4.7 Article

Apigenin inhibits migration and induces apoptosis of human endometrial carcinoma Ishikawa cells via PI3K-AKT-GSK-3β pathway and endoplasmic reticulum stress

相关参考文献

注意:仅列出部分参考文献,下载原文获取全部文献信息。
Article Dentistry, Oral Surgery & Medicine

Tight junction protein CLDN17 serves as a tumor suppressor to reduce the invasion and migration of oral cancer cells by inhibiting epithelial-mesenchymal transition

Ya-Ni Xu et al.

Summary: The study revealed that CLDN17 expression is downregulated in oral cancer but higher in head and neck squamous cell carcinoma, with a correlation to TNM staging. Overexpression of CLDN17 inhibited invasion and migration of oral cancer cells by increasing CDH1 and decreasing VIM, indicating its potential as a therapeutic target in oral cancer.

ARCHIVES OF ORAL BIOLOGY (2022)

Article Oncology

Enhanced extrinsic apoptosis of therapy-induced senescent cancer cells using a death receptor 5 (DR5) selective agonist

Abel Soto-Gamez et al.

Summary: Genotoxic agents are commonly used in cancer therapy to induce cellular senescence, but senescent cancer cells may exhibit resistance to apoptosis and increase the risk of relapse. Targeting DR5 with a selective TRAIL variant has shown more effective apoptosis induction in therapy-induced senescent cancer cells compared to wild-type TRAIL, with no impact on non-cancerous cells. This suggests that DR5 targeting could be a novel therapeutic strategy to eliminate therapy-induced senescent cancer cells.

CANCER LETTERS (2022)

Article Oncology

KDM1A inhibition augments the efficacy of rapamycin for the treatment of endometrial cancer

Prabhakar Pitta Venkata et al.

Summary: The study revealed a strong synergistic effect between KDM1A inhibitors and mTOR inhibitors, showing significant reduction in cell viability and migration in EC cells with combination therapy. Inhibition of KDM1A decreased the activation of the mTOR signaling pathway and blocked rapamycin-induced feedback activation of Akt. The combination therapy could potentially serve as an effective targeted treatment for EC patients.

CANCER LETTERS (2022)

Article Genetics & Heredity

Identification of hub genes associated with EMT-induced chemoresistance in breast cancer using integrated bioinformatics analysis

Bhavjot Kaur et al.

Summary: This study identified hub genes associated with EMT and chemoresistance in breast cancer, impacting patient survival. The research found that commonly differentially expressed genes (DEGs) were involved in chemoresistance and EMT, and that EMT-induced breast cancer cells exhibited drug efflux transporter overexpression and resistance to chemotherapy. Pathway enrichment analysis revealed enrichment in immunological pathways, early endosome, protein dimerization, and proteoglycans in cancer, and identified eight hub genes from the protein-protein interaction (PPI) network.
Article Biochemistry & Molecular Biology

Etoposide-induced protein 2.4 ameliorates high glucose-induced epithelial-mesenchymal transition by activating adenosine monophosphate-activated protein kinase pathway in renal tubular cells

Fan Li et al.

Summary: In this study, it was found that EI24 expression was downregulated in diabetic mouse kidneys and high glucose-stimulated HK2 cells. Knockdown of EI24 led to EMT of HK2 cells, while overexpression of EI24 ameliorated high glucose-induced EMT via the AMPK pathway. Treatment with DNMT inhibitor 5Aza enhanced EI24 expression and alleviated EMT in high glucose-treated cells and diabetic mouse kidneys, suggesting that DNA methyltransferase-regulated EI24 may be a potential therapeutic target for diabetic renal injury.

INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY (2022)

Article Plant Sciences

Polyphyllin D induces apoptosis and protective autophagy in breast cancer cells through JNK1-Bcl-2 pathway

Jiazhe Liu et al.

Summary: The study found that Polyphyllin D (PD) can induce autophagy in breast cancer cells through activation of the JNK1/Bcl-2 pathway, and increase PD-induced cell apoptosis by inhibiting autophagy, thus achieving anti-tumor effects.

JOURNAL OF ETHNOPHARMACOLOGY (2022)

Article Cardiac & Cardiovascular Systems

Programmed cell death in aortic aneurysm and dissection: A potential therapeutic target

Abhijit Chakraborty et al.

Summary: Rupture of aortic aneurysm and dissection remains a leading cause of death, with progressive smooth muscle cell loss being a crucial feature. Understanding programmed cell death pathways is critical for preventing aortic destruction and disease progression in AAD.

JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY (2022)

Article Plant Sciences

The new andrographolide derivative AGS-30 induces apoptosis in human colon cancer cells by activating a ROS-dependent JNK signalling pathway

Zhuyun Liu et al.

Summary: The anti-cancer effect of AGS-30 is stronger than that of Andro, inducing apoptosis of colon cancer cells through ROS/JNK-dependent pathway. These findings may provide insights for the future development of derivatives of Andro as novel chemotherapeutic agents.

PHYTOMEDICINE (2022)

Article Chemistry, Analytical

Real-time and accurate monitoring of mitochondria-related apoptosis by a multifunctional two-photon fluorescent probe

Xinru Wang et al.

Summary: The designed multifunctional two-photon fluorescent probe Mito-PF can be used for real-time monitoring of mitochondria-related apoptosis, and successfully evaluated the effect of the drug bpV(phen).

SENSORS AND ACTUATORS B-CHEMICAL (2022)

Article Oncology

Cancer/testis antigen LDHC promotes proliferation and metastasis by activating the PI3K/Akt/GSK-3β-signaling pathway and the in lung adenocarcinoma

Liangyuan Chen et al.

Summary: LDHC plays a crucial role in the progression of lung adenocarcinoma, with its high expression significantly correlated with aggressive tumor features and poor prognosis. Overexpression of LDHC induces lactate and ATP production in LUAD cells, enhances invasive and metastatic potential, and accelerates tumor growth.

EXPERIMENTAL CELL RESEARCH (2021)

Article Biochemistry & Molecular Biology

Evolution of the folding landscape of effector caspases

Suman Shrestha et al.

Summary: Caspases are a family of cysteinyl proteases that control programmed cell death and maintain homeostasis in multi-cellular organisms. The apoptotic caspases evolved from a common ancestor (CA) into two distinct subfamilies: monomers (initiator caspases) or dimers (effector caspases). Differences in activation mechanisms of the two subfamilies, and their oligomeric forms, play a central role in the regulation of apoptosis. The folding landscape established with the common ancestor has been retained for over 650 million years, providing mechanisms for evolutionary changes that affect stability of extant caspases.

JOURNAL OF BIOLOGICAL CHEMISTRY (2021)

Article Chemistry, Physical

Deciphering the DNA-binding affinity, cytotoxicity and apoptosis induce as the anticancer mechanism of Bavachinin: An experimental and computational investigation

Mahvash Farajzadeh Dehkordi et al.

Summary: This study confirmed the ability of Bavachinin (BVC) to exert anticancer effects through interacting with DNA, specifically through a minor groove binding mode with ctDNA. Additionally, BVC demonstrated significant cytotoxicity and increased expression of pro-apoptotic genes in breast cancer cells. Furthermore, molecular docking studies showed a good binding affinity of BVC with pro-apoptotic proteins, suggesting its potential for medical and pharmaceutical applications.

JOURNAL OF MOLECULAR LIQUIDS (2021)

Article Medicine, Research & Experimental

Foeniculum vulgare seed extract induces apoptosis in lung cancer cells partly through the down-regulation of Bcl-2

Weiwei Ke et al.

Summary: Ethanol extract of Foeniculum vulgare seeds (EEFS) significantly reduces lung cancer cell growth by targeting Bcl-2 protein expression and inducing apoptosis in vitro and in vivo. This study provides evidence for the potential of EEFS as a therapeutic drug for lung cancer.

BIOMEDICINE & PHARMACOTHERAPY (2021)

Article Food Science & Technology

Dioscin inhibits human endometrial carcinoma proliferation via G0/G1 cell cycle arrest and mitochondrial-dependent signaling pathway

Xiao-Li Li et al.

Summary: Dioscin inhibited proliferation of human endometrial cancer Ishikawa cells by regulating cell cycle and promoting apoptosis through the mitochondrial pathway.

FOOD AND CHEMICAL TOXICOLOGY (2021)

Article Food Science & Technology

Plumbagin induces Ishikawa cell cycle arrest, autophagy, and apoptosis via the PI3K/Akt signaling pathway in endometrial cancer

Xiangsheng Zhang et al.

Summary: Plumbagin shows potential medicinal properties, including anticancer activities. It inhibits cell proliferation, blocks cell cycle, induces apoptosis and autophagy in endometrial cancer cells. The anticancer effects of PLB may be mediated by abrogating the PI3K/Akt pathway.

FOOD AND CHEMICAL TOXICOLOGY (2021)

Article Biochemistry & Molecular Biology

L-theanine suppresses the metastasis of prostate cancer by downregulating MMP9 and Snail

Xirui Fan et al.

Summary: L-theanine has been shown to inhibit invasion and migration of prostate cancer cells, as well as increase cell-cell adhesion. It also suppresses the epithelial-mesenchymal transition process in PCa. Through downregulating certain proteins and inhibiting specific signaling pathways, L-theanine shows therapeutic potential for metastatic prostate cancer.

JOURNAL OF NUTRITIONAL BIOCHEMISTRY (2021)

Article Biochemistry & Molecular Biology

Kv3 channels contribute to cancer cell migration via vimentin regulation

Hun Ju Sim et al.

Summary: This study demonstrates the significant roles of Kv3 channels in cancer cell migration by regulating vimentin and being closely related to the AKT pathway in human cervical cancer cells.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2021)

Review Oncology

Perspectives on natural compounds in chemoprevention and treatment of cancer: an update with new promising compounds

Abedul Haque et al.

Summary: Although cancer is the second deadliest disease worldwide, recent advances in precision treatments are promising. However, challenges remain due to the heterogeneity and mutational burdens of cancer cells. Chemoprevention, especially with natural dietary compounds, is considered a rational and appealing strategy to prevent carcinogenesis, particularly in high-risk populations.

EUROPEAN JOURNAL OF CANCER (2021)

Article Pharmacology & Pharmacy

PI3K/Akt/GSK-3? signal pathway is involved in P2X7 receptor-induced proliferation and EMT of colorectal cancer cells*

Wen-Jun Zhang et al.

Summary: This study revealed that P2X7 receptor plays a significant role in colorectal cancer by regulating the PI3K/Akt/GSK-3beta signaling pathway to promote cell proliferation and migration. These findings suggest that P2X7 receptor may serve as a potential therapeutic target for CRC.

EUROPEAN JOURNAL OF PHARMACOLOGY (2021)

Article Biochemistry & Molecular Biology

Apigenin enhances apoptosis induction by 5-fluorouracil through regulation of thymidylate synthase in colorectal cancer cells

Changwon Yang et al.

Summary: The study found that apigenin enhances the inhibitory effect of 5-FU on colorectal cancer cells by suppressing TS expression, promoting apoptosis, and disrupting the cell cycle. Additionally, apigenin increases reactive oxygen species production and intracellular calcium levels, indicating its potential to improve therapeutic efficacy.

REDOX BIOLOGY (2021)

Article Biochemistry & Molecular Biology

Bakuchiol, main component of root bark of Ulmus davidiana var. japonica, inhibits TGF-β-induced in vitro EMT and in vivo metastasis

Da-Eun Lee et al.

Summary: This study demonstrates that bakuchiol (BC) inhibits proliferation and metastasis of cancer cells by suppressing EMT, suggesting its potential as a therapeutic agent for treating cancers.

ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS (2021)

Article Oncology

Adjuvant Therapy for High-risk Endometrial Carcinoma

J. Perera et al.

Summary: High-risk endometrial cancers have a poorer prognosis and their survival remains relatively poor. Management strategies typically involve surgery, radiotherapy, and potentially chemotherapy, with ongoing trials aiming to better individualize treatment plans. Recent studies show benefit from adjuvant chemotherapy in more advanced stages and highlight the importance of molecular profiling in guiding treatment decisions.

CLINICAL ONCOLOGY (2021)

Article Toxicology

Cigarette smoke extracts induce apoptosis in Raw264.7 cells via endoplasmic reticulum stress and the intracellular Ca2+/P38/STAT1 pathway

Haoshen Feng et al.

Summary: Cigarette smoke extract induces apoptosis in Raw264.7 cells through endoplasmic reticulum stress and the intracellular Ca2+/P38/STAT1 pathway. The increased expression of CHOP, BiP, and P-eif2 alpha were observed, with P38 inhibitor significantly reducing apoptosis and ERK1/2 inhibitor promoting apoptosis. This study reveals the mechanisms by which cigarette smoke leads to macrophage apoptosis.

TOXICOLOGY IN VITRO (2021)

Article Food Science & Technology

Sulforaphane attenuates oxidative stress and inflammation induced by fine particulate matter in human bronchial epithelial cells

Yang Qin et al.

Summary: This study demonstrates that pretreatment with sulforaphane alleviates PM2.5-induced cell injury by suppressing oxidative stress and inflammation in human bronchial epithelial cells.

JOURNAL OF FUNCTIONAL FOODS (2021)

Article Biochemistry & Molecular Biology

Ginsenoside CK induces apoptosis of human cervical cancer HeLa cells by regulating autophagy and endoplasmic reticulum stress

Qi Yin et al.

Summary: This study revealed that Ginsenoside CK (GCK) inhibits proliferation, induces cell cycle arrest, alters ROS levels, promotes apoptosis, and affects multiple pathways in cervical cancer HeLa cells. It suggests that GCK could be a potential natural product for treating cervical cancer.

FOOD & FUNCTION (2021)

Article Food Science & Technology

Involvement of PERK-CHOP pathway in fumonisin B1-induced cytotoxicity in human gastric epithelial cells

Song Yu et al.

FOOD AND CHEMICAL TOXICOLOGY (2020)

Review Pharmacology & Pharmacy

Sesquiterpenes and their derivatives-natural anticancer compounds: An update

Tareq Abu-Izneid et al.

PHARMACOLOGICAL RESEARCH (2020)

Article Food Science & Technology

Diallyl disulfide (DADS) boosts TRAIL-Mediated apoptosis in colorectal cancer cells by inhibiting Bcl-2

Hong Jun Kim et al.

FOOD AND CHEMICAL TOXICOLOGY (2019)

Article Medicine, Research & Experimental

Inhibition of PI3K/Akt/mTOR pathway by apigenin induces apoptosis and autophagy in hepatocellular carcinoma cells

Jiali Yang et al.

BIOMEDICINE & PHARMACOTHERAPY (2018)

Review Oncology

Apigenin: A dietary flavonoid with diverse anticancer properties

Josip Madunic et al.

CANCER LETTERS (2018)

Article Food Science & Technology

Camptothecin enhances c-Myc-mediated endoplasmic reticulum stress and leads to autophagy by activating Ca2+-mediated AMPK

Rajapaksha Gedara Prasad Tharanga Jayasooriya et al.

FOOD AND CHEMICAL TOXICOLOGY (2018)

Article Medicine, Research & Experimental

IRE1α-TRAF2-ASK1 pathway is involved in CSTMP-induced apoptosis and ER stress in human non-small cell lung cancer A549 cells

Jiexia Zhang et al.

BIOMEDICINE & PHARMACOTHERAPY (2016)

Article Food Science & Technology

Chimaphilin induces apoptosis in human breast cancer MCF-7 cells through a ROS-mediated mitochondrial pathway

Wei-Dong Ma et al.

FOOD AND CHEMICAL TOXICOLOGY (2014)