期刊
EXPERT REVIEW OF HEMATOLOGY
卷 15, 期 8, 页码 697-710出版社
TAYLOR & FRANCIS LTD
DOI: 10.1080/17474086.2022.2108783
关键词
Hemophilia; osteoporosis; experimental studies; clinical studies; prevention; treatment
类别
The relationship between severe hemophilia and osteoporosis has been well established. This paper reviews the available information on osteoporosis in hemophilia and emphasizes the importance of its prevention. Various preventive measures are suggested.
Introduction The relationship between severe hemophilia and osteoporosis has been well established in the literature. However, although the importance of its prevention in order to reduce the risk of bone fractures has been reported, the importance of its treatment in clinical practice has not been well analyzed. Areas covered In this paper, a review of the available clinical and experimental information on osteoporosis in hemophilia has been performed, to better understand the relationship between hemophilia and osteoporosis. Prevention of osteoporosis in hemophilia should include primary hematological prophylaxis; a diet appropriate in calcium and vitamin D; a regular exercise program that includes aerobics, strength training and balance and flexibility activities; restriction of tobacco and alcohol use; and limitation of the duration of immobilization. Expert opinion Prevention of osteoporosis in hemophilic patients is paramount. However, it is noteworthy that there is only one publication on the treatment of osteoporosis in patients with hemophilia. Until further research is done on this topic, the existing recommendations for non-hemophilic patients should be followed. They include the use of antiresorptives (estrogens, selective estrogen receptor modulators, bisphosphonates, denosumab) and anabolic agents (teriparatide, abaloparatide, romosozumab). Further studies on the management of osteoporosis in patients with hemophilia are required.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据