Sandfly-Borne Phleboviruses in Portugal: Four and Still Counting

Review Virology

Highly adaptive Phenuiviridae with biomedical importance in multiple fields

Ming-Hui Sun et al.

Summary: This paper provides an overview of the newly established virus family Phenuiviridae in Bunyavirales, which infects organisms across three kingdoms and poses significant threats to human health, livestock industry, and agriculture.

JOURNAL OF MEDICAL VIROLOGY (2022)

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Article Infectious Diseases

Human seroprevalence of Toscana virus and Sicilian phlebovirus in the southwest of Portugal

Carla Maia et al.

Summary: This study found that 5.3% of individuals tested in southwest Portugal had neutralizing antibodies against Toscana virus (TOSV), while 4.3% had antibodies against Sicilian phlebovirus (SFSV). Therefore, there is a need to raise public awareness about phleboviruses and include them in differential diagnosis for patients presenting with fever and neurological symptoms.

EUROPEAN JOURNAL OF CLINICAL MICROBIOLOGY & INFECTIOUS DISEASES (2022)

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Article Immunology

CYPRUS VIRUS INFECTION: A RARE BUT LIFE-THREATENING DIAGNOSIS IN CHILDREN

Saverio La Bella et al.

Summary: This article reports a rare case of sandfly fever caused by Cyprus virus in a 3.8-year-old Italian girl. Her symptoms included high fever, headache, decrease in the state of consciousness, apneas, and bradycardia. This case serves as a reminder to consider unconventional pathogens when evaluating similar symptoms in pediatric patients.

PEDIATRIC INFECTIOUS DISEASE JOURNAL (2022)

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Article Immunology

Infectious Toscana Virus in Seminal Fluid of Young Man Returning from Elba Island, Italy

Giulia Matusali et al.

Summary: This study reports the detection of infectious Toscana virus in the seminal fluid of a 25-year-old man from Italy returning from Elba Island. The presence of infectious virus in human semen indicates the potential for sexual transmission, adding Toscana virus to the long list of viruses detected in genital fluid.

EMERGING INFECTIOUS DISEASES (2022)

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Article Clinical Neurology

Toscana virus associated with Guillain-Barre syndrome: a case-control study

Serhat Vahip Okar et al.

Summary: This prospective study identified Toscana virus as a potential cause of GBS, with some patients showing rare clinical symptoms of symptomatic Toscana virus infections.

ACTA NEUROLOGICA BELGICA (2021)

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Article Virology

Seroprevalence of Toscana Virus and Sandfly Fever Sicilian Virus in European Bat Colonies Measured Using a Neutralization Test

Nazli Ayhan et al.

Summary: A study tested 329 bats from eight species collected in southern Spain for neutralizing antibodies specific to TOSV and SFSV, finding bats are not likely major players in the natural cycle of these sandfly-borne viruses; large breeding colonies can be used as sentinels for virus surveillance in specific locations.

VIRUSES-BASEL (2021)

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Article Virology

Thirteen Years of Phleboviruses Circulation in Lombardy, a Northern Italy Region

Elena Percivalle et al.

Summary: Phleboviruses transmitted by sandflies in the Mediterranean basin, such as TOSV and SFVs, can cause a range of symptoms in humans from asymptomatic to neuro-invasive infections. Despite gaps in knowledge, the infections are often underestimated by physicians. Further research and increased awareness of these viruses is crucial for effective diagnosis and treatment.

VIRUSES-BASEL (2021)

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Article Virology

Taxonomy of Phleboviruses, Emphasizing Those That Are Sandfly-Borne

Charles H. Calisher et al.

Summary: Sandfly-borne phleboviruses consist of three RNA genome segments and encode RNA-dependent RNA polymerase for transcription and replication. Some cause mild fevers in humans while others can lead to severe illnesses. There are 67 recognized phleboviruses listed in a table compiled by the authors based on reports and literature.

VIRUSES-BASEL (2021)

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Article Medicine, General & Internal

Toscana Virus: Ten Years of Diagnostics in Portugal

Fatima Amaro et al.

Summary: Toscana virus (TOSV) is an emerging sandfly-borne virus that can present as either febrile disease or neurological disease. Laboratory diagnosis of TOSV in Portugal is available, with only a few confirmed cases reported. The study found acute TOSV infections in serum samples, with some patients developing neurological symptoms.

ACTA MEDICA PORTUGUESA (2021)

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Article Virology

Phylogenetic Analysis of Massilia phlebovirus in Portugal

Fatima Amaro et al.

Summary: In the past two decades, molecular surveys of arboviruses have led to the discovery of several new viruses, contributing to the understanding of viral diversity and providing important epidemiological data on potential emerging viruses. This study characterized two new Massilia phlebovirus strains isolated from sandflies in Portugal through diagnostic assays, Illumina sequencing and phylogenetic inference, identifying them as reassortants and recognizing genomic variants co-circulating in the country. Further research is needed to uncover more information about the life cycle, geographic range, evolutionary forces, and public health importance of these viruses in Portugal and beyond.

VIRUSES-BASEL (2021)

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Article Virology

Update in Diagnostics of Toscana Virus Infection in a Hyperendemic Region (Southern Spain)

Sara Sanbonmatsu-Gamez et al.

Summary: This study reports 107 cases of TOSV neurological infection identified in Andalusia, Spain, with the majority of cases located in the hyperendemic region of Granada province. The research highlights the potential underdiagnosis of TOSV neurological infection and introduces an automated method for detecting related viruses, aiming to improve diagnostic efficiency and speed for such syndromes.

VIRUSES-BASEL (2021)

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Article Immunology

Incubation Period for Neuroinvasive Toscana Virus Infections

Lison Laroche et al.

Summary: Toscana virus (TOSV) is an emerging pathogen in the Mediterranean area with neuroinvasive properties in its severe form. Basic knowledge about TOSV biology is limited, prompting researchers to conduct a systematic review to estimate its incubation period, which was found to be 12.1 days.

EMERGING INFECTIOUS DISEASES (2021)

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Article Immunology

Emergence of Toscana Virus, Romania, 2017-2018

Corneliu P. Popescu et al.

Summary: We report on severe neuroinvasive infections caused by Toscana virus, identified through real-time reverse transcription PCR testing, in 8 hospitalized patients in Bucharest, Romania during the summers of 2017 and 2018. Among the 8 patients, 5 died, with sequencing revealing that the circulating virus belonged to lineage A.

EMERGING INFECTIOUS DISEASES (2021)

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Review Infectious Diseases

An update on Toscana virus distribution, genetics, medical and diagnostic aspects

N. Ayhan et al.

CLINICAL MICROBIOLOGY AND INFECTION (2020)

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Article Infectious Diseases

Testicular pain associated with clear fluid meningitis: How many cases of Toscana virus are we missing?

Helene Mascitti et al.

INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES (2020)

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Article Microbiology

Experimental Infection of Dogs with Toscana Virus and Sandfly Fever Sicilian Virus to Determine Their Potential as Possible Vertebrate Hosts

Clara Munoz et al.

MICROORGANISMS (2020)

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Article Parasitology

Phlebotomine sand flies in Southwest Germany: an update with records in new locations

Sandra Oerther et al.

PARASITES & VECTORS (2020)

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Article Virology

2020 taxonomic update for phylumNegarnaviricota(Riboviria:Orthornavirae), including the large ordersBunyaviralesandMononegavirales

Jens H. Kuhn et al.

ARCHIVES OF VIROLOGY (2020)

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Article

The Prevalence of Antibodies against Sandfly Fever Viruses and West Nile Virus in Cyprus

Gaetan Billioud et al.

Iranian Journal of Arthropod-Borne Diseases (2019)

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Article Microbiology

Antibody Response to Toscana Virus and Sandfly Fever Sicilian Virus in Cats Naturally Exposed to Phlebotomine Sand Fly Bites in Portugal

Andre Pereira et al.

MICROORGANISMS (2019)

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Article Biochemistry & Molecular Biology

MEGA X: Molecular Evolutionary Genetics Analysis across Computing Platforms

Sudhir Kumar et al.

MOLECULAR BIOLOGY AND EVOLUTION (2018)

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Review Virology

Novel and emergent sandfly-borne phleboviruses in Asia Minor: a systematic review

Koray Ergunay et al.

REVIEWS IN MEDICAL VIROLOGY (2017)

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Article Virology

Detection of Toscana virus from an adult traveler returning to Australia with encephalitis

Katherine E. Arden et al.

JOURNAL OF MEDICAL VIROLOGY (2017)

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Article Medicine, General & Internal

Guillain-Barre-like axonal polyneuropathy associated with Toscana virus infection A case report

Eugenia Rota et al.

MEDICINE (2017)

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Article Parasitology

Serological association between Leishmania infantum and sand fly fever Sicilian (but not Toscana) virus in sheltered dogs from southern Portugal

Carla Maia et al.

