期刊
ACS CATALYSIS
卷 12, 期 14, 页码 8667-8675出版社
AMER CHEMICAL SOC
DOI: 10.1021/acscatal.2c01526
关键词
palladium-catalyzed; amino acid-catalyzed; enantioselectivity; regioselectivity; hydroarylation
资金
- Tianjin University
- State Key Laboratory of Elemento-Organic Chemistry
- National Natural Science Foundation of China [21801181, 22073066, 21503143, 21975179]
A practical palladium and amino acid co-catalyzed hydroarylation of unbiased alkenes has been developed, which can construct isolated chiral Csp(2)-Csp(3) bonds with good regio- and enantioselectivity. The potential synthetic utility of a representative product was wellillustrated by further transformations. Furthermore, the mechanism of this reaction was intensively studied through control experiments and DFT calculations.
A practical palladium and amino acid co-catalyzed hydroarylation of unbiased alkenes has been developed. Using the transient-directing strategy, this chemistry could construct isolated chiral Csp(2)-Csp(3) bonds with good regio- and enantioselectivity. The potential synthetic utility of a representative product was wellillustrated by further transformations. Furthermore, the mechanism of this reaction was intensively studied through control experiments and DFT calculations.
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