4.6 Article

Targeted inhibition of osteoclastogenesis reveals the pathogenesis and therapeutics of bone loss under sympathetic neurostress

相关参考文献

注意:仅列出部分参考文献,下载原文获取全部文献信息。
Article Chemistry, Physical

Sympathetic Neurostress Drives Osteoblastic Exosomal MiR-21 Transfer to Disrupt Bone Homeostasis and Promote Osteopenia

Cheng-Hu Hu et al.

Summary: Sympathetic neurostimulation through beta(1/2)-adrenergic receptor signaling triggers the transcription of miR-21 in osteoblasts, which is then transferred to osteoclast progenitors via exosomes to dictate osteoclastogenesis. Pharmacological inhibition of exosome release can suppress this miR-21 transfer and ameliorate bone loss under stress-induced depression conditions.

SMALL METHODS (2022)

Article Biochemistry & Molecular Biology

Photoreceptor protection by mesenchymal stem cell transplantation identifies exosomal MiR-21 as a therapeutic for retinal degeneration

Chun-Lei Deng et al.

Summary: The study revealed the therapeutic effects and mechanisms of mesenchymal stem cell transplantation and exosomal transplantation on photoreceptor injuries, with a focus on miR-21 mediation for photoreceptor viability. These methods demonstrated long-lasting efficacy in treating retinal degenerative diseases, highlighting their potential as a therapeutic approach.

CELL DEATH AND DIFFERENTIATION (2021)

Article Biochemistry & Molecular Biology

Osteoclasts recycle via osteomorphs during RANKL-stimulated bone resorption

Michelle M. McDonald et al.

Summary: Research has shown that RANKL-stimulated osteoclasts can undergo fission to form osteomorphs, which are involved in the regulation of bone resorption and could be targeted for the treatment of skeletal diseases. Single-cell RNA sequencing revealed that osteomorphs are transcriptionally distinct from osteoclasts and macrophages, expressing non-canonical osteoclast genes associated with bone phenotypes when deleted in mice.
Review Chemistry, Multidisciplinary

Crosstalk between Bone and Nerves within Bone

Qian-Qian Wan et al.

Summary: This review comprehensively analyzes the possible crosstalk between bone and intrabony peripheral nerves, highlighting the role of peripheral nerves in bone development and repair through signals such as neurotransmitters, neuropeptides, and neurotrophins. In return, bone supports nerves mechanically and offers a protective environment. This crosstalk is not limited to physiological conditions, but also plays a role in various bone diseases, providing potential avenues for tissue engineering and disease treatment.

ADVANCED SCIENCE (2021)

Article Multidisciplinary Sciences

Damaged brain accelerates bone healing by releasing small extracellular vesicles that target osteoprogenitors

Wei Xia et al.

Summary: Concomitant traumatic brain injury can accelerate bone healing, but the specific mechanism is currently unclear. The study shows that injured neurons release small extracellular vesicles enriched with osteogenic miRNA, which target osteoprogenitors to stimulate bone formation.

NATURE COMMUNICATIONS (2021)

Article Immunology

Adrenergic regulation of the vasculature impairs leukocyte interstitial migration and suppresses immune responses

Sapna Devi et al.

Summary: The study demonstrates that adrenergic receptors play a crucial role in modulating leukocyte mobility and immune responses, shedding light on the link between sympathetic nervous system activation and compromised immunity.

IMMUNITY (2021)

Article Multidisciplinary Sciences

Corticosterone inhibits GAS6 to govern hair follicle stem-cell quiescence

Sekyu Choi et al.

Summary: The study revealed that corticosterone regulates hair follicle stem cell (HFSC) quiescence and hair growth in mice, with chronic stress prolonging HFSC quiescence and maintaining hair follicles in an extended resting phase. The mechanism involves corticosterone suppressing the expression of Gas6 gene through acting on dermal papillae, and restoring Gas6 expression can overcome stress-induced inhibition of HFSC activation and hair growth.

NATURE (2021)

Article Multidisciplinary Sciences

Targeted apoptosis of macrophages and osteoclasts in arthritic joints is effective against advanced inflammatory arthritis

Caifeng Deng et al.

