Triglyceride-Glucose Index for the Diagnosis of Metabolic Syndrome: A Cross-Sectional Study of 298,652 Individuals Receiving a Health Check-Up in China

Article Cardiac & Cardiovascular Systems

Comparison of triglyceride-glucose index and HOMA-IR for predicting prevalence and incidence of metabolic syndrome

Da-Hye Son et al.

Summary: The study suggests that the TyG index is superior to the HOMA-IR index in predicting metabolic syndrome. The TyG index has a significantly better predictive power for the prevalence and incidence of MetS compared to the HOMA-IR index.

NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES (2022)

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Article Endocrinology & Metabolism

Intermediate hyperglycaemia, insulin resistance and metabolic syndrome among obese Arab children (12-17 years old) in Kuwait

Lena Davidsson et al.

Summary: The study found a significant proportion of insulin resistance, metabolic syndrome, and intermediate hyperglycemia in 97 obese Arab adolescents, with impaired fasting plasma glucose also being relatively high. This indicates the need for interventions to prevent obesity and diabetes.

PRIMARY CARE DIABETES (2021)

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Review Sport Sciences

Metabolic Syndrome Pathophysiology and Predisposing Factors

Antonio Bovolini et al.

Summary: Metabolic syndrome is a cluster of cardiometabolic risk factors with high prevalence among adult populations and elevated costs for public health systems worldwide. It is characterized by the coexistence of risk factors such as abdominal obesity, atherogenic dyslipidemia, elevated blood pressure, a prothrombotic and pro-inflammatory state, insulin resistance, and higher glucose levels. These factors are indubitably linked to an increased risk of developing chronic conditions like type 2 diabetes and cardiovascular disease.

INTERNATIONAL JOURNAL OF SPORTS MEDICINE (2021)

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Article Cardiac & Cardiovascular Systems

Increased visceral fat accumulation modifies the effect of insulin resistance on arterial stiffness and hypertension risk

Neftali Eduardo Antonio-Villa et al.

Summary: This study found that the joint effect of insulin resistance and visceral adipose tissue on endothelial functionality, arterial stiffness, and hypertension is controversial. Visceral adipose tissue acts as a mediator of insulin resistance in promoting arterial stiffness and arterial hypertension. Both insulin resistance and visceral adipose tissue should be targeted to ameliorate cardiometabolic risk.

NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES (2021)

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Review Cardiac & Cardiovascular Systems

Obesity, kidney dysfunction, and inflammation: interactions in hypertension

John E. Hall et al.

Summary: Obesity contributes significantly to human primary hypertension risk, particularly in driving cardiovascular and kidney diseases, with kidney dysfunction and neurohormonal, renal, and inflammatory mechanisms playing key roles in the development of obesity-induced hypertension.

CARDIOVASCULAR RESEARCH (2021)

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Article Clinical Neurology

Triglyceride glucose index influences platelet reactivity in acute ischemic stroke patients

Yinping Guo et al.

Summary: In acute ischemic stroke patients taking dual antiplatelet therapy, the elevation of the TyG index is associated with enhanced platelet reactivity and a higher prevalence of aspirin high residual platelet reactivity. Insulin resistance assessed by the TyG index could be an independent risk factor for aspirin high residual platelet reactivity.

BMC NEUROLOGY (2021)

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Article Cardiac & Cardiovascular Systems

Gender difference in the association between TyG index and subclinical atherosclerosis: results from the I-Lan Longitudinal Aging Study

Ya-Wen Lu et al.

Summary: The study explored the association between the TyG index and early subclinical atherosclerosis, finding a significant correlation between a high TyG index and atherosclerosis in non-diabetic patients, as well as gender disparities.

CARDIOVASCULAR DIABETOLOGY (2021)

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Article Pediatrics

Metabolic syndrome and insulin resistance in pre-pubertal children with psoriasis

Francesca Caroppo et al.

Summary: This study investigated the prevalence of metabolic syndrome and insulin resistance in 60 pre-pubertal children with psoriasis, finding that 30% had metabolic syndrome and 27% had insulin resistance. The data highlight the importance of assessing metabolic syndrome in young children with psoriasis besides adults and adolescents.

EUROPEAN JOURNAL OF PEDIATRICS (2021)

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Article Peripheral Vascular Disease

Sex difference in sympathetic nervous system activity and blood pressure in hypertensive patients

Chin-Chou Huang et al.

Summary: The study found that Chinese men with hypertension had higher sympathetic nervous system (SNS) activity than women, and SNS activity was specifically associated with 24-hour ambulatory blood pressure in men but not women. This suggests that different treatment strategies for hypertension should be considered based on the patient's sex.

JOURNAL OF CLINICAL HYPERTENSION (2021)

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Article Multidisciplinary Sciences

Prevalence and correlates of metabolic syndrome and its components in adults with psychotic disorders in Eldoret, Kenya

Edith Kwobah et al.

Summary: The prevalence of metabolic syndrome and its components is higher in patients with psychotic disorders compared to controls in Western Kenya. Age and presence of a psychotic disorder increase the risk for metabolic syndrome, while female gender, never married status, and widowed/separated/divorced status decrease the odds. There is a treatment gap for these physical disorders among patients with psychotic disorders in the study setting.

PLOS ONE (2021)

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Review Cell Biology

The Metabolic Role of GRK2 in Insulin Resistance and Associated Conditions

Daniela Sorriento et al.

Summary: Insulin resistance is a pathophysiological condition associated with obesity, glucose intolerance, dyslipidemia, and hypertension, leading to type 2 diabetes and cardiovascular diseases. Studies have identified G Protein Coupled Receptor Kinase type 2 (GRK2) as a potential therapeutic target for insulin resistance and its associated phenotypes.

CELLS (2021)

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Article Medicine, General & Internal

Atherogenic Index of Plasma, Triglyceride-Glucose Index and Monocyte-to-Lymphocyte Ratio for Predicting Subclinical Coronary Artery Disease

Yueqiao Si et al.

AMERICAN JOURNAL OF THE MEDICAL SCIENCES (2021)

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Article Peripheral Vascular Disease

The Triglyceride-Glucose Index, a Predictor of Insulin Resistance, Is Associated With Subclinical Atherosclerosis

Onur Baydar et al.

Summary: This study demonstrates a relationship between the TyG index and subclinical vessel disease, even in patients without a history of atherosclerotic cardiovascular disease or diabetes. Age and gender were identified as independent risk factors for PWV, while the triglyceride glucose index and age were found to be independent risk factors for corrected PWV.

ANGIOLOGY (2021)

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Article Cardiac & Cardiovascular Systems

Ventromedial Hypothalamus Activation Aggravates Hypertension Myocardial Remodeling Through the Sympathetic Nervous System

Yuyang Zhou et al.

Summary: The study found that activation of VMH increased systolic blood pressure and exacerbated cardiac remodeling in 2K1C hypertension rats, possibly by regulating fatty acid metabolism through the HIF-1α/PPARα/CPT-1 signaling pathway.

FRONTIERS IN CARDIOVASCULAR MEDICINE (2021)

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Article Oncology

Plasminogen activator inhibitor-1 gene promoter 4G/5G polymorphism and risks of peripherally inserted central catheter-related venous thrombosis in patients with lung cancer: a prospective cohort study

Yue Feng et al.

Summary: This study found that the PAI-1 gene variant did not have a significant influence on PICC-RVT in Chinese lung cancer patients. However, patients with higher Caprini scores and fibrinogen levels, as well as those receiving chemotherapy, are at increased risk for PICC-RVT.

SUPPORTIVE CARE IN CANCER (2021)

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Article Endocrinology & Metabolism

Insulin resistance surrogates predict hypertension plus hyperuricemia

Yaxin Li et al.

Summary: This study found that TyG index, TyG-BMI, TG/HDL-C, and METS-IR were significantly associated with hypertension plus hyperuricemia. TyG-BMI and METS-IR showed moderate discriminative ability for hypertension plus hyperuricemia.

JOURNAL OF DIABETES INVESTIGATION (2021)

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Article Multidisciplinary Sciences

Comparison of the triglyceride glucose index and blood leukocyte indices as predictors of metabolic syndrome in healthy Chinese population

Hai-Yan Lin et al.

Summary: The study revealed that in the Chinese population, the TyG index and neutrophils may be predictors of metabolic syndrome development, while total leukocytes, lymphocytes, and neutrophil-to-lymphocyte ratio were not significantly associated with incident MetS.

SCIENTIFIC REPORTS (2021)

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Article Biochemistry & Molecular Biology

Trace Element and Mineral Levels in Serum, Hair, and Urine of Obese Women in Relation to Body Composition, Blood Pressure, Lipid Profile, and Insulin Resistance

Alexey A. Tinkov et al.

Summary: The study found that obese women had significantly higher body fat percentage, blood pressure, serum triglyceride concentration, and insulin resistance, while having lower levels of certain trace elements and minerals in serum, hair, and urine. Obese women also showed significantly increased serum copper and urinary iron levels. The levels of serum copper, selenium, and zinc were significantly associated with BMI, even after adjusting for other factors.

BIOMOLECULES (2021)

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Article Biology

Prediction of Insulin Resistance by Modified Triglyceride Glucose Indices in Youth

Kyungchul Song et al.

Summary: The triglyceride glucose (TyG) index and modified TyG indices are valuable markers for predicting insulin resistance (IR) in youth, with modified TyG indices showing better diagnostic accuracy compared to the TyG index.

LIFE-BASEL (2021)

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Article Endocrinology & Metabolism

Insulin resistance, cardiovascular stiffening and cardiovascular disease

Michael A. Hill et al.

Summary: Insulin resistance is typically accompanied by metabolic insulin resistance and cardiovascular disease, including the correlation of reduced nitric oxide production leading to increased blood flow. Insulin resistance and hyperinsulinemia promote cardiovascular diseases by increasing vascular stiffness.

METABOLISM-CLINICAL AND EXPERIMENTAL (2021)

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Article Cardiac & Cardiovascular Systems

Visit-to-visit variability in the measurements of metabolic syndrome components and the risk of all-cause mortality, cardiovascular disease, and arterial stiffness

Mingyang Wu et al.

Summary: This study found that participants with high variability in metabolic parameters had increased risks of cardiovascular disease and all-cause mortality.

NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES (2021)

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Article Endocrinology & Metabolism

Metabolic Syndrome Severity Score for Predicting Cardiovascular Events: A Nationwide Population-Based Study from Korea

Yo Nam Jang et al.

Summary: A newly developed continuous MS score specifically for the Korean population has been found to be an independent predictor of ischemic stroke and MI in Korean middle-aged adults. The MS score showed superior model fitness and performance in predicting CV events compared to conventional metabolic syndrome diagnostic criteria (ATP-III).

DIABETES & METABOLISM JOURNAL (2021)

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Article Medicine, General & Internal

Effect of Intermittent Hypoxia on Metabolic Syndrome and Insulin Resistance in the General Male Population

Jung-Yup Lee et al.

Summary: The study identified a significant association between obstructive sleep apnea and insulin resistance as well as metabolic syndrome in a general healthy male population. The Apnea-hypopnea index (AHI) was found to be a potential indicator for assessing type 2 diabetes mellitus and metabolic syndrome in this population.

MEDICINA-LITHUANIA (2021)

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Article Endocrinology & Metabolism