Electrochemical oxidation behavior of itraconazole at different electrodes and its anodic stripping determination in pharmaceuticals and biological fluids

The oxidation of itraconazole at three different electrodes; ultra-trace graphite (UTGE), pencil graphite (PGE) and carbon paste (CPE) electrodes were studied voltammetrically. After the optimization of solution pH, accumulation potential and accumulation time, anodic stripping differential pulse and anodic stripping square wave voltammetric peaks were obtained. The oxidation mechanism was proposed. Based on these findings, a simple and not time-consuming procedure was successfully applied for the determination of itraconazole in pharmaceutics and biological fluids. (C) 2015 Elsevier B.V. All rights reserved.