4.6 Review

Crosstalk between dietary patterns, obesity and nonalcoholic fatty liver disease

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Summary: NAFLD is a growing epidemic with no approved pharmacological treatments, lifestyle modifications such as reduced caloric intake and Mediterranean diet are the standard approach. Mediterranean diet is recommended for its ease of adherence and beneficial metabolic effects, improving both steatosis and cardiovascular risk factors.

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The effect of coffee consumption on the non-alcoholic fatty liver disease and liver fibrosis: A meta-analysis of 11 epidemiological studies

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Circulating dipeptidyl peptidase-4 is independently associated with the presence and severity of NAFLD/NASH in individuals with and without obesity and metabolic disease

Ilaria Barchetta et al.

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AGA Clinical Practice Update on Lifestyle Modification Using Diet and Exercise to Achieve Weight Loss in the Management of Nonalcoholic Fatty Liver Disease: Expert Review

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Summary: NAFLD is a leading cause of chronic liver disease globally, affecting over 25% of the population. Lifestyle modification for weight loss is the primary intervention for patients with NAFLD. Evidence-based interventions and best practice advice are provided for clinical management of NAFLD.

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Shunming Zhang et al.

Summary: The study found that dietary patterns rich in animal foods or sugar were associated with a higher risk of NAFLD among Chinese adults, whereas a vegetable-rich dietary pattern was not associated.

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Relationship between dietary patterns and non-alcoholic fatty liver disease: A systematic review and meta-analysis

Shirin Hassani Zadeh et al.

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Calorie-Restricted Mediterranean and Low-Fat Diets Affect Fatty Acid Status in Individuals with Nonalcoholic Fatty Liver Disease

Danijela Ristic-Medic et al.

Summary: This study evaluated the effects of calorie-restricted Mediterranean and low-fat diets on patients with NAFLD. Both diets resulted in significant weight loss and improvements in liver status and cardiometabolic markers. The Mediterranean diet may have additional benefits compared to the low-fat diet by improving fatty acid profiles and FLI in NAFLD patients.

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Soft drink consumption and risk of nonalcoholic fatty liver disease: results from the Tianjin Chronic Low-Grade Systemic Inflammation and Health (TCLSIH) cohort study

Shunming Zhang et al.

Summary: The prospective study found an association between soft drink consumption and an increased risk of NAFLD in Chinese adults, with the risk of incident NAFLD increasing as the weekly consumption of soft drinks increased.

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Ammar Salehi-sahlabadi et al.

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Coffee Consumption and Non-alcoholic Fatty Liver Disease: An Umbrella Review and a Systematic Review and Meta-analysis

Chayanis Kositamongkol et al.

Summary: The study results indicate that regular coffee consumption is associated with a lower incidence of NAFLD in the general population, but there is still some uncertainty in the findings. However, for patients with NAFLD, coffee intake is beneficial in reducing the risk of liver fibrosis. Additionally, there were no significant differences in coffee consumption among patients with different levels of liver fibrosis.

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Leptin induces NAFLD progression through infiltrated CD8+T lymphocytes mediating pyroptotic-like cell death of hepatocytes and macrophages

Qinghui Zhang et al.

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Serum Uric Acid Is a Mediator of the Association Between Obesity and Incident Nonalcoholic Fatty Liver Disease: A Prospective Cohort Study

Qian Zhang et al.

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Chihiro Nakashita et al.

Summary: A healthy dietary pattern including frequent intake of seaweeds, vegetables, mushrooms, pulses, and potatoes and starches was associated with a lower risk of NAFLD in Japanese men. This pattern closely resembles the Japanese Washoku diet, indicating that adherence to Washoku may help prevent NAFLD.

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