期刊
ACS CATALYSIS
卷 12, 期 16, 页码 10294-10303出版社
AMER CHEMICAL SOC
DOI: 10.1021/acscatal.2c02573
关键词
heterogeneous iridium catalysis; julolidines; reductive annulation; quinolines and conjugated enones; functional N-heterocycles
资金
- National Natural Science Foundation of China [21971071]
- Natural Science Foundation of Guangdong Province [2021A1515010155]
In this study, we developed a hierarchically porous ZrO2-supported iridium catalyst derived from MOF, which exhibits sufficient accessible catalytic sites. This catalyst was successfully used for the selective and direct construction of julolidines via catalytic reductive annulation. It shows good substrate and functional group compatibility, can be reused, has high step and atom efficiency, and is easy to apply for the fabrication of functional molecules.
Here, we describe the development of a MOF-derived hierarchically porous ZrO2-supported iridium catalyst (Ir-N@HP-mesoZrO2), featuring sufficient accessible catalytic sites even with ultralow iridium loading. Such a catalyst was successfully applied to selective and direct construction of julolidines via catalytic reductive annulation of readily available quinolines and conjugated enones, proceeding with good substrate and functional group compatibility, reusable catalyst, high step and atom efficiency, and easy applicability for the fabrication of functional molecules. The present work opens a door to further develop useful transformations by merging hydrogen transfer-mediated substrate activation with in situ incorporation of a coupling sequence under heterogeneous reductive catalysis.
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