期刊
INTERNATIONAL JOURNAL OF ENDOCRINOLOGY
卷 2022, 期 -, 页码 -出版社
HINDAWI LTD
DOI: 10.1155/2022/6453882
关键词
-
资金
- University of Malaya, Kuala Lumpur, Malaysia [PV038-2019]
Vitamin D deficiency can lead to metabolic diseases such as obesity, hyperlipidemia, and diabetes mellitus. It impairs insulin secretion and beta-cell functions, exacerbates inflammation, oxidative stress, and apoptosis, resulting in insulin resistance and impaired glucose homeostasis.
Vitamin D deficiency is a common health problem worldwide. Despite its known skeletal effects, studies have begun to explore its extra-skeletal effects, that is, in preventing metabolic diseases such as obesity, hyperlipidemia, and diabetes mellitus. The mechanisms by which vitamin D deficiency led to these unfavorable metabolic consequences have been explored. Current evidence indicates that the deficiency of vitamin D could impair the pancreatic beta-cell functions, thus compromising its insulin secretion. Besides, vitamin D deficiency could also exacerbate inflammation, oxidative stress, and apoptosis in the pancreas and many organs, which leads to insulin resistance. Together, these will contribute to impairment in glucose homeostasis. This review summarizes the reported metabolic effects of vitamin D, in order to identify its potential use to prevent and overcome metabolic diseases.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据