4.7 Article

Apigenin inhibits migration and induces apoptosis of human endometrial carcinoma Ishikawa cells via PI3K-AKT-GSK-3β pathway and endoplasmic reticulum stress

期刊

JOURNAL OF FUNCTIONAL FOODS
卷 94, 期 -, 页码 -

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ELSEVIER
DOI: 10.1016/j.jff.2022.105116

关键词

Apigenin; Apoptosis; ER stress; Mitochondrial pathway; Migration

资金

  1. National Natural Science Foundation of Ningxia Province [2021AAC02019]

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Apigenin (API) inhibits proliferation, induces apoptosis, and prevents migration and invasion of Ishikawa cells. The study suggests that API could be a promising dietary supplement and adjuvant chemotherapeutic agent.
Several experimental and biological studies have emphasized the tumor suppression efficacy and low toxicity of Apigenin (API); however, its exact underlying mechanism on human endometrial carcinoma Ishikawa cell line (EC) is still unknown. We found that API could inhibit the proliferation of Ishikawa cells at IC50 of 45.55 mu M, arrest the cell cycle at G2/M phase, induce apoptosis by inhibiting Bcl-xl and increasing Bax, Bak and Caspases. Further, API could induce apoptosis by activating the endoplasmic reticulum (ER) stress pathway by increasing the Ca2+, ATF4, and CHOP. It could impede cell migration and invasion through PI3K-AKT-GSK-3 beta signaling pathway, preventing wound healing, restraining cells migration from the upper chamber to the lower chamber. This study demonstrated that API can be used as a promising dietary supplement and an adjuvant chemotherapeutic agent for cancer treatment.

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