4.8 Article

Early treatment regimens achieve sustained virologic remission in infant macaques infected with SIV at birth

相关参考文献

注意:仅列出部分参考文献,下载原文获取全部文献信息。
Article Biochemistry & Molecular Biology

Parallel analysis of transcription, integration, and sequence of single HIV-1 proviruses

Kevin B. Einkauf et al.

Summary: By studying the evolution of transcriptionally active and silent proviral genomes and epigenomes in individuals receiving antiretroviral therapy, we have found that transcriptionally active HIV-1 proviruses are dynamically evolving under host factors' selection pressure.
Article Multidisciplinary Sciences

Longitudinal clonal dynamics of HIV-1 latent reservoirs measured by combination quadruplex polymerase chain reaction and sequencing

Alice Cho et al.

Summary: HIV-1 infection leads to the formation of a long-lasting reservoir of latently infected CD4(+) T cells, consisting of intact and defective proviruses. This study used Q4PCR to quantify the reservoir content and found that the defective reservoir remained stable while the intact proviral reservoir decayed over time. Both the intact and defective proviral reservoirs showed dynamic changes, with an enrichment of intact proviruses in expanded CD4(+) T cell clones and a decrease in overall reservoir complexity.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2022)

Article Multidisciplinary Sciences

HIV-1 diversity considerations in the application of the Intact Proviral DNA Assay (IPDA)

Natalie N. Kinloch et al.

Summary: The Intact Proviral DNA Assay quantifies intact HIV reservoirs but faces a 28% failure rate due to HIV-1 polymorphism. Within-host HIV-1 diversity poses a challenge to the accuracy of IPDA measurements.

NATURE COMMUNICATIONS (2021)

Article Cell Biology

Signatures of immune selection in intact and defective proviruses distinguish HIV-1 elite controllers

Xiaodong Lian et al.

Summary: The study found that defective proviruses in elite controllers are more commonly located in permissive genic euchromatin positions, while intact proviruses are frequently found in heterochromatin regions, indicating differential immune selection pressure on intact and defective proviruses in ECs. The intact and defective proviruses from ECs also showed reduced frequencies of escape mutations in key immune response regions, possibly due to the small and poorly inducible reservoir in ECs. Additionally, a subset of ECs harbored nef deletions in intact proviruses, which may increase viral vulnerability to host immunity in these individuals.

SCIENCE TRANSLATIONAL MEDICINE (2021)

Review Virology

Residual Proviral Reservoirs: A High Risk for HIV Persistence and Driving Forces for Viral Rebound after Analytical Treatment Interruption

Xiaolei Wang et al.

Summary: Although antiretroviral therapy (ART) has significantly suppressed human immunodeficiency virus (HIV) replication and rendered the virus undetectable, a small number of residual replicable HIV proviruses can still persist, leading to viral rebound after treatment interruption. With current treatments unable to eradicate HIV proviral reservoirs, developing new therapeutic strategies to eliminate these reservoirs is crucial for achieving ART-free HIV remission.

VIRUSES-BASEL (2021)

Article Infectious Diseases

Early ART-initiation and longer ART duration reduces HIV-1 proviral DNA levels in children from the CHER trial

Helen Payne et al.

Summary: This study found that longer duration of antiretroviral therapy (ART) is associated with lower levels of HIV-1 proviral DNA. Additionally, higher total CD8 count at ART initiation was also linked to lower HIV-1 proviral DNA. However, HIV-1 proviral DNA levels were higher in individuals with positive HIV-1 serology.

AIDS RESEARCH AND THERAPY (2021)

Article Infectious Diseases

The CARMA Study: Early Infant Antiretroviral Therapy-Timing Impacts on Total HIV-1 DNA Quantitation 12 Years Later

Caroline Foster et al.

Summary: This study investigated factors associated with lower levels of total HIV-1 DNA in perinatal HIV infection, finding that younger age and lower VL at ART initiation were linked to reduced reservoir size.

JOURNAL OF THE PEDIATRIC INFECTIOUS DISEASES SOCIETY (2021)

Article Cell Biology

Different human resting memory CD4+ T cell subsets show similar low inducibility of latent HIV-1 proviruses

Kyungyoon J. Kwon et al.

SCIENCE TRANSLATIONAL MEDICINE (2020)

Review Microbiology

The Biology of the HIV-1 Latent Reservoir and Implications for Cure Strategies

Lillian B. Cohn et al.

CELL HOST & MICROBE (2020)

Article Medicine, Research & Experimental

Induction of Transient Virus Replication Facilitates Antigen-Independent Isolation of SIV-Specific Monoclonal Antibodies

Nuria Pedreno-Lopez et al.

MOLECULAR THERAPY-METHODS & CLINICAL DEVELOPMENT (2020)

Article Infectious Diseases

Dolutegravir and neural tube defects: a new insight

Laurent Chouchana et al.

LANCET INFECTIOUS DISEASES (2020)

Article Multidisciplinary Sciences

Intact proviral DNA assay analysis of large cohorts of people with HIV provides a benchmark for the frequency and composition of persistent proviral DNA

Francesco R. Simonetti et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2020)

Article Multidisciplinary Sciences

Distinct viral reservoirs in individuals with spontaneous control of HIV-1

Chenyang Jiang et al.

NATURE (2020)

Article Medicine, General & Internal

Early antiretroviral treatment of infants to attain HIV remission

Louise Kuhn et al.

ECLINICALMEDICINE (2020)

Article Medicine, Research & Experimental

Intact HIV-1 proviruses accumulate at distinct chromosomal positions during prolonged antiretroviral therapy

Kevin B. Einkauf et al.

JOURNAL OF CLINICAL INVESTIGATION (2019)

Article Multidisciplinary Sciences

Defining early SIV replication and dissemination dynamics following vaginal transmission

Claire Deleage et al.

SCIENCE ADVANCES (2019)

Article Microbiology

The Landscape of Persistent Viral Genomes in ART-Treated SIV, SHIV, and HIV-2 Infections

Alexandra M. Bender et al.

CELL HOST & MICROBE (2019)

Article Medicine, General & Internal

Neural-Tube Defects and Antiretroviral Treatment Regimens in Botswana

Rebecca Zash et al.

NEW ENGLAND JOURNAL OF MEDICINE (2019)

Article Multidisciplinary Sciences

Determinants of HIV-1 reservoir size and long-term dynamics during suppressive ART

Nadine Bachmann et al.

NATURE COMMUNICATIONS (2019)

News Item Infectious Diseases

Dolutegravir becomes first choice for HIV

Susan Rahimi

LANCET INFECTIOUS DISEASES (2019)

Article Cell Biology

The replication-competent HIV-1 latent reservoir is primarily established near the time of therapy initiation

Melissa-Rose Abrahams et al.

SCIENCE TRANSLATIONAL MEDICINE (2019)

Review Virology

Digital PCR as a tool to measure HIV persistence

Sofie Rutsaert et al.

RETROVIROLOGY (2018)

Letter Medicine, General & Internal

Neural-Tube Defects with Dolutegravir Treatment from the Time of Conception

Rebecca Zash et al.

NEW ENGLAND JOURNAL OF MEDICINE (2018)

Article Multidisciplinary Sciences

Antibody and TLR7 agonist delay viral rebound in SHIV-infected monkeys

Erica N. Borducchi et al.

NATURE (2018)

Article Multidisciplinary Sciences

Prevention of SIVmac251 reservoir seeding in rhesus monkeys by early antiretroviral therapy

James B. Whitney et al.

NATURE COMMUNICATIONS (2018)

Article Multidisciplinary Sciences

Single-cell analysis of HIV-1 transcriptional activity reveals expression of proviruses in expanded clones during ART

Ann Wiegand et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2017)

Review Infectious Diseases

Distribution and fate of HIV-1 unintegrated DNA species: a comprehensive update

Faysal Bin Hamid et al.

AIDS RESEARCH AND THERAPY (2017)

Review Medicine, Research & Experimental

Early Combination Antiretroviral Therapy Limits HIV-1 Persistence in Children

Katherine Luzuriaga

ANNUAL REVIEW OF MEDICINE, VOL 67 (2016)

Review Microbiology

Total HIV-1 DNA, a Marker of Viral Reservoir Dynamics with Clinical Implications

Veronique Avettand-Fenoel et al.

CLINICAL MICROBIOLOGY REVIEWS (2016)

Review Virology

HIV-1 latent reservoir: size matters

Flavia Hodel et al.

FUTURE VIROLOGY (2016)

Article Microbiology

Novel Assays for Measurement of Total Cell-Associated HIV-1 DNA and RNA

Feiyu Hong et al.

JOURNAL OF CLINICAL MICROBIOLOGY (2016)

Article Biochemistry & Molecular Biology

Defective proviruses rapidly accumulate during acute HIV-1 infection

Katherine M. Bruner et al.

NATURE MEDICINE (2016)

Article Multidisciplinary Sciences

Defective HIV-1 proviruses produce novel protein-coding RNA species in HIV-infected patients on combination antiretroviral therapy

Hiromi Imamichi et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2016)

Article Medicine, General & Internal

HIV DNA Set Point is Rapidly Established in Acute HIV Infection and Dramatically Reduced by Early ART

Jintanat Ananworanich et al.

EBIOMEDICINE (2016)

Review Immunology

Paediatric HIV infection: the potential for cure

Philip J. Goulder et al.

NATURE REVIEWS IMMUNOLOGY (2016)

Letter Medicine, General & Internal

Viremic Relapse after HIV-1 Remission in a Perinatally Infected Child

Katherine Luzuriaga et al.

NEW ENGLAND JOURNAL OF MEDICINE (2015)

Review Immunology

Very early combination antiretroviral therapy in infants: prospects for cure

Kaitlin Rainwater-Lovett et al.

CURRENT OPINION IN HIV AND AIDS (2015)

Editorial Material Medicine, General & Internal

No cure of HIV infection in a child despite early treatment and apparent viral clearance

Vania Giacomet et al.

LANCET (2014)

Article Multidisciplinary Sciences

Rapid seeding of the viral reservoir prior to SIV viraemia in rhesus monkeys

James B. Whitney et al.

NATURE (2014)

Article Biochemistry & Molecular Biology

Early development of broadly neutralizing antibodies in HIV-1-infected infants

Leslie Goo et al.

NATURE MEDICINE (2014)

Review Immunology

Immediate antiretroviral therapy in young HIV-infected children: benefits and risks

Intira J. Collins et al.

CURRENT OPINION IN HIV AND AIDS (2014)

Review Immunology

Immunity to HIV in early life

Maximilian Muenchhoff et al.

FRONTIERS IN IMMUNOLOGY (2014)

Article Hematology

Interleukin-7 promotes HIV persistence during antiretroviral therapy

Claire Vandergeeten et al.

Article Medicine, General & Internal

Absence of Detectable HIV-1 Viremia after Treatment Cessation in an Infant

Deborah Persaud et al.

NEW ENGLAND JOURNAL OF MEDICINE (2013)

Article Medicine, Research & Experimental

HIV DNA Integration

Robert Craigie et al.

COLD SPRING HARBOR PERSPECTIVES IN MEDICINE (2012)

Review Virology

The role of unintegrated DNA in HIV infection

Richard D. Sloan et al.

RETROVIROLOGY (2011)

Article Multidisciplinary Sciences

High frequencies of resting CD4+ T cells containing integrated viral DNA are found in rhesus macaques during acute lentivirus infections

Yoshiaki Nishimura et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2009)

Article Immunology

Dynamics of total, linear nonintegrated, and integrated HIV-1 DNA in vivo and in vitro

Kersten K. Koelsch et al.

JOURNAL OF INFECTIOUS DISEASES (2008)

Article Medicine, General & Internal

Early Antiretroviral Therapy and Mortality among HIV-Infected Infants.

Avy Violari et al.

NEW ENGLAND JOURNAL OF MEDICINE (2008)