相关参考文献
注意：仅列出部分参考文献，下载原文获取全部文献信息。Rab7 reduces α-synuclein toxicity in rats and primary neurons
Eva M. Szego et al.
EXPERIMENTAL NEUROLOGY (2022)
Maturing Autophagosomes are Transported Towards the Cell Periphery
Anna Hilverling et al.
CELLULAR AND MOLECULAR NEUROBIOLOGY (2022)
Chemical and pharmacological characterization of the TRPML calcium channel blockers ML-SI1 and ML-SI3
Charlotte Leser et al.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (2021)
Large Acid-Evoked Currents, Mediated by ASIC1a, Accompany Differentiation in Human Dopaminergic Neurons
Andreas Neuhof et al.
FRONTIERS IN CELLULAR NEUROSCIENCE (2021)
Alpha-Synuclein defects autophagy by impairing SNAP29-mediated autophagosome-lysosome fusion
Qilin Tang et al.
CELL DEATH & DISEASE (2021)
Epigenetic inactivation of the autophagy-lysosomal system in appendix in Parkinson's disease
Juozas Gordevicius et al.
NATURE COMMUNICATIONS (2021)
Mitochondria-lysosome contacts regulate mitochondrial Ca2+ dynamics via lysosomal TRPML1
Wesley Peng et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2020)
Increased Lysosomal Exocytosis Induced by Lysosomal Ca2+ Channel Agonists Protects Human Dopaminergic Neurons from α-Synuclein Toxicity
Taiji Tsunemi et al.
JOURNAL OF NEUROSCIENCE (2019)
Rapamycin directly activates lysosomal mucolipin TRP channels independent of mTOR
Xiaoli Zhang et al.
PLOS BIOLOGY (2019)
The activation of Mucolipin TRP channel 1 (TRPML1) protects motor neurons from L-BMAA neurotoxicity by promoting autophagic clearance
Valentina Tedeschi et al.
SCIENTIFIC REPORTS (2019)
Cytosolic Trapping of a Mitochondrial Heat Shock Protein Is an Early Pathological Event in Synucleinopathies
Eva M. Szego et al.
CELL REPORTS (2019)
PIKfyve accelerates phagosome acidification through activation of TRPML1 while arrests aberrant vacuolation independent of the Ca2+ channel
Yuri Isobe et al.
JOURNAL OF BIOCHEMISTRY (2019)
TRPML1 links lysosomal calcium to autophagosome biogenesis through the activation of the CaMKKβ/VPS34 pathway
A. Scotto Rosato et al.
NATURE COMMUNICATIONS (2019)
FYCO1 mediates clearance of α-synuclein aggregates through a Rab7-dependent mechanism
Theodora Saridaki et al.
JOURNAL OF NEUROCHEMISTRY (2018)
Promoting the clearance of neurotoxic proteins in neurodegenerative disorders of ageing
Barry Boland et al.
NATURE REVIEWS DRUG DISCOVERY (2018)
Effects of ambroxol on the autophagy-lysosome pathway and mitochondria in primary cortical neurons
J. Magalhaes et al.
SCIENTIFIC REPORTS (2018)
Structural basis for PtdInsP2-mediated human TRPML1 regulation
Michael Fine et al.
NATURE COMMUNICATIONS (2018)
α-Synuclein Genetic Variability: A Biomarker for Dementia in Parkinson Disease
Ilaria Guella et al.
ANNALS OF NEUROLOGY (2016)
A familial ATP13A2 mutation enhances alpha-synuclein aggregation and promotes cell death
Tomas Lopes da Fonseca et al.
HUMAN MOLECULAR GENETICS (2016)
Autophagic lysosomal reformation depends on mTOR reactivation in H2O2-induced autophagy
Jiqian Zhang et al.
INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY (2016)
Autophagy core machinery: overcoming spatial barriers in neurons
Aileen R. Ariosa et al.
JOURNAL OF MOLECULAR MEDICINE-JMM (2016)
Rab7 induces clearance of α-synuclein aggregates
Elisabeth Dinter et al.
JOURNAL OF NEUROCHEMISTRY (2016)
A molecular mechanism to regulate lysosome motility for lysosome positioning and tubulation
Xinran Li et al.
NATURE CELL BIOLOGY (2016)
α-Synuclein-induced lysosomal dysfunction occurs through disruptions in protein trafficking in human midbrain synucleinopathy models
Joseph R. Mazzulli et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2016)
Bafilomycin A1 disrupts autophagic flux by inhibiting both V-ATPase-dependent acidification and Ca-P60A/SERCA-dependent autophagosome-lysosome fusion
Caroline Mauvezin et al.
AUTOPHAGY (2015)
BK Channels Alleviate Lysosomal Storage Diseases by Providing Positive Feedback Regulation of Lysosomal Ca2+ Release
Qi Cao et al.
DEVELOPMENTAL CELL (2015)
Lysosomal calcium signalling regulates autophagy through calcineurin and TFEB
Diego L. Medina et al.
NATURE CELL BIOLOGY (2015)
Up-regulation of lysosomal TRPML1 channels is essential for lysosomal adaptation to nutrient starvation
Wuyang Wang et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2015)
Autophagosome-lysosome fusion is independent of V-ATPase-mediated acidification
Caroline Mauvezin et al.
NATURE COMMUNICATIONS (2015)
The ML1Nx2 Phosphatidylinositol 3,5-Bisphosphate Probe Shows Poor Selectivity in Cells
Gerald R. V. Hammond et al.
PLOS ONE (2015)
Phosphatidylinositol 3,5-bisphosphate: Low abundance, high significance
Amber J. McCartney et al.
BIOESSAYS (2014)
Zn2+ dyshomeostasis caused by loss of ATP13A2/PARK9 leads to lysosomal dysfunction and alpha-synuclein accumulation
Taiji Tsunemi et al.
HUMAN MOLECULAR GENETICS (2014)
ATP13A2/PARK9 Regulates Secretion of Exosomes and α-Synuclein
Taiji Tsunemi et al.
JOURNAL OF NEUROSCIENCE (2014)
Ubiquitin is phosphorylated by PINK1 to activate parkin
Fumika Koyano et al.
NATURE (2014)
A small molecule restores function to TRPML1 mutant isoforms responsible for mucolipidosis type IV
Cheng-Chang Chen et al.
NATURE COMMUNICATIONS (2014)
Atp13a2-deficient mice exhibit neuronal ceroid lipofuscinosis, limited -synuclein accumulation and age-dependent sensorimotor deficits
Patrick J. Schultheis et al.
HUMAN MOLECULAR GENETICS (2013)
Derivation and Expansion Using Only Small Molecules of Human Neural Progenitors for Neurodegenerative Disease Modeling
Peter Reinhardt et al.
PLOS ONE (2013)
Genetically encoded fluorescent probe to visualize intracellular phosphatidylinositol 3,5-bisphosphate localization and dynamics
Xinran Li et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2013)
Autophagy in lysosomal storage disorders
Andrew P. Lieberman et al.
AUTOPHAGY (2012)
Drosophila TRPML Is Required for TORC1 Activation
Ching-On Wong et al.
CURRENT BIOLOGY (2012)
Deficiency of ATP13A2 Leads to Lysosomal Dysfunction, α-Synuclein Accumulation, and Neurotoxicity
Marija Usenovic et al.
JOURNAL OF NEUROSCIENCE (2012)
Disrupted Autophagy Leads to Dopaminergic Axon and Dendrite Degeneration and Promotes Presynaptic Accumulation of α-Synuclein and LRRK2 in the Brain
Lauren G. Friedman et al.
JOURNAL OF NEUROSCIENCE (2012)
Loss of P-type ATPase ATP13A2/PARK9 function induces general lysosomal deficiency and leads to Parkinson disease neurodegeneration
Benjamin Dehay et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2012)
Lipid storage disorders block lysosomal trafficking by inhibiting a TRP channel and lysosomal calcium release
Dongbiao Shen et al.
NATURE COMMUNICATIONS (2012)
Role of TRPML and Two-Pore Channels in Endolysosomal Cation Homeostasis
Christian Grimm et al.
JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS (2012)
Selective autophagy mediated by autophagic adapter proteins
Terje Johansen et al.
AUTOPHAGY (2011)
Molecular mechanisms of endolysosomal Ca2+ signalling in health and disease
Anthony J. Morgan et al.
BIOCHEMICAL JOURNAL (2011)
Gaucher Disease Glucocerebrosidase and α-Synuclein Form a Bidirectional Pathogenic Loop in Synucleinopathies
Joseph R. Mazzulli et al.
CELL (2011)
Sumoylation inhibits α-synuclein aggregation and toxicity
Petranka Krumova et al.
JOURNAL OF CELL BIOLOGY (2011)
Rapid, complete and large-scale generation of post-mitotic neurons from the human LUHMES cell line
Diana Scholz et al.
JOURNAL OF NEUROCHEMISTRY (2011)
Distinct Roles In Vivo for the Ubiquitin-Proteasome System and the Autophagy-Lysosomal Pathway in the Degradation of α-Synuclein
Darius Ebrahimi-Fakhari et al.
JOURNAL OF NEUROSCIENCE (2011)
Distinct Autophagosomal-Lysosomal Fusion Mechanism Revealed by Thapsigargin-Induced Autophagy Arrest
Ian G. Ganley et al.
MOLECULAR CELL (2011)
Role of TRP Channels in the Regulation of the Endosomal Pathway
Ken Abe et al.
PHYSIOLOGY (2011)
Mucolipins: Intracellular TRPML1-3 channels
Xiping Cheng et al.
FEBS LETTERS (2010)
α-Synuclein impairs macroautophagy: implications for Parkinson's disease
Ashley R. Winslow et al.
JOURNAL OF CELL BIOLOGY (2010)
Termination of autophagy and reformation of lysosomes regulated by mTOR
Li Yu et al.
NATURE (2010)
Macroautophagy is defective in mucolipin-1-deficient mouse neurons
Cyntia Curcio-Morelli et al.
NEUROBIOLOGY OF DISEASE (2010)
PI(3,5)P2 controls membrane trafficking by direct activation of mucolipin Ca2+ release channels in the endolysosome
Xian-ping Dong et al.
NATURE COMMUNICATIONS (2010)
Pre-fibrillar α-synuclein variants with impaired β-structure increase neurotoxicity in Parkinson's disease models
Damla Pinar Karpinar et al.
EMBO JOURNAL (2009)
Defective autophagy in neurons and astrocytes from mice deficient in PI(3,5)P2
Cole J. Ferguson et al.
HUMAN MOLECULAR GENETICS (2009)
Dynamics and diversity in autophagy mechanisms: lessons from yeast
Hitoshi Nakatogawa et al.
NATURE REVIEWS MOLECULAR CELL BIOLOGY (2009)
Multicenter Analysis of Glucocerebrosidase Mutations in Parkinson's Disease
E. Sidransky et al.
NEW ENGLAND JOURNAL OF MEDICINE (2009)
PIKfyve Regulation of Endosome-Linked Pathways
Jane de Lartigue et al.
TRAFFIC (2009)
Autophagic dysfunction in mucolipidosis type IV patients
Silvia Vergarajauregui et al.
HUMAN MOLECULAR GENETICS (2008)
Accumulation and clearance of α-synuclein aggregates demonstrated by time-lapse imaging
Felipe Opazo et al.
JOURNAL OF NEUROCHEMISTRY (2008)
The role of calcium and other ions in sorting and delivery in the late endocytic pathway
J. P. Luzio et al.
BIOCHEMICAL SOCIETY TRANSACTIONS (2007)
p62/SQSTM1 binds directly to Atg8/LC3 to facilitate degradation of ubiquitinated protein aggregates by autophagy
Serhiy Pankiv et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2007)
Autophagy, mitochondria and cell death in lysosomal storage diseases
Kirill Kiselyov et al.
AUTOPHAGY (2007)
Lysosomal exocytosis is impaired in mucolipidosis type IV
Janice M. LaPlante et al.
MOLECULAR GENETICS AND METABOLISM (2006)
Phosphoinositides in cell regulation and membrane dynamics
Gilbert Di Paolo et al.
NATURE (2006)
Endoplasmic reticulum stress and mitochondrial cell death pathways mediate A53T mutant alpha-synuclein-induced toxicity
WW Smith et al.
HUMAN MOLECULAR GENETICS (2005)
Characterization of the FKBP•Rapamycin•FRB ternary complex
LA Banaszynski et al.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2005)
Aggresomes formed by α-synuclein and synphilin-1 are cytoprotective
M Tanaka et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2004)
Cloning of the gene encoding a novel integral membrane protein, mucolipidin - and identification of the two major founder mutations causing mucolipidosis type IV
MT Bassi et al.
AMERICAN JOURNAL OF HUMAN GENETICS (2000)
Identification of the gene causing mucolipidosis type IV
R Bargal et al.
NATURE GENETICS (2000)
分享论文
