Review on recent development of quinoline for anticancer activities

Quinoline is an efficient scaffold for anticancer drug development as its derivatives have shown potent results through several mechanisms like growth regulators through apoptosis, dis-ruption of cell migration, inhibition of angiogenesis, modulation of nuclear receptor responsiveness and cell cycle arrest, etc., The potential of quinoline derivatives has been proved in several cancer cell lines like breast cancer, colon cancer, lung cancer, colorectal cancer, renal cancer, etc. This review article aims to provide information about the synthesis, potential of the anticancer property, cytotoxicity, and level of clinical treatments, which could lay out the research to develop more effec-tive quinoline-derived anticancer drugs.(c) 2022 Published by Elsevier B.V. on behalf of King Saud University. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

Automated summary

This article summarizes the effectiveness of quinoline and its derivatives as efficient scaffolds for anticancer drug development, demonstrating their potent anticancer potential through mechanisms such as apoptosis, disruption of cell migration, inhibition of angiogenesis, modulation of nuclear receptor responsiveness, and cell cycle arrest.