4.6 Review

Insights into induction of the immune response by the hepatitis B vaccine

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Article Gastroenterology & Hepatology

The impact of hepatitis B vaccination in the United States, 1999-2018

Wen-Qiang He et al.

Summary: The study demonstrates that the hepatitis B vaccine has been highly effective in preventing HBV infection since its inclusion in the infant immunization schedule in the US in 1991. For participants who received three or more doses of the vaccine, it also showed a reduction in all-cause mortality and cancer-related mortality.

HEPATOLOGY (2022)

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End stage renal disease has an early and continuous detrimental effect on regulatory T cells

Erasmia Sampani et al.

Summary: The study found that hemodialysis affects T cell subsets, including a gradual reduction of Treg cells in ESRD patients. As the duration of hemodialysis increases, lymphocyte and Treg cell counts decrease gradually, with Tregs showing a significant reduction even at the pre-dialysis stage.

NEPHROLOGY (2022)

Review Pharmacology & Pharmacy

Heplisav-B: A Hepatitis B Vaccine With a Novel Adjuvant

Caroline R. Champion

Summary: The HepB-CpG vaccine induces higher and faster immune responses in adults, especially in those who may not respond well to traditional vaccines. However, studies have shown potential adverse effects such as acute myocardial infarction, herpes zoster, and death associated with HepB-CpG. Long-term safety and immune memory persistence of HepB-CpG still need further investigation.

ANNALS OF PHARMACOTHERAPY (2021)

Article Urology & Nephrology

Influence of end stage renal disease onCD28expression and T-cell immunity

Erasmia Sampani et al.

Summary: In ESRD patients, CD4+ and CD8+ T-cell counts were significantly reduced, while CD4+ CD28null and CD8+ CD28null cells were significantly increased. The proportions of CD4+ CD28null cells were correlated with serum CRP and albumin levels.

NEPHROLOGY (2021)

Article Immunology

Enablers and barriers of maternal and neonatal immunization programs in Latin America

Alba Maria Ropero Alvarez et al.

Summary: Middle-income countries in Latin America have successfully implemented maternal and neonatal immunization programs, with key enablers including high policy acceptance, strong political will and legal frameworks ensuring free vaccine access. However, remaining barriers such as inadequate information, limited service coordination, and resource shortages highlight the need to improve the immunization journey for pregnant women and establish integrated information systems.

VACCINE (2021)

Article Multidisciplinary Sciences

The impact of the timely birth dose vaccine on the global elimination of hepatitis B

Margaret J. de Villiers et al.

Summary: Scaling up timely hepatitis B birth dose vaccination to 90% of new-borns in 110 low- and middle-income countries by 2030 could prevent 710,000 deaths in the 2020 to 2030 birth cohorts compared to status quo, with the greatest benefits in Africa. Drops in coverage due to disruptions in 2020 may lead to 15,000 additional deaths, mostly in South-East Asia and the Western Pacific. Delays in planned scale-up could lead to an additional 580,000 deaths globally in the 2020 to 2030 birth cohorts.

NATURE COMMUNICATIONS (2021)

Article Infectious Diseases

Immunogenicity and safety of a tri-antigenic versus a mono-antigenic hepatitis B vaccine in adults (PROTECT): a randomised, double-blind, phase 3 trial

Timo Vesikari et al.

Summary: This study compared the immunogenicity and safety of a tri-antigenic hepatitis B vaccine (TAV) with a mono-antigenic vaccine (MAV) in adults, showing that TAV was non-inferior to MAV in adults aged 18 years and older and superior in adults aged 45 years and older. TAV was associated with higher rates of mild or moderate injection site pain, tenderness, and myalgia, but overall safety profile was similar to MAV.

LANCET INFECTIOUS DISEASES (2021)

Article Medicine, General & Internal

Immunogenicity and Safety of a 3-Antigen Hepatitis B Vaccine vs a Single-Antigen Hepatitis B Vaccine A Phase 3 Randomized Clinical Trial

Timo Vesikari et al.

Summary: In this study, higher antibody concentrations and seroprotection rates were consistently found with 3A-HBV after 2 or 3 doses compared to 1A-HBV in adults aged 18 to 45 years old. The safety and efficacy of 3A-HBV demonstrates its utility in preventing hepatitis B in young healthy adults.

JAMA NETWORK OPEN (2021)

Review Medicine, General & Internal

HLA-DPB1 alleles in hepatitis B vaccine response A meta-analysis

Guojin Ou et al.

Summary: This meta-analysis reveals that specific HLA-DPB1 alleles are significantly associated with an increased antibody response to the HB vaccine, further elucidating the role of genetic factors in this immune response.

MEDICINE (2021)

Article Immunology

Efficacy of Birth Dose Vaccination in Preventing Mother-to-Child Transmission of Hepatitis B: A Randomized Controlled Trial Comparing Engerix-B and Sci-B-Vac

Rifaat Safadi et al.

Summary: The study compared the efficacy of two licensed hepatitis B vaccines in preventing peripartum HBV transmission, with Sci-B-Vac showing superiority over Engerix-B and inducing significantly higher anti-HBs levels.

VACCINES (2021)

Review Virology

Molecular Mechanisms during Hepatitis B Infection and the Effects of the Virus Variability

Marina Campos-Valdez et al.

Summary: Research on the immunopathogenesis and molecular mechanisms of hepatitis B virus (HBV) infection is complex, particularly due to difficulties in identifying patients at appropriate time points. Valuable data from animal and in vitro models has helped clarify some aspects of the early immune response. The diversity of HBV genotypes and variants is associated with disease development, outcomes, and treatment responses.

VIRUSES-BASEL (2021)

Article Environmental Sciences

Future Healthcare Workers and Hepatitis B Vaccination: A New Generation

Andrea Trevisan et al.

Summary: The study found that the age and sex of individuals receiving hepatitis B vaccination are significant factors affecting immune response. Additionally, the antibody titers vary depending on the time of vaccination, with females showing higher antibody levels when vaccinated after the age of one.

INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH (2021)

Article Immunology

Hepatitis B Vaccine Non-Responders Show Higher Frequencies of CD24highCD38high Regulatory B Cells and Lower Levels of IL-10 Expression Compared to Responders

Nina Koerber et al.

Summary: This study revealed higher frequencies of regulatory B cells (Breg) and lower IL-10 expression levels in second-generation hepatitis B vaccine non-responders, indicating a potential mechanism for the lack of protective antibody response following vaccination. Additionally, the decrease in Breg numbers after booster immunization with a third-generation hepatitis B vaccine suggests a positive effect of third-generation vaccines on Breg-mediated immunomodulation in non-responders.

FRONTIERS IN IMMUNOLOGY (2021)

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An Update on Hepatocellular Carcinoma in Chronic Kidney Disease

Fabrizio Fabrizi et al.

Summary: Chronic kidney disease is a major public health issue globally and patients with chronic kidney disease have a higher risk of hepatocellular cancer. Viral hepatitis is a well-known cause of HCC, particularly in CKD population. Treatment options include liver transplant, local approach, and tyrosine kinase inhibitors.

CANCERS (2021)

Article Medicine, General & Internal

Comparative Efficacy of a High-Dose vs Standard-Dose Hepatitis B Revaccination Schedule Among Patients With HIV A Randomized Clinical Trial

Jose Ignacio Vargas et al.

Summary: This study aimed to compare the efficacy of a high-dose schedule and a standard dose of HBV vaccination. The results demonstrated that the high-dose regimen achieved a higher and longer-lasting serological response in patients living with HIV, indicating it may be a more effective option for HBV revaccination.

JAMA NETWORK OPEN (2021)

Article Microbiology

Seroprevalence of hepatitis B, hepatitis C and HIV infection among patients undergoing haemodialysis in Buenos Aires, Argentina

Matias J. Pereson et al.

Summary: This study aimed to determine the seroprevalence of HBV, HCV and HIV infections in HD patients in Buenos Aires, Argentina. The results showed that infection rates with HBV and HCV remain high in HD patients, emphasizing the importance of proactive tasks for early diagnosis and treatment of infected individuals and vaccination of those with non-protective anti-HBs antibodies to reduce morbidity and mortality.

JOURNAL OF MEDICAL MICROBIOLOGY (2021)

Review Medicine, General & Internal

Isolated Anti-HBc: Significance and Management

Florian Moretto et al.

JOURNAL OF CLINICAL MEDICINE (2020)

Review Gastroenterology & Hepatology

Hepatitis B Immunization and Impact on Natural History and Cancer Incidence

Chih-Lin Lin et al.

GASTROENTEROLOGY CLINICS OF NORTH AMERICA (2020)

Review Urology & Nephrology

Current Knowledge of Vaccinations in Chronic Kidney Disease Patients

Intissar Haddiya

INTERNATIONAL JOURNAL OF NEPHROLOGY AND RENOVASCULAR DISEASE (2020)

Review Pediatrics

Elimination of Mother-to-Infant Transmission of Hepatitis B Virus: 35 Years of Experience

Fang-Ting Lu et al.

PEDIATRIC GASTROENTEROLOGY HEPATOLOGY & NUTRITION (2020)

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Factors That Influence the Immune Response to Vaccination

Petra Zimmermann et al.

CLINICAL MICROBIOLOGY REVIEWS (2019)

Article Gastroenterology & Hepatology

Persistence of HBsAg-specific antibodies and immune memory two to three decades after hepatitis B vaccination in adults

Pierre Van Damme et al.

JOURNAL OF VIRAL HEPATITIS (2019)

Article Gastroenterology & Hepatology

Molecular epidemiology of hepatitis B virus mutants associated with vaccine escape, drug resistance and diagnosis failure

Federico A. Di Lello et al.

JOURNAL OF VIRAL HEPATITIS (2019)

Article Public, Environmental & Occupational Health

Recommendations of the Advisory Committee on Immunization Practices for Use of a Hepatitis B Vaccine with a Novel Adjuvant

Sarah Schillie et al.

MMWR-MORBIDITY AND MORTALITY WEEKLY REPORT (2018)

Article Medicine, General & Internal

A Single Center Analysis of the Positivity of Hepatitis B Antibody after Neonatal Vaccination Program in Korea

Yong Joo Kim et al.

JOURNAL OF KOREAN MEDICAL SCIENCE (2017)

Editorial Material Biotechnology & Applied Microbiology

Influences of obesity on the immunogenicity of Hepatitis B vaccine

Fang Liu et al.

HUMAN VACCINES & IMMUNOTHERAPEUTICS (2017)

Letter Immunology

Immune activation, smoking, and vaccine response

Mehwish Younas et al.

Article Medicine, General & Internal

Obesity and inflammation: the linking mechanism and the complications

Mohammed S. Ellulu et al.

ARCHIVES OF MEDICAL SCIENCE (2017)

Review Infectious Diseases

Obesity: impact of infections and response to vaccines

C. Tagliabue et al.

EUROPEAN JOURNAL OF CLINICAL MICROBIOLOGY & INFECTIOUS DISEASES (2016)

Article Biotechnology & Applied Microbiology

Hepatitis B immune status in adolescents vaccinated during infancy: A retrospective cohort study from a pediatric practice in Germany

Carrie L. Anderson et al.

HUMAN VACCINES & IMMUNOTHERAPEUTICS (2016)

Article Endocrinology & Metabolism

Obesity Decreases B Cell Responses in Young and Elderly Individuals

Daniela Frasca et al.

OBESITY (2016)

Article Multidisciplinary Sciences

Factors influencing immunologic response to hepatitis B vaccine in adults

Shigui Yang et al.

SCIENTIFIC REPORTS (2016)

Review Immunology

Enhanced immune response to hepatitis B vaccination through immunization with a Pre-S1/Pre-S2/S Vaccine

Daniel Shouval et al.

MEDICAL MICROBIOLOGY AND IMMUNOLOGY (2015)

Review Immunology

The weight of obesity on the human immune response to vaccination

Scott D. Painter et al.

VACCINE (2015)

Article Biotechnology & Applied Microbiology

Characterization of an age-response relationship to GSK's recombinant hepatitis B vaccine in healthy adults: An integrated analysis

Olivier Van Der Meeren et al.

Human Vaccines & Immunotherapeutics (2015)

Review Immunology

Recent Advances of Vaccine Adjuvants for Infectious Diseases

Sujin Lee et al.

IMMUNE NETWORK (2015)

Review Immunology

Old and new adjuvants for hepatitis B vaccines

Geert Leroux-Roels

MEDICAL MICROBIOLOGY AND IMMUNOLOGY (2015)

Review Gastroenterology & Hepatology

Induced immunity against hepatitis B virus

Zeinab Nabil Ahmed Said et al.

WORLD JOURNAL OF HEPATOLOGY (2015)

Review Gastroenterology & Hepatology

Strategies to Inhibit Entry of HBV and HDV Into Hepatocytes

Stephan Urban et al.

GASTROENTEROLOGY (2014)

Article Gastroenterology & Hepatology

The Hepatitis B Vaccine Protects Re-Exposed Health Care Workers, But Does Not Provide Sterilizing Immunity

Jens M. Werner et al.

GASTROENTEROLOGY (2013)

Article Immunology

Determinants of Long-term Protection After Hepatitis B Vaccination in Infancy: A Meta-analysis

Katharina Schoenberger et al.

PEDIATRIC INFECTIOUS DISEASE JOURNAL (2013)

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Is Obesity a Risk Factor for Vaccine Non-Responsiveness?

Katherine M. Young et al.

PLOS ONE (2013)

Review Infectious Diseases

Strategies to increase responsiveness to hepatitis B vaccination in adults with HIV-1

Jennifer A. Whitaker et al.

LANCET INFECTIOUS DISEASES (2012)

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Obesity, inflammation and the immune system

Fatima Perez de Heredia et al.

PROCEEDINGS OF THE NUTRITION SOCIETY (2012)

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Immune Dysfunction in Uremia-An Update

Gerald Cohen et al.

TOXINS (2012)

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Emerging hepatitis B virus infection in vaccinated populations: a rising concern?

Tung-Hung Su et al.

EMERGING MICROBES & INFECTIONS (2012)

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New genetic associations detected in a host response study to hepatitis B vaccine

S. Davila et al.

GENES AND IMMUNITY (2010)

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Hepatitis B and Human Immunodeficiency Virus Coinfection

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HEPATOLOGY (2009)

Editorial Material Medicine, General & Internal

Development of Hepatitis B Vaccine

R. Palmer Beasley

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION (2009)

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Evaluation of the Impact of Hepatitis B Vaccination among Children Born during 1992-2005 in China

Xiaofeng Liang et al.

JOURNAL OF INFECTIOUS DISEASES (2009)

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Decreased Incidence of Hepatocellular Carcinoma in Hepatitis B Vaccinees: A 20-Year Follow-up Study

Mei-Hwei Chang et al.

JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE (2009)

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Immunological response to hepatitis B vaccination in patients with AIDS and virological response to highly active antiretroviral therapy

Leilani Paitoonpong et al.

SCANDINAVIAN JOURNAL OF INFECTIOUS DISEASES (2008)

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The global impact of vaccination against hepatitis B: A historical overview

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Vijayakumar Velu et al.

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Treatment of HBV-related liver disease in the dialysis population: reality and promises

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INTERNATIONAL JOURNAL OF ARTIFICIAL ORGANS (2001)

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Hepatitis B virus infection in dialysis patients

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AMERICAN JOURNAL OF NEPHROLOGY (2000)