期刊
WORLD JOURNAL OF GASTROENTEROLOGY
卷 28, 期 27, 页码 3314-3333出版社
BAISHIDENG PUBLISHING GROUP INC
DOI: 10.3748/wjg.v28.i27.3314
关键词
Nonalcoholic fatty liver disease; Dietary patterns; Obesity; Diet; Mediterranean diet; Nutrition; Treatment; Clinical guidance
资金
- Ministry of Education, Science and Technological Development of the Republic of Serbia [451-03-68/2022-14/200042]
The prevalence of nonalcoholic fatty liver disease (NAFLD) is rising worldwide, paralleling the epidemic of obesity. Nutrition can manage hepatic and cardiometabolic complications of NAFLD.
The prevalence of nonalcoholic fatty liver disease (NAFLD) is rising worldwide, paralleling the epidemic of obesity. The liver is a key organ for the metabolism of proteins, fats and carbohydrates. Various types of fats and carbohydrates in isocaloric diets differently influence fat accumulation in the liver parenchyma. Therefore, nutrition can manage hepatic and cardiometabolic complications of NAFLD. Even moderately reduced caloric intake, which leads to a weight loss of 5%-10% of initial body weight, is effective in improving liver steatosis and surrogate markers of liver disease status. Among dietary patterns, the Mediterranean diet mostly prevents the onset of NAFLD. Furthermore, this diet is also the most recommended for the treatment of NAFLD patients. However, clinical trials based on the dietary interventions in NAFLD patients are sparse. Since there are only a few studies examining dietary interventions in clinically advanced stages of NAFLD, such as active and fibrotic steatohepatitis, the optimal diet for patients in these stages of the disease must still be determined. In this narrative review, we aimed to critically summarize the associations between different dietary patterns, obesity and prevention/risk for NAFLD, to describe specific dietary interventions' impacts on liver steatosis in adults with NAFLD and to provide an updated overview of dietary recommendations that clinicians potentially need to apply in their daily practice.
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