4.6 Article

Altered Synaptic Transmission and Excitability of Cerebellar Nuclear Neurons in a Mouse Model of Duchenne Muscular Dystrophy

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Mechanisms and Consequences of Cerebellar Purkinje Cell Disinhibition in a Mouse Model of Duchenne Muscular Dystrophy

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Summary: Duchenne muscular dystrophy (DMD) is a common form of childhood muscular dystrophy caused by mutations in the dystrophin gene. This study found that dystrophin deficiency disrupts inhibitory signaling in the cerebellar circuit and firing patterns of cerebellar cells, potentially contributing to cognitive and motor deficits observed in DMD patients.

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