期刊
WORLD JOURNAL OF PEDIATRICS
卷 18, 期 8, 页码 545-552出版社
ZHEJIANG UNIV PRESS
DOI: 10.1007/s12519-022-00590-w
关键词
Acute respiratory tract infection; Children; Human adenovirus; Severe acute hepatitis; Southern China
类别
资金
- National Natural Science Foundation of China [82072264]
- Natural Science Foundation of Guangdong Province, China [2021A1515011071]
- Guangzhou School (Institute) Joint Funding Project [202102010202]
- Municipal Science and Technology Bureau Foundation of Guangzhou [201803040004]
- Guangzhou Basic Research Program - Zhongnanshan Medical Foundation of Guangdong Province [202102010364, ZNSA-2020003]
This study describes the epidemiology and subtype shifting of human adenovirus (HAdV) infection among children with acute respiratory illness in Guangzhou, China. The results showed a clear seasonal distribution of HAdV, with increased cases and a shift in dominant subtype from HAdV-3 to HAdV-7 in 2018 and 2019. The study also found an increase in mortality rate among children with severe HAdV cases.
Background Human adenovirus (HAdV) infection can cause a variety of diseases. It is a major pathogen of pediatric acute respiratory tract infections (ARIs) and can be life-threatening in younger children. We described the epidemiology and subtypes shifting of HAdV among children with ARI in Guangzhou, China. Methods We conducted a retrospective study of 161,079 children diagnosed with acute respiratory illness at the Guangzhou Women and Children's Medical Center between 2010 and 2021. HAdV specimens were detected by real-time PCR and the hexon gene was used for phylogenetic analysis. Results Before the COVID-19 outbreak in Guangzhou, the annual frequency of adenovirus infection detected during this period ranged from 3.92% to 13.58%, with an epidemic peak every four to five years. HAdV demonstrated a clear seasonal distribution, with the lowest positivity in March and peaking during summer (July or August) every year. A significant increase in HAdV cases was recorded for 2018 and 2019, which coincided with a shift in the dominant HAdV subtype from HAdV-3 to HAdV-7. The latter was associated with a more severe disease compared to HAdV-3. The average mortality proportion for children infected with HAdV from 2016 to 2019 was 0.38% but increased to 20% in severe cases. After COVID-19 emerged, HAdV cases dropped to 2.68%, suggesting that non-pharmaceutical interventions probably reduced the transmission of HAdV in the community. Conclusion Our study provides the foundation for the understanding of the epidemiology of HAdV and its associated risks in children in Southern China.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据