期刊
JOURNAL OF ELECTROANALYTICAL CHEMISTRY
卷 763, 期 -, 页码 51-62出版社
ELSEVIER SCIENCE SA
DOI: 10.1016/j.jelechem.2015.12.047
关键词
Itraconazole; Anodic stripping; Biological fluids; Capsules; Electrode
资金
- National Organization of Drug Control and Research of Egypt
The oxidation of itraconazole at three different electrodes; ultra-trace graphite (UTGE), pencil graphite (PGE) and carbon paste (CPE) electrodes were studied voltammetrically. After the optimization of solution pH, accumulation potential and accumulation time, anodic stripping differential pulse and anodic stripping square wave voltammetric peaks were obtained. The oxidation mechanism was proposed. Based on these findings, a simple and not time-consuming procedure was successfully applied for the determination of itraconazole in pharmaceutics and biological fluids. (C) 2015 Elsevier B.V. All rights reserved.
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