Virucidal Activity of the Pyridobenzothiazolone Derivative HeE1-17Y against Enveloped RNA Viruses

Article Medicine, General & Internal

Molnupiravir for Oral Treatment of Covid-19 in Nonhospitalized Patients

A. Jayk Bernal et al.

Summary: This study found that early treatment with molnupiravir reduced the risk of hospitalization or death in at-risk, unvaccinated adults with Covid-19.

NEW ENGLAND JOURNAL OF MEDICINE (2022)

添加到收藏夹

Article Medicine, General & Internal

Early Remdesivir to Prevent Progression to Severe Covid-19 in Outpatients

R. L. Gottlieb et al.

Summary: In symptomatic, nonhospitalized high-risk Covid-19 patients, a 3-day course of remdesivir significantly reduced the risk of hospitalization or death compared to placebo, with acceptable safety profile.

NEW ENGLAND JOURNAL OF MEDICINE (2022)

添加到收藏夹

Review Microbiology

Characteristics of SARS-CoV-2 and COVID-19

Ben Hu et al.

Summary: This review summarizes the research progress on SARS-CoV-2 and COVID-19, including virology characteristics, pathogenesis, and recent advances in treatment methods. Furthermore, it discusses in detail the potential wildlife hosts and zoonotic origin of this emerging virus.

NATURE REVIEWS MICROBIOLOGY (2021)

添加到收藏夹

Article Chemistry, Medicinal

Sustainable, three-component, one-pot procedure to obtain active anti-flavivirus agents

Tommaso Felicetti et al.

Summary: A sustainable three-component reaction (3CR) was developed for synthesizing PBTZ analogues with broad-spectrum anti-flavivirus activity, with compound 22 identified as the best inhibitor in a new series. These results support PBTZ derivatives as promising anti-flavivirus agents for further development studies.

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (2021)

添加到收藏夹

Article Multidisciplinary Sciences

Oral prodrug of remdesivir parent GS-441524 is efficacious against SARS-CoV-2 in ferrets

Robert M. Cox et al.

Summary: Remdesivir is an antiviral drug approved for COVID-19 treatment, but its intravenous administration limits wider use. A study has shown that GS-621763, an oral prodrug of remdesivir parent nucleoside GS-441524, has good oral bioavailability and inhibits SARS-CoV-2 and variants of concern in ferrets, demonstrating therapeutic efficacy in a relevant animal model of SARS-CoV-2 infection.

NATURE COMMUNICATIONS (2021)

添加到收藏夹

Review Public, Environmental & Occupational Health

Emerging and Re-emerging Vector-Borne Infectious Diseases and the Challenges for Control: A Review

Bayissa Chala et al.

Summary: Vector-borne emerging and re-emerging diseases pose significant public health challenges globally. Interactions among pathogens, hosts, environment, and social demographic factors are key to the emergence and re-emergence of these diseases. Ongoing evolution of pathogens, population growth, urbanization, and climate change are among the factors linked with the appearance and resurgence of vector-borne infectious diseases.

FRONTIERS IN PUBLIC HEALTH (2021)

添加到收藏夹

News Item Multidisciplinary Sciences

STOCKING THE SHELVES FOR THE NEXT PANDEMIC

Elie Dolgin

NATURE (2021)

添加到收藏夹

Article Virology

Non-Nucleotide RNA-Dependent RNA Polymerase Inhibitor That Blocks SARS-CoV-2 Replication

Milan Dejmek et al.

Summary: The RNA-dependent RNA polymerase (RdRp) of SARS-CoV-2 is identified as a prime target for the development of new antivirals. Inhibitors originally discovered for flavivirus RdRp, such as HeE1-2Tyr and related derivatives, have also been found to significantly inhibit SARS-CoV-2 RdRp, as demonstrated through polymerase and cell-based antiviral assays.

VIRUSES-BASEL (2021)

添加到收藏夹

Review Biotechnology & Applied Microbiology

Selection and characterization of highly specific recombinant antibodies against West Nile Virus E protein

S. Rizzo et al.

JOURNAL OF BIOTECHNOLOGY (2020)

添加到收藏夹

Article Multidisciplinary Sciences

Structure of the RNA-dependent RNA polymerase from COVID-19 virus

Yan Gao et al.

SCIENCE (2020)

添加到收藏夹

Article Chemistry, Medicinal

Pyridobenzothiazolones Exert Potent Anti-Dengue Activity by Hampering Multiple Functions of NS5 Polymerase

Rolando Cannalire et al.

ACS MEDICINAL CHEMISTRY LETTERS (2020)

添加到收藏夹

Article Infectious Diseases

Comprehensive response to Usutu virus following first isolation in blood donors in the Friuli Venezia Giulia region of Italy: Development of recombinant NS1-based serology and sensitivity to antiviral drugs

Ilaria Caracciolo et al.

PLOS NEGLECTED TROPICAL DISEASES (2020)

添加到收藏夹

Letter Virology

Isolation and Full-Length Genome Characterization of SARS-CoV-2 from COVID-19 Cases in Northern Italy

Danilo Licastro et al.

JOURNAL OF VIROLOGY (2020)

添加到收藏夹

Review Microbiology

The continued threat of emerging flaviviruses

Theodore C. Pierson et al.

NATURE MICROBIOLOGY (2020)

添加到收藏夹

Article Biotechnology & Applied Microbiology

SARS-coronavirus-2 replication in Vero E6 cells: replication kinetics, rapid adaptation and cytopathology

Natacha S. Ogando et al.

JOURNAL OF GENERAL VIROLOGY (2020)

添加到收藏夹

Review Chemistry, Medicinal

Broad-Spectrum Flavivirus Inhibitors: a Medicinal Chemistry Point of View

Tommaso Felicetti et al.

CHEMMEDCHEM (2020)

添加到收藏夹

Article Pharmacology & Pharmacy

Broad spectrum anti-flavivirus pyridobenzothiazolones leading to less infective virions

Rolando Cannalire et al.

ANTIVIRAL RESEARCH (2019)

添加到收藏夹

Article Immunology

Lipidomimetic Compounds Act as HIV-1 Entry Inhibitors by Altering Viral Membrane Structure

Jon Ander Nieto-Garai et al.

FRONTIERS IN IMMUNOLOGY (2018)

添加到收藏夹

Article Multidisciplinary Sciences

Novel broad spectrum virucidal molecules against enveloped viruses

Valeria Cagno et al.

PLOS ONE (2018)

添加到收藏夹

Article Biology

New tools for automated high-resolution cryo-EM structure determination in RELION-3

Jasenko Zivanov et al.

ELIFE (2018)

添加到收藏夹

Review Microbiology

The Antigenic Structure of Zika Virus and Its Relation to Other Flaviviruses: Implications for Infection and Immunoprophylaxis

Franz X. Heinz et al.

MICROBIOLOGY AND MOLECULAR BIOLOGY REVIEWS (2017)

添加到收藏夹

Article Cell Biology

Broad-spectrum antiviral GS-5734 inhibits both epidemic and zoonotic coronaviruses

Timothy P. Sheahan et al.

SCIENCE TRANSLATIONAL MEDICINE (2017)

添加到收藏夹

Article Pharmacology & Pharmacy

Targeting flavivirus RNA dependent RNA polymerase through a pyridobenzothiazole inhibitor

Delia Tarantino et al.

ANTIVIRAL RESEARCH (2016)

添加到收藏夹

Article Biotechnology & Applied Microbiology

Efficient Transduction of Primary Vascular Cells by the Rare Adenovirus Serotype 49 Vector

Rachel S. Dakin et al.

HUMAN GENE THERAPY (2015)

添加到收藏夹

Article Biochemistry & Molecular Biology

CTFFIND4: Fast and accurate defocus estimation from electron micrographs

Alexis Rohou et al.

JOURNAL OF STRUCTURAL BIOLOGY (2015)

添加到收藏夹

Article Virology

Temperature dependent conformational change of dengue virus

Xinzheng Zhang et al.

CURRENT OPINION IN VIROLOGY (2015)

添加到收藏夹

Review Biochemistry & Molecular Biology

Peptide entry inhibitors of enveloped viruses: The importance of interfacial hydrophobicity

Hussain Badani et al.

BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES (2014)

添加到收藏夹

Review Pharmacology & Pharmacy

Favipiravir (T-705), a novel viral RNA polymerase inhibitor

Yousuke Furuta et al.

ANTIVIRAL RESEARCH (2013)

添加到收藏夹

Editorial Material Cell Biology

Virus entry at a glance

Yohei Yamauchi et al.

JOURNAL OF CELL SCIENCE (2013)

添加到收藏夹

Article Chemistry, Medicinal

Synthesis and antiviral activity of a series of 1′-substituted 4-aza-7,9-dideazaadenosine C-nucleosides

Aesop Cho et al.

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2012)

添加到收藏夹

Article Food Science & Technology

Lipids, curvature, and nano-medicine

Ole G. Mouritsen

EUROPEAN JOURNAL OF LIPID SCIENCE AND TECHNOLOGY (2011)

添加到收藏夹

Article Multidisciplinary Sciences

Mechanism of Inhibition of Enveloped Virus Membrane Fusion by the Antiviral Drug Arbidol

Elodie Teissier et al.

PLOS ONE (2011)

添加到收藏夹

Article Virology

Characterization of the early events in dengue virus cell entry by biochemical assays and single-virus tracking

Hilde M. van der Schaar et al.

JOURNAL OF VIROLOGY (2007)

添加到收藏夹

Article Virology

A rapid and quantitative assay for measuring antibody-mediated neutralization of West Nile virus infection

TC Pierson et al.

VIROLOGY (2006)

添加到收藏夹

Review Biochemistry & Molecular Biology

Virus entry: Open sesame

M Marsh et al.

CELL (2006)

添加到收藏夹

Article Virology

Metabolism and antiviral activity of ribavirin

WB Parker

VIRUS RESEARCH (2005)

添加到收藏夹

Article Virology

Involvement of cellular double-stranded DNA break binding proteins in processing of the recombinant adeno-associated virus genome

L Zentilin et al.

JOURNAL OF VIROLOGY (2001)

添加到收藏夹

Virucidal Activity of the Pyridobenzothiazolone Derivative HeE1-17Y against Enveloped RNA Viruses

相关参考文献

导出引文

分享论文