4.7 Review

The Role of Dexmedetomidine in Tumor-Progressive Factors in the Perioperative Period and Cancer Recurrence: A Narrative Review

相关参考文献

注意:仅列出部分参考文献,下载原文获取全部文献信息。
Article Pharmacology & Pharmacy

The role of the vagus nerve on dexmedetomidine promoting survival and lung protection in a sepsis model in rats

Yumo Li et al.

Summary: This study found that Dexmedetomidine plays a role in protecting the lungs by increasing vagal nerve tone. The indirect anti-inflammatory effects and direct cytoprotective effects of Dexmedetomidine are likely achieved through increased vagal nerve tone and activation of alpha 2-adrenoceptors, respectively.

EUROPEAN JOURNAL OF PHARMACOLOGY (2022)

Review Oncology

Effects of Anesthesia and Anesthetic Techniques on Metastasis of Lung Cancers: A Narrative Review

Zhenghuan Song et al.

Summary: Anesthesia and anesthetic techniques may play an important role in tumor progression and lung metastasis, understanding of which can help design more effective tumor management strategies.

CANCER MANAGEMENT AND RESEARCH (2022)

Article Oncology

Effects of dexmedetomidine on immune response in patients undergoing radical and reconstructive surgery for oral cancer

Lili Huang et al.

Summary: Dexmedetomidine can mitigate immunosuppression in patients undergoing radical and reconstructive surgery for oral cancer, with positive effects on T lymphocyte subsets, B lymphocytes, dendritic cells, and myeloid-derived suppressor cells among other immunological indicators.

ONCOLOGY LETTERS (2021)

Article Oncology

Immunomodulatory Effects of Perioperative Dexmedetomidine in Ovarian Cancer: An In Vitro and Xenograft Mouse Model Study

Seokyung Shin et al.

Summary: Dexmedetomidine does not affect cell viability or cell cycle, but can promote the recovery of NK cell activity, reduce cortisol and TNF-alpha levels, leading to a decrease in tumor burden after surgery. Further studies are needed to understand the mechanisms by which dexmedetomidine acts on cancer and immune cells.

FRONTIERS IN ONCOLOGY (2021)

Article Anesthesiology

Perioperative dexmedetomidine and 5-year survival in patients undergoing cardiac surgery

Ke Peng et al.

Summary: The study demonstrated a positive association between perioperative dexmedetomidine use and 5-year survival after cardiac surgery, with patients receiving dexmedetomidine having higher survival rates during the postoperative period.

BRITISH JOURNAL OF ANAESTHESIA (2021)

Review Immunology

The immunomodulatory mechanism of dexmedetomidine

Koichi Yuki

Summary: Dexmedetomidine is increasingly being used in perioperative care for surgical patients and has immunomodulatory effects, potentially improving outcomes in organ injury, cancer surgery, and infection. Further research is needed to fully understand its clinical application and impact on immune functions.

INTERNATIONAL IMMUNOPHARMACOLOGY (2021)

Article Oncology

Effect of Dexmedetomidine on Perioperative Stress Response and Immune Function in Patients With Tumors

Lihong Zheng et al.

TECHNOLOGY IN CANCER RESEARCH & TREATMENT (2020)

Article Anesthesiology

Dexmedetomidine metabolic clearance is not affected by fat mass in obese patients

A. Rolle et al.

BRITISH JOURNAL OF ANAESTHESIA (2018)

Article Anesthesiology

Dexmedetomidine promotes metastasis in rodent models of breast, lung, and colon cancers

H. Lavon et al.

BRITISH JOURNAL OF ANAESTHESIA (2018)

Review Oncology

Stress, inflammation, and eicosanoids: an emerging perspective

Sujanitha Umamaheswaran et al.

CANCER AND METASTASIS REVIEWS (2018)

Review Medicine, Research & Experimental

Effects of surgery and anesthetic choice on immunosuppression and cancer recurrence

Ryungsa Kim

JOURNAL OF TRANSLATIONAL MEDICINE (2018)

Review Public, Environmental & Occupational Health

Inflammation and cancer

Mariko Murata

ENVIRONMENTAL HEALTH AND PREVENTIVE MEDICINE (2018)

Article Oncology

Implicating anaesthesia and the perioperative period in cancer recurrence and metastasis

Julia A. Dubowitz et al.

CLINICAL & EXPERIMENTAL METASTASIS (2018)

Review Pharmacology & Pharmacy

Clinical Pharmacokinetics and Pharmacodynamics of Dexmedetomidine

Maud A. S. Weerink et al.

CLINICAL PHARMACOKINETICS (2017)

Article Cell Biology

Alpha2-adrenoceptor agonists trigger prolactin signaling in breast cancer cells

Lilian Fedra Castillo et al.

CELLULAR SIGNALLING (2017)

Article Anatomy & Morphology

Prolactin Receptor Expression is an Independent Favorable Prognostic Marker in Human Breast Cancer

Ibrahim Y. Hachim et al.

APPLIED IMMUNOHISTOCHEMISTRY & MOLECULAR MORPHOLOGY (2016)

Review Pharmacology & Pharmacy

The prolactin receptor as a therapeutic target in human diseases: browsing new potential indications

Vincent Goffin et al.

EXPERT OPINION ON THERAPEUTIC TARGETS (2015)

Article Surgery

Effects of dexmedetomidine on patients undergoing radical gastrectomy

Yulan Wang et al.

JOURNAL OF SURGICAL RESEARCH (2015)

Review Pharmacology & Pharmacy

Adrenergic regulation of innate immunity: a review

Angela Scanzano et al.

FRONTIERS IN PHARMACOLOGY (2015)

Article Cardiac & Cardiovascular Systems

Significant increase in circulating tumour cells in pulmonary venous blood during surgical manipulation in patients with primary lung cancer

Masaki Hashimoto et al.

INTERACTIVE CARDIOVASCULAR AND THORACIC SURGERY (2014)

Article Cardiac & Cardiovascular Systems

Perioperative Dexmedetomidine Improves Outcomes of Cardiac Surgery

Fuhai Ji et al.

CIRCULATION (2013)

Review Oncology

Cancer recurrence after surgery: Direct and indirect effects of anesthetic agents*

Aniket N. Tavare et al.

INTERNATIONAL JOURNAL OF CANCER (2012)

Article Pathology

Aligned Collagen Is a Prognostic Signature for Survival in Human Breast Carcinoma

Matthew W. Conklin et al.

AMERICAN JOURNAL OF PATHOLOGY (2011)

Review Biochemistry & Molecular Biology

Immunity, Inflammation, and Cancer

Sergei I. Grivennikov et al.

Article Pharmacology & Pharmacy

α2-Adrenoceptor action on cell proliferation and mammary tumour growth in mice

A. Bruzzone et al.

BRITISH JOURNAL OF PHARMACOLOGY (2008)

Review Biochemistry & Molecular Biology

Catecholamines-Crafty weapons in the inflammatory arsenal of Immune/Inflammatory cells or opening pandora's box?

Michael A. Flierl et al.

MOLECULAR MEDICINE (2008)

Review Multidisciplinary Sciences

Origin and physiological roles of inflammation

Ruslan Medzhitov

NATURE (2008)

Review Immunology

Evolving functions of endothelial cells in inflammation

Jordan S. Pober et al.

NATURE REVIEWS IMMUNOLOGY (2007)

Article Immunology

Autonomic innervation and regulation of the immune system (1987-2007)

Dwight M. Nance et al.

BRAIN BEHAVIOR AND IMMUNITY (2007)

Article Oncology

Probing the microenvironment of mammary tumors using multiphoton microscopy

Mazen Sidani et al.

JOURNAL OF MAMMARY GLAND BIOLOGY AND NEOPLASIA (2006)

Review Immunology

Lymphoid organ development: from ontogeny to neogenesis

DL Drayton et al.

NATURE IMMUNOLOGY (2006)

Article Anesthesiology

Dexmedetomidine decreases perioperative myocardial lactate release in dogs

HM Willigers et al.

ANESTHESIA AND ANALGESIA (2003)

Article Biophysics

Coherent scattering in multi-harmonic light microscopy

L Moreaux et al.

BIOPHYSICAL JOURNAL (2001)

Article Endocrinology & Metabolism

Effect of clonidine on plasma ACTH, cortisol and melatonin in children

A Muñóz-Hoyos et al.

JOURNAL OF PINEAL RESEARCH (2000)

Article Surgery

Manipulation of the metabolic response in clinical practice

H Kehlet

WORLD JOURNAL OF SURGERY (2000)

Article Anesthesiology

Sedative, amnestic, and analgesic properties of small-dose dexmedetomidine infusions

JE Hall et al.

ANESTHESIA AND ANALGESIA (2000)