期刊
VIROLOGY
卷 573, 期 -, 页码 141-150出版社
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.virol.2022.06.011
关键词
Dengue virus; Mutations; Phylogeny; Phylogeography; New lineages
类别
资金
- CONACyT [261775, 279079]
This study analyzed the genetic characteristics of dengue fever outbreaks in Mexico, finding specific genotypