期刊
INTERNATIONAL JOURNAL OF ORAL SCIENCE
卷 14, 期 1, 页码 -出版社
SPRINGERNATURE
DOI: 10.1038/s41368-022-00187-z
关键词
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资金
- National Natural Science Foundation of China [81974347]
- Science and Technology Program of Sichuan Province [2021YJ0444]
- China Postdoctoral Science Foundation [2021M702351]
- West China Hospital, Sichuan University [2020HXBH081]
Osteoarthritis is a prevalent joint disease with no effective treatment currently available. Recent studies have discovered that exosomes, a type of cell-to-cell communication, can regulate cartilage behavior by delivering bioactive molecules, making them promising candidates for monitoring and treating osteoarthritis.
Osteoarthritis (OA) is a prevalent degenerative joint disease characterized by cartilage loss and accounts for a major source of pain and disability worldwide. However, effective strategies for cartilage repair are lacking, and patients with advanced OA usually need joint replacement. Better comprehending OA pathogenesis may lead to transformative therapeutics. Recently studies have reported that exosomes act as a new means of cell-to-cell communication by delivering multiple bioactive molecules to create a particular microenvironment that tunes cartilage behavior. Specifically, exosome cargos, such as noncoding RNAs (ncRNAs) and proteins, play a crucial role in OA progression by regulating the proliferation, apoptosis, autophagy, and inflammatory response of joint cells, rendering them promising candidates for OA monitoring and treatment. This review systematically summarizes the current insight regarding the biogenesis and function of exosomes and their potential as therapeutic tools targeting cell-to-cell communication in OA, suggesting new realms to improve OA management.
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