Summary: The study successfully delivered celastrol using enzyme-responsive nanoparticles to induce apoptosis of OCs and macrophages in rheumatoid arthritis joints, reducing inflammation and showing therapeutic effects in a rat model.

NATURE COMMUNICATIONS (2021)

Article Cell Biology

Chronic stress physically spares but functionally impairs innate-like invariant T cells

Patrick T. Rudak et al.

Summary: Long-term psychological stress inhibits T helper 1 (T(H)1) and T(H)2-type responses by invariant natural killer T (iNKT) cells, without causing cell death. Stress triggers a split inflammatory signature in activated iNKT cells, mediated by glucocorticoid receptor signaling, and impairs their ability to enhance cytotoxicity against lymphoma or reduce metastatic melanoma burden. Stress also affects mucosa-associated invariant T (MAIT) cells' responses, but can be corrected with habituation to predictable stressors.

CELL REPORTS (2021)

Review Nanoscience & Nanotechnology

The current landscape of nucleic acid therapeutics

Jayesh A. Kulkarni et al.

Summary: The increasing number of approved nucleic acid therapeutics demonstrates their potential for long-lasting or curative effects by targeting genetic blueprints; however, their clinical translation relies on advances in delivery technologies. Four platform technologies, including antisense oligonucleotides, small interfering RNA conjugates, lipid nanoparticles, and adeno-associated virus vectors, have enabled the clinical translation of nucleic acid therapeutics, leading to the approval of cutting-edge genetic drugs.

NATURE NANOTECHNOLOGY (2021)

Review Biochemistry & Molecular Biology

Mitochondrial Regulation of Stem Cells in Bone Homeostasis

Chen-Xi Zheng et al.

TRENDS IN MOLECULAR MEDICINE (2020)

Review Cell Biology

Epigenetic Regulation of Mesenchymal Stem Cell Homeostasis

Bing-Dong Sui et al.

TRENDS IN CELL BIOLOGY (2020)

Review Medicine, Research & Experimental

Improved Nucleic Acid Therapy with Advanced Nanoscale Biotechnology

Yuhua Weng et al.

MOLECULAR THERAPY-NUCLEIC ACIDS (2020)

Article Dentistry, Oral Surgery & Medicine

miRNA-21 deficiency impairs alveolar socket healing in mice

Franz Josef Strauss et al.

JOURNAL OF PERIODONTOLOGY (2020)

Article Engineering, Biomedical

Stem cell-based bone regeneration in diseased microenvironments: Challenges and solutions

Bing-Doug Sui et al.

BIOMATERIALS (2019)

Article Cell Biology

Mediation of the Acute Stress Response by the Skeleton

Julian Meyer Berger et al.

CELL METABOLISM (2019)

Article Endocrinology & Metabolism

Depression and risk of fracture and bone loss: an updated meta-analysis of prospective studies

Q. Wu et al.

OSTEOPOROSIS INTERNATIONAL (2018)

Article Medicine, Research & Experimental

Sympathetic β1-adrenergic signaling contributes to regulation of human bone metabolism

Sundeep Khosla et al.

JOURNAL OF CLINICAL INVESTIGATION (2018)

Review Genetics & Heredity

Advances in the delivery of RNA therapeutics: from concept to clinical reality

James C. Kaczmarek et al.

GENOME MEDICINE (2017)

Article Multidisciplinary Sciences

miR-21 deficiency inhibits osteoclast function and prevents bone loss in mice

Cheng-Hu Hu et al.

SCIENTIFIC REPORTS (2017)

Article Dentistry, Oral Surgery & Medicine

microRNA-21 Contributes to Orthodontic Tooth Movement

N. Chen et al.

JOURNAL OF DENTAL RESEARCH (2016)

Article Multidisciplinary Sciences

Osteoclast-derived exosomal miR-214-3p inhibits osteoblastic bone formation

Defang Li et al.

NATURE COMMUNICATIONS (2016)

Article Cell & Tissue Engineering

Allogeneic Mesenchymal Stem Cell Therapy Promotes Osteoblastogenesis and Prevents Glucocorticoid-Induced Osteoporosis

Bingdong Sui et al.

STEM CELLS TRANSLATIONAL MEDICINE (2016)

Review Biochemistry & Molecular Biology

Targeted Delivery Systems for Molecular Therapy in Skeletal Disorders

Lei Dang et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2016)

Article Medicine, Research & Experimental

MicroRNA-188 regulates age-related switch between osteoblast and adipocyte differentiation

Chang-Jun Li et al.

JOURNAL OF CLINICAL INVESTIGATION (2015)

Article Biochemistry & Molecular Biology

LTB4 promotes insulin resistance in obese mice by acting on macrophages, hepatocytes and myocytes

Pingping Li et al.

NATURE MEDICINE (2015)

Article Endocrinology & Metabolism

Five Freely Circulating miRNAs and Bone Tissue miRNAs Are Associated With Osteoporotic Fractures

Claudine Seeliger et al.

JOURNAL OF BONE AND MINERAL RESEARCH (2014)

Article Endocrinology & Metabolism

RANKL Inhibitors Induce Osteonecrosis of the Jaw in Mice With Periapical Disease

Tara L. Aghaloo et al.

JOURNAL OF BONE AND MINERAL RESEARCH (2014)

Article Biochemistry & Molecular Biology

PDGF-BB secreted by preosteoclasts induces angiogenesis during coupling with osteogenesis

Hui Xie et al.

NATURE MEDICINE (2014)

Article Endocrinology & Metabolism

MicroRNA Functions in Osteogenesis and Dysfunctions in Osteoporosis

Andre J. van Wijnen et al.

CURRENT OSTEOPOROSIS REPORTS (2013)

Article Endocrinology & Metabolism

Deletion of β-adrenergic receptor 1, 2, or both leads to different bone phenotypes and response to mechanical stimulation

Dominique D. Pierroz et al.

JOURNAL OF BONE AND MINERAL RESEARCH (2012)

Review Endocrinology & Metabolism

MicroRNA control of bone formation and homeostasis

Jane B. Lian et al.

NATURE REVIEWS ENDOCRINOLOGY (2012)

Article Multidisciplinary Sciences

Anabolic action of parathyroid hormone regulated by the β2-adrenergic receptor

Ryo Hanyu et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2012)

Article Hematology

A microRNA expression signature of osteoclastogenesis

Toshifumi Sugatani et al.

Article Immunology

Genetic determination of the cellular basis of the sympathetic regulation of bone mass accrual

Daisuke Kajimura et al.

JOURNAL OF EXPERIMENTAL MEDICINE (2011)

Article Multidisciplinary Sciences

Sympathetic control of bone mass regulated by osteopontin

Masashi Nagao et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2011)

Review Endocrinology & Metabolism

Depression and Osteoporosis: A Research Synthesis with Meta-Analysis

G. Cizza et al.

HORMONE AND METABOLIC RESEARCH (2010)

Review Pharmacology & Pharmacy

Stress hormones: physiological stress and regulation of metabolism

Ioannis Kyrou et al.

CURRENT OPINION IN PHARMACOLOGY (2009)

Review Endocrinology & Metabolism

The molecular understanding of osteoclast differentiation

Masataka Asagiri et al.

Article Multidisciplinary Sciences

Depression induces bone loss through stimulation of the sympathetic nervous system

Raz Yirmiya et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2006)

Article Medicine, General & Internal

Effects of antihypertensive drug treatments on fracture outcomes: a meta-analysis of observational studies

M. Wiens et al.

JOURNAL OF INTERNAL MEDICINE (2006)

Article Immunology

A function for the macrophage F4/80 molecule in tolerance induction

TK van den Berg et al.

TRENDS IN IMMUNOLOGY (2005)

Article Biochemistry & Molecular Biology

The molecular clock mediates leptin-regulated bone formation

LN Fu et al.

Article Multidisciplinary Sciences

Leptin regulation of bone resorption by the sympathetic nervous system and CART

F Elefteriou et al.

NATURE (2005)

Article Oncology

RANK-Fc: A therapeutic antagonist for RANK-L in myeloma

EM Sordillo et al.

CANCER (2003)

Article Biochemistry & Molecular Biology

Leptin regulates bone formation via the sympathetic nervous system

S Takeda et al.

Article Endocrinology & Metabolism

Neuroendocrine aspects of the response to stress

DB Miller et al.

METABOLISM-CLINICAL AND EXPERIMENTAL (2002)