PARASITES & VECTORS (2017)

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Article Public, Environmental & Occupational Health

A Snapshot Avian Surveillance Reveals West Nile Virus and Evidence of Wild Birds Participating in Toscana Virus Circulation

Sabri Hacioglu et al.

VECTOR-BORNE AND ZOONOTIC DISEASES (2017)

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Article Biology

Of phlebotomines (sandflies) and viruses: a comprehensive perspective on a complex situation

Nazli Ayhan et al.

CURRENT OPINION IN INSECT SCIENCE (2017)

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Article Public, Environmental & Occupational Health

Seroprevalence of sandfly fever virus infection in military personnel on the western border of Iran

Ramin Shiraly et al.

JOURNAL OF INFECTION AND PUBLIC HEALTH (2017)

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Article Public, Environmental & Occupational Health

Seroprevalence study of Toscana virus and viruses belonging to the Sandfly fever Naples antigenic complex in central and southern Italy

Serena Marchi et al.

JOURNAL OF INFECTION AND PUBLIC HEALTH (2017)

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Article Infectious Diseases

First report of sandfly fever virus infection imported from Malta into Switzerland, October 2011

D Schultze et al.

Eurosurveillance (2017)

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Article Infectious Diseases

Characterization of antibody response in neuroinvasive infection caused by Toscana virus

A. Pierro et al.

CLINICAL MICROBIOLOGY AND INFECTION (2017)

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Article Immunology

High Rates of Neutralizing Antibodies to Toscana and Sandfly Fever Sicilian Viruses in Livestock, Kosovo

Nazli Ayhan et al.

EMERGING INFECTIOUS DISEASES (2017)

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Letter Infectious Diseases

Seroprevalence of Toscana virus in dogs from Kabylia (Algeria)

D. Tahir et al.

CLINICAL MICROBIOLOGY AND INFECTION (2016)

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Article Biotechnology & Applied Microbiology

Neutralization-based seroprevalence of Toscana virus and sandfly fever Sicilian virus in dogs and cats from Portugal

Sulaf Alwassouf et al.

JOURNAL OF GENERAL VIROLOGY (2016)

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Article Biotechnology & Applied Microbiology

Isolation, full genomic characterization and neutralization-based human seroprevalence of Medjerda Valley virus, a novel sandfly-borne phlebovirus belonging to the Salehabad virus complex in northern Tunisia

Laurence Bichaud et al.

JOURNAL OF GENERAL VIROLOGY (2016)

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Article Parasitology

Seroprevalence of vector-borne pathogens and molecular detection of Borrelia afzelii in military dogs from Portugal

Ana Margarida Alho et al.

PARASITES & VECTORS (2016)

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Article Parasitology

Seroprevalence of Toscana virus in dogs from Corsica, France

Mustapha Dahmani et al.

PARASITES & VECTORS (2016)

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Article Virology

Genetic characterization of Arrabida virus, a novel phlebovirus isolated in South Portugal

Fatima Amaro et al.

VIRUS RESEARCH (2016)

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Article Infectious Diseases

Seroprevalence of Sandfly-Borne Phleboviruses Belonging to Three Serocomplexes (Sandfly fever Naples, Sandfly fever Sicilian and Salehabad) in Dogs from Greece and Cyprus Using Neutralization Test

Sulaf Alwassouf et al.

PLOS NEGLECTED TROPICAL DISEASES (2016)

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Article Virology

Urinary detection of toscana virus nucleic acids in neuroinvasive infections

Koray Ergunay et al.

JOURNAL OF CLINICAL VIROLOGY (2015)

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Article Virology

Isolation, Genetic Characterization, and Seroprevalence of Adana Virus, a Novel Phlebovirus Belonging to the Salehabad Virus Complex, in Turkey

Cigdem Alkan et al.

JOURNAL OF VIROLOGY (2015)

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Article Microbiology

Serological Investigation of Phlebovirus Exposure in Blood Donors from the Mediterranean Province of Mersin, Turkey

Seda Tezcan et al.

MIKROBIYOLOJI BULTENI (2015)

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Article Virology

Co-circulation of a novel phlebovirus and Massilia virus in sandflies, Portugal

Fatima Amaro et al.

VIROLOGY JOURNAL (2015)

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Article Public, Environmental & Occupational Health

An Outbreak of Acute Febrile Illness Caused by Sandfly Fever Sicilian Virus in the Afar Region of Ethiopia, 2011

Abyot Bekele Woyessa et al.

AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE (2014)

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Article Infectious Diseases

Afebrile meningoencephalitis with transient central facial paralysis due to Toscana virus infection, south-eastern France, 2014

M. C. Marlinge et al.

EUROSURVEILLANCE (2014)

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Article Entomology

A summary of the evidence for the change in European distribution of phlebotomine sand flies (Diptera: Psychodidae) of public health importance

Jolyon M. Medlock et al.

JOURNAL OF VECTOR ECOLOGY (2014)

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Article Parasitology

Presence of sandfly-borne phleboviruses of two antigenic complexes (Sandfly fever Naples virus and Sandfly fever Sicilian virus) in two different bio-geographical regions of Tunisia demonstrated by a microneutralisation-based seroprevalence study in dogs

Sonia Sakhria et al.

Parasites & Vectors (2014)

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Article Public, Environmental & Occupational Health

Clinic-Epidemiologic Study of Human Infection by Granada Virus, a New Phlebovirus within the Sandfly Fever Naples Serocomplex

Jose Maria Navarro-Mari et al.

AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE (2013)

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Review Pharmacology & Pharmacy

Sandfly-borne phleboviruses of Eurasia and Africa: Epidemiology, genetic diversity, geographic range, control measures

Cigdem Alkan et al.

ANTIVIRAL RESEARCH (2013)

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Letter Infectious Diseases

Testicular involvement during Toscana virus infection: an unusual manifestation?

G. Zanelli et al.

INFECTION (2013)

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Article Biotechnology & Applied Microbiology

Characterization of the Salehabad virus species complex of the genus Phlebovirus (Bunyaviridae)

Gustavo Palacios et al.

JOURNAL OF GENERAL VIROLOGY (2013)

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Article Infectious Diseases

Toscana virus myositis and fasciitis

E. Mosnier et al.

MEDECINE ET MALADIES INFECTIEUSES (2013)

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Article Parasitology

Emergence of sandflies (Phlebotominae) in Austria, a Central European country

Wolfgang Poeppl et al.

PARASITOLOGY RESEARCH (2013)

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Article Infectious Diseases

Co-Circulation of Toscana Virus and Punique Virus in Northern Tunisia: A Microneutralisation-Based Seroprevalence Study

Sonia Sakhria et al.

PLOS NEGLECTED TROPICAL DISEASES (2013)

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Letter Immunology

Toscana Virus Isolated from Sandflies, Tunisia

Laurence Bichaud et al.

EMERGING INFECTIOUS DISEASES (2013)

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Article Infectious Diseases

Prevalence of Toscana virus antibodies in residents of Croatia

V. Punda-Polic et al.

CLINICAL MICROBIOLOGY AND INFECTION (2012)

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Article Infectious Diseases

A sandfly fever virus outbreak in the East Mediterranean region of Turkey

Selma Guler et al.

INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES (2012)

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Article Virology

A case of central nervous system infection due to a novel Sandfly Fever Virus (SFV) variant: Sandfly Fever Turkey Virus (SFTV)

Koray Ergunay et al.

JOURNAL OF CLINICAL VIROLOGY (2012)

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Article Infectious Diseases

Seroprevalence of and risk factors for Toscana and Sicilian virus infection in a sample population of Sicily (Italy)

Giuseppe Calamusa et al.

JOURNAL OF INFECTION (2012)

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Letter Clinical Neurology

Lethal encephalitis caused by the Toscana virus in an elderly patient

Susanne Bartels et al.

JOURNAL OF NEUROLOGY (2012)

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Editorial Material Clinical Neurology

ACUTE HYDROCEPHALUS DUE TO IMPAIRED CSF RESORPTION IN TOSCANA VIRUS MENINGOENCEPHALITIS

Johanna Oechtering et al.

NEUROLOGY (2012)

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Article Infectious Diseases

Prevalence of antibodies to phleboviruses and flaviviruses in Peja, Kosovo

G. Venturi et al.

CLINICAL MICROBIOLOGY AND INFECTION (2011)

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Article Infectious Diseases

Low seroprevalence of sandfly fever Sicilian virus antibodies in humans, Marseille, France

L. Bichaud et al.

CLINICAL MICROBIOLOGY AND INFECTION (2011)

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Article Infectious Diseases

A novel phlebovirus in Albanian sandflies

A. Papa et al.

CLINICAL MICROBIOLOGY AND INFECTION (2011)

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Article Neurosciences

Personality Changes After Toscana Virus (TOSV) Encephalitis in a 49-Year-Old Man: A Case Report

Daniele Serata et al.

INTERNATIONAL JOURNAL OF NEUROSCIENCE (2011)

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Article Public, Environmental & Occupational Health

Serosurvey Study of Toscana Virus in Domestic Animals, Granada, Spain

Jose Maria Navarro-Mari et al.

VECTOR-BORNE AND ZOONOTIC DISEASES (2011)

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Letter Immunology

Novel Phlebovirus in Febrile Child, Greece

Vassiliki Anagnostou et al.

EMERGING INFECTIOUS DISEASES (2011)

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Article Public, Environmental & Occupational Health

Granada Virus: a Natural Phlebovirus Reassortant of the Sandfly Fever Naples Serocomplex with Low Seroprevalence in Humans

Ximena Collao et al.

AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE (2010)

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Article Virology

Characterization of a sandfly fever Sicilian virus isolated during a sandfly fever epidemic in Turkey

Ahmet Carhan et al.

JOURNAL OF CLINICAL VIROLOGY (2010)

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Article Public, Environmental & Occupational Health

Surveillance of Arboviruses in Spanish Wetlands: Detection of New Flavi- and Phleboviruses

Maria-Paz Sanchez-Seco et al.

VECTOR-BORNE AND ZOONOTIC DISEASES (2010)

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Article Microbiology

Consensus Amplification and Novel Multiplex Sequencing Method for S Segment Species Identification of 47 Viruses of the Orthobunyavirus, Phlebovirus, and Nairovirus Genera of the Family Bunyaviridae

Amy J. Lambert et al.

JOURNAL OF CLINICAL MICROBIOLOGY (2009)

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Article Public, Environmental & Occupational Health

Massilia Virus, A Novel Phlebovirus (Bunyaviridae) Isolated from Sandflies in the Mediterranean

Remi N. Charrel et al.

VECTOR-BORNE AND ZOONOTIC DISEASES (2009)

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Article Immunology

Genetic Diversity of Toscana Virus

Ximena Collao et al.

EMERGING INFECTIOUS DISEASES (2009)

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Letter Immunology

Unusual Manifestation of Toscana Virus Infection, Spain

Sara Sanbonmatsu-Gamez et al.

EMERGING INFECTIOUS DISEASES (2009)

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Article Medicine, General & Internal

Outbreak of SandFly Fever in Central Iraq, September 2007

Shannon B. Ellis et al.

MILITARY MEDICINE (2008)

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Article Medicine, General & Internal

Sordera como secuela de meningitis por el virus Toscana

Francisco Antonio Martínez-García et al.

MEDICINA CLINICA (2008)

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Article Public, Environmental & Occupational Health

Serological evidence of arboviral infection and self-reported febrile illness among US troops deployed to Al Asad, Iraq

M. S. Riddle et al.

EPIDEMIOLOGY AND INFECTION (2008)

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Article Immunology

Sandfly fever Sicilian virus, Algeria

Arezki Izri et al.

EMERGING INFECTIOUS DISEASES (2008)

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Letter Virology

Detection of Toscana virus central nervous system infections in Sardinia island, Italy

Giulietta Venturi et al.

JOURNAL OF CLINICAL VIROLOGY (2007)

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Article Infectious Diseases

Sandfly fever virus outbreak in Cyprus

A Papa et al.

CLINICAL MICROBIOLOGY AND INFECTION (2006)

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Article Immunology

Emergence of Toscana virus in Europe

RN Charrel et al.

EMERGING INFECTIOUS DISEASES (2005)

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Article Immunology

Unusual presentation of life-threatening Toscana virus meningoencephalitis

F Baldelli et al.

CLINICAL INFECTIOUS DISEASES (2004)

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Article Virology

Detection and identification of Toscana and other phleboviruses by RT-nested-PCR assays with degenerated primers

MP Sánchez-Seco et al.

JOURNAL OF MEDICAL VIROLOGY (2003)

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Article Immunology

Serological survey of Toscana virus infections in a high-risk population in Italy

M Valassina et al.

CLINICAL AND DIAGNOSTIC LABORATORY IMMUNOLOGY (2003)

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Article Biotechnology & Applied Microbiology

Phylogenetic relationships among members of the genus Phlebovirus (Bunyaviridae) based on partial M segment sequence analyses

DY Liu et al.

JOURNAL OF GENERAL VIROLOGY (2003)

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Sandfly-Borne Phleboviruses in Portugal: Four and Still Counting

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