期刊
JOURNAL OF FUNCTIONAL FOODS
卷 94, 期 -, 页码 -出版社
ELSEVIER
DOI: 10.1016/j.jff.2022.105122
关键词
Adiposity; Antioxidants; Cafeteria diet; Insulin; Leptin; Lipid metabolism
资金
- Coordination of Improvement of Higher Education Personnel (Coordenacao de Aperfeicoamento de Pessoal de Nivel Superior - CAPES) [001]
This study investigated the anti-adiposity effect of extra virgin coconut oil (E-VCO) on obese rats and found that E-VCO reduced body mass and adiposity index, improved hormonal parameters, and decreased liver fat accumulation. E-VCO also had positive effects on metabolic parameters.
Few studies have addressed the effect of extra virgin coconut oil (E-VCO) in obesity. Therefore, this study investigated the anti-adiposity effect of E-VCO focusing on biochemical parameters and liver health of obese rats. E-VCO contains caprilyc, capric and lauric fatty acids and rutin, 3,4-dihydroxybenzoic acid, salicylic acid as major phenolic compounds. A total of 32 male Wistar rats were randomized into four groups: healthy; healthy treated with E-VCO; obese; obese treated with E-VCO. The rats consumed a control or cafeteria diet for 16 weeks. The treated groups received 3,000 mg/kg of E-VCO via gavage. E-VCO reduced body mass and adiposity index and improved hormonal parameters. E-VCO also decreased the accumulation of liver fat, hepatic cholesterol and triglyceride levels, increased faecal cholesterol excretion and decreased faecal triglycerides excretion. E-VCO had an anti-adiposity effect and reversed changes in liver and adipose tissues induced by obesity with improvements in metabolic parameters.
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