanomaterial-based therapies offer a promising approach to combat antibiotic-resistant bacterial infections by targeting biofilms and overcoming recalcitrant infections. Their unique size and physical properties enable them to evade existing mechanisms associated with acquired drug resistance.

NATURE REVIEWS MICROBIOLOGY (2021)

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Nanomaterials arising amid antibiotic resistance

Weiwei Gao et al.

NATURE REVIEWS MICROBIOLOGY (2021)

Article Nanoscience & Nanotechnology

Mussel-Inspired Surface Immobilization of Heparin on Magnetic Nanoparticles for Enhanced Wound Repair via Sustained Release of a Growth Factor and M2 Macrophage Polarization

Jiang Wu et al.

Summary: The study developed bFGF-HDC@Fe3O4 nanoparticle to stabilize and sustainably release bFGF, accelerating wound healing through promoting macrophage polarization and cell proliferation. In vitro and in vivo experiments showed promising results in accelerating wound repair by modulating the behavior of macrophages through Fe3O4 nanoparticles.

ACS APPLIED MATERIALS & INTERFACES (2021)

Review Engineering, Biomedical

From prevention to diagnosis and treatment: Biomedical applications of metal nanoparticle-hydrogel composites

Aaron J. Clasky et al.

Summary: Metal nanoparticle-hydrogel composites show great potential in biomedical applications, offering properties such as selectively responsive therapeutics, chemosensing, and enhanced substrates for tissue engineering. These hybrid materials represent a promising future direction in biomaterial development, with a wide range of capabilities for various biomedical needs.

ACTA BIOMATERIALIA (2021)

Review Chemistry, Applied

Chitosan-based nanoparticles against bacterial infections

Somaye Rashki et al.

Summary: Chitosan nanomaterials have gained attention in biomedicine for their high levels of biodegradability and biocompatibility, along with antimicrobial effects. Functional modification with other natural compounds, metallic antimicrobial particles, and antibiotics can enhance the efficiency of chitosan in wound dressing with antimicrobial activity. The antibacterial effect of chitosan is mainly associated with the leakage of intracellular content due to malfunction and altered permeability of the negatively charged cell membrane, on which chitosan is adsorbed. Additionally, chitosan nanoparticles possess favorable features of nanoparticles and their chitosan base, thereby exhibiting strengthened antibacterial potential. Polycations in chitosan nanoparticles target negatively charged bacterial membranes, resulting in a stronger effect on bacterial cells compared to pure chitosan.

CARBOHYDRATE POLYMERS (2021)

Review Biochemistry & Molecular Biology

Advances in Nanotechnology towards Development of Silver Nanoparticle-Based Wound-Healing Agents

Zimkhitha B. Nqakala et al.

Summary: Silver nanoparticles (AgNPs) have shown promise in wound healing due to their broad spectrum antimicrobial properties, low toxicity, efficacy at low concentrations, and lack of skin discoloration. They can be combined with other healing-promoting materials to provide optimal healing outcomes.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

Article Biology

Scratch-induced partial skin wounds re-epithelialize by sheets of independently migrating keratinocytes

Laura Bornes et al.

Summary: Research has shown that during re-epithelialization, keratinocytes adopt a strategy to bypass obstacles in order to quickly reestablish the protective skin barrier.

LIFE SCIENCE ALLIANCE (2021)

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Iron-Based Metal-Organic Frameworks in Drug Delivery and Biomedicine

Xianbin Liu et al.

Summary: Metal-organic frameworks (MOFs) are crystalline materials with structural rigidity and functional flexibility, offering large surface areas and high porosity, showing promise in chemistry, magnetism, and optics. In drug delivery, Fe-MOFs have shown high drug loading and excellent biocompatibility.

ACS APPLIED MATERIALS & INTERFACES (2021)

Review Chemistry, Multidisciplinary

Polymeric Tissue Adhesives

Sungmin Nam et al.

Summary: Polymeric tissue adhesives are versatile materials widely used in wound management, offering relative ease of use and rapid application while also acting as hemostats. Despite facing challenges, advancements in tissue adhesives may provide new possibilities for wound care.

CHEMICAL REVIEWS (2021)

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Smart wound dressings for wound healing

Ruonan Dong et al.

Summary: Wound management is a major challenge globally, and smart wound dressings offer potential solutions for promoting wound healing. By employing built-in sensors and smart materials, smart wound dressings can interact with wounds, sense and respond to changes in wound conditions or environment.

NANO TODAY (2021)

Review Biochemistry & Molecular Biology

Multifunctional hydrogels for wound healing: Special focus on biomacromolecular based hydrogels

Nahideh Asadi et al.

Summary: Hydrogels are widely used for wound healing applications due to their similarity to the native extracellular matrix and ability to provide a moist environment. However, lack of multifunctionality and low mechanical properties may limit their ability to support skin tissue regeneration. Incorporating various biomaterials and nanostructures is an emerging approach to develop multifunctional hydrogels for wound healing.

INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES (2021)

Review Materials Science, Biomaterials

Advances in non-covalent crosslinked polymer micelles for biomedical applications

Meihua Lin et al.

Summary: Crosslinked polymer micelles, as a drug delivery system, have advantages such as sensitivity to external stimuli, self-healing after damage, and no need for chemical crosslinking. Non-covalent crosslinked micelles can effectively deliver drugs to treatment sites, improve drug bioavailability, and reduce side effects.

MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS (2021)

Article Cell Biology

The Role of Oxidative Stress and Antioxidants in Diabetic Wound Healing

Liling Deng et al.

Summary: Foot ulcers in diabetic patients are often caused by various factors leading to slow wound healing, in which oxidative stress and antioxidants play important roles. By reducing oxidative stress levels, oxidative damage can be minimized to facilitate wound healing.

OXIDATIVE MEDICINE AND CELLULAR LONGEVITY (2021)

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Oxidative Stress and Tissue Repair: Mechanism, Biomarkers, and Therapeutics

Reggiani Vilela Goncalves et al.

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Multifunctional Hydrogel Nanocomposites for Biomedical Applications

Emma Barrett-Catton et al.

Summary: The incorporation of nanoparticles into hydrogels has been explored to enhance and add to the physical and biochemical properties of hydrogels, improving their potential for various applications.

POLYMERS (2021)

Review Chemistry, Physical

Biomedical Applications of Carbon Nanomaterials: Fullerenes, Quantum Dots, Nanotubes, Nanofibers, and Graphene

Manish Gaur et al.

Summary: Carbon nanomaterials (CNMs) have unique properties and a flexible structure, making them promising materials for drug delivery and bioimaging. Surface functionalization enhances their drug delivery efficiency and adaptability, leading to extensive applications in biomedical systems.

MATERIALS (2021)

Review Chemistry, Multidisciplinary

Antimicrobial Nano-Agents: The Copper Age

Maria Laura Ermini et al.

Summary: Copper-based nanoparticles have shown effective antimicrobial activity and potential contributions to infectious disease management, making them a promising therapeutic approach in the face of major health threats. Understanding the behaviors of CuNPs and their expected impact on disease treatment is crucial for further utilization of this technology.

ACS NANO (2021)

Article Chemistry, Multidisciplinary

Combined Antioxidant-Antibiotic Treatment for Effectively Healing Infected Diabetic Wounds Based on Polymer Vesicles

Tao Wang et al.

Summary: A combined antioxidant-antibiotic therapy was proposed using polymer vesicles loaded with ciprofloxacin and decorated with ceria nanoparticles, which showed high superoxide dismutase mimetic activity and enhanced antibacterial activity. In vivo treatment on a diabetic mice model demonstrated that the CIP-Ceria-PVs effectively healed infected diabetic wounds within 14 days.

ACS NANO (2021)

Review Biochemistry & Molecular Biology

Cellular Senescence and Inflammaging in the Skin Microenvironment

Young In Lee et al.

Summary: Cellular senescence and aging contribute to reduced ability to manage persistent inflammation, leading to inflammaging. This condition is associated with age-related chronic diseases and skin aging. Skin, being the largest organ and constantly exposed to external stressors, requires attention to the accumulation of senescent cells and changes in immune cells for cutaneous immunity during the aging process.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

Review Pharmacology & Pharmacy

Polymeric Nanomaterials for Efficient Delivery of Antimicrobial Agents

Yin Wang et al.

Summary: Bacterial infections have been a serious issue for thousands of years, and the emergence of multidrug resistance has made the treatment of these infections more urgent. Polymeric nanomaterials as carriers for antimicrobial agent delivery systems have shown advantages such as high targeting specificity and biocompatibility. Recent research highlights the potential of these systems in combating multidrug-resistant bacteria, anti-biofilms, promoting wound healing, tissue engineering, and cancer treatment.

PHARMACEUTICS (2021)

Article Chemistry, Medicinal

Silver Nanoparticle-Coated Ethyl Cellulose Inhibits Tumor Necrosis Factor-α of Breast Cancer Cells

Ahmed A. H. Abdellatif et al.

Summary: The study found that silver nanoparticles reduced with ethyl cellulose polymer (AgNPs-EC) have an inhibitory effect on TNF-alpha expression in breast cancer cells, with low cytotoxicity. This suggests the potential use of AgNPs-EC in the development of novel, safe approaches for cancer treatment in the future.

DRUG DESIGN DEVELOPMENT AND THERAPY (2021)

Article Multidisciplinary Sciences

Electron tunneling between vibrating atoms in a copper nano-filament

Mohammad Al-Mamun et al.

Summary: The study found that after remote heating, the resistance of fragile nanowires increases, but can spontaneously restore to the original value after cooling; while for robust low-resistance nanowires, remote heating does not affect resistance.

SCIENTIFIC REPORTS (2021)

Article Engineering, Biomedical

Zn-MOF Encapsulated Antibacterial and Degradable Microneedles Array for Promoting Wound Healing

Shun Yao et al.

Summary: A degradable zinc-MOF encapsulated microneedles array was fabricated in this study, showing excellent antibacterial activity and biocompatibility, which can accelerate wound healing and tissue regeneration.

ADVANCED HEALTHCARE MATERIALS (2021)

Review Engineering, Biomedical

Accelerated Skin Wound Healing by Electrical Stimulation

Ruizeng Luo et al.

Summary: When the integrity of the skin is compromised, an endogenous electric field is generated to facilitate wound healing, while exogenous electric fields can assist in treating wounds that cannot heal on their own. The effects of exogenous electrical stimulation on wound healing involve inflammation, blood flow, cell proliferation and migration, and wound scarring. New electrical stimulation methods and devices are characterized by being safe, low-cost, stable, and small in size.

ADVANCED HEALTHCARE MATERIALS (2021)

Editorial Material Dermatology

Human Wound and Its Burden: Updated 2020 Compendium of Estimates

Chandan K. Sen

Summary: Chronic wounds have a significant impact on the quality of life and healthcare economics in the United States, and the COVID-19 pandemic has disrupted wound care, particularly for patients with chronic wounds. There is a growing interest in understanding how social determinants of health affect wound care patient outcomes, and the pandemic underscores the importance of telemedicine in wound care.

ADVANCES IN WOUND CARE (2021)

Article Nanoscience & Nanotechnology

Construction of a Mesoporous Ceria Hollow Sphere/Enzyme Nanoreactor for Enhanced Cascade Catalytic Antibacterial Therapy

Jing Qin et al.

Summary: A nanoreactor with mesoporous structure and high specific surface area can efficiently convert glucose into highly toxic hydroxyl radicals, effectively killing bacteria and preventing biofilm formation without damage to normal tissues. This rational design of a nanoreactor shows potential applications in antibacterial therapy by enhancing catalytic activity.

ACS APPLIED MATERIALS & INTERFACES (2021)

Review Biochemistry & Molecular Biology

Polymer-Functionalized Upconversion Nanoparticles for Light/Imaging-Guided Drug Delivery

Lin Zhang et al.

Summary: The strong upconversion luminescence of upconversion nanoparticles allows for light-guided drug delivery. Surface polymer coatings provide stability, prevent protein corona formation, and serve as matrices for drug delivery, enhancing the functionality of UCNPs in medicine.

BIOMACROMOLECULES (2021)

Review Dermatology

Dermatological surgery: an update on suture materials and techniques. Part 2

E. Butt et al.

Summary: This article summarizes the latest evidence related to suture materials and wound closure techniques in dermatological surgery, highlighting the impact of suture choice on aspects such as scars, pain, and infection. Research on buried sutures still lacks adequate quality and further large-scale, multicentre, randomized trials are needed for comparison.

CLINICAL AND EXPERIMENTAL DERMATOLOGY (2021)

Review Dermatology

Dermatological surgery: an update on suture materials and techniques. Part 1

I. Ashraf et al.

Summary: There is significant variability in surgical suture materials and techniques used for dermatological surgery, but limited evidence specific to this area. Absorbable superficial sutures may be a preferable alternative, with subcuticular sutures and skin staples also potentially useful in certain situations. Further high-quality research, including multicentre randomized trials, is needed to better understand the optimal suture materials and techniques for dermatological surgery.

CLINICAL AND EXPERIMENTAL DERMATOLOGY (2021)

Review Biochemistry & Molecular Biology

Nanomaterials in Skin Regeneration and Rejuvenation

Emanuela Bellu et al.

Summary: The skin, as the external part of the human body, is easily affected by external stimuli; the emergence of nanomedicine provides a new approach for skin drug treatment; nanomaterials play a role in maintaining and replacing skin homeostasis, as well as wound healing, regeneration, and rejuvenation of skin tissue.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

Review Biochemistry & Molecular Biology

Silver Nanoparticles and Their Antibacterial Applications

Tamara Bruna et al.

Summary: Silver nanoparticles have excellent antimicrobial properties against a wide range of bacteria, including drug-resistant strains. Research on the synergistic effects of silver nanoparticles with other antibacterial agents for medical applications is ongoing to effectively treat or prevent infections.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

Review Chemistry, Multidisciplinary

Nanomaterials applied in wound healing: Mechanisms, limitations and perspectives

Menglei Wang et al.

Summary: Wounds on the skin can be caused by internal and external factors, creating challenges for clinicians in terms of infections, nonhealing chronic wounds, and aesthetic and functional recovery. The development of nanotechnology in biomedicine has introduced new materials and methods for wound treatment and holds great potential for intelligent healing.

JOURNAL OF CONTROLLED RELEASE (2021)

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Injectable nanofiber-polysaccharide self-healing hydrogels for wound healing

Hongyun Xuan et al.

Summary: A novel hydrogel based on carboxymethyl chitosan and aldehyde functionalized sodium alginate was developed with the addition of carboxymethyl-functionalized polymethyl methacrylate short nanofibers. The hydrogel demonstrated excellent injectability and self-healing abilities, as well as significantly promoting wound healing in rats according to in vivo experiments.

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Physical properties of gold nanoparticles affect skin penetration via hair follicles

Nethanel Friedman et al.

Summary: Drug penetration through the skin can be significantly influenced by particle size, with gold nanostars showing superiority over spherical particles in follicular penetration experiments. Understanding the optimal physical particle properties is crucial for improving drug delivery methods.

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Naturally-derived targeted therapy for wound healing: Beyond classical strategies

Saeed El-Ashram et al.

Summary: This passage summarizes the important factors affecting wound healing and the potential role of natural products in wound treatment. By studying these factors, it can help in the development of therapeutics that promote wound healing.

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Metal-Organic Frameworks (MOFs)-Based Nanomaterials for Drug Delivery

Mohammad Reza Saeb et al.

Summary: Metal-organic frameworks (MOFs), especially nanoscale MOFs (NMOFs), show exceptional tailorable properties and high potential for carrying anticancer drugs. Compared to other delivery systems, NMOFs are more flexible, have higher biodegradability potential, and can be easily functionalized.

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Biopolymer and Synthetic Polymer-Based Nanocomposites in Wound Dressing Applications: A Review

Ravichandran Gobi et al.

Summary: Biopolymers and synthetic polymer-based nanocomposites have promising applications in the biomedical field for wound dressings, tissue repair, and drug delivery. By blending them with nanoparticles, the properties of materials are modified to achieve better application outcomes.

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Nanomaterials of Natural Bioactive Compounds for Wound Healing: Novel Drug Delivery Approach

Vinay Kant et al.

Summary: Wound healing is a complex biological process involving sequential biochemical reactions to restore cellular integrity. The market for wound-care products is vast, with natural bioactive agents showing potential for promoting wound healing. Encapsulating these agents into nano-formulations has helped overcome limitations and improve their applicability in clinical practices.

CURRENT DRUG DELIVERY (2021)

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The Antimicrobial and Anti-Inflammatory Effects of Silver Nanoparticles Synthesised from Cotyledon orbiculata Aqueous Extract

Caroline Tyavambiza et al.

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Cellular human tissue-engineered skin substitutes investigated for deep and difficult to heal injuries

Alvaro Sierra-Sanchez et al.

Summary: TESSs, including autologous and allogeneic substitutes, hold promise for treating significant skin injuries and dermatological pathologies. Future directions in the field involve improving animal models, incorporating diverse cell types, and developing 3D bioprinting techniques.

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Living in Your Skin: Microbes, Molecules, and Mechanisms

Mary Hannah Swaney et al.

Summary: The human skin functions as a barrier against the external environment and provides protection for the skin microbiome, which includes resident microbiota. The cooperation between the microbiome, host skin cells, and the immune system is crucial for maintaining skin health. Disruption of this balance, such as pathogen invasion, can impair skin function.

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A Review of the Contribution of Mast Cells in Wound Healing: Involved Molecular and Cellular Mechanisms

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Guidelines on the classification of diabetic foot ulcers (IWGDF 2019)

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Metal-Based Nanoparticles as Antimicrobial Agents: An Overview

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Recent Advances in Nanomaterial-Based Wound-Healing Therapeutics

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Biosynthesis, Characterization, and Wound-Healing Activity of Phenytoin-Loaded Copper Nanoparticles

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Antioxidative photochemoprotector effects of cerium oxide nanoparticles on UVB irradiated fibroblast cells

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Biodegradable Nanopolymers in Cardiac Tissue Engineering: From Concept Towards Nanomedicine

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Silver nanoparticles: Advanced and promising technology in diabetic wound therapy

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Nanomaterials for Wound Dressings: An Up-to-Date Overview

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Ceria Nanoparticles Decrease UVA-Induced Fibroblast Death Through Cell Redox Regulation Leading to Cell Survival, Migration and Proliferation

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The Cutaneous Wound Innate Immunological Microenvironment

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Nanostructures based on vanadium disulfide growing on UCNPs: simple synthesis, dual-mode imaging, and photothermal therapy

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Multiple cargo deliveries of growth factors and antimicrobial peptide using biodegradable nanopolymer as a potential wound healing system

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Copper nanoparticles promote rapid wound healing in acute full thickness defect via acceleration of skin cell migration, proliferation, and neovascularization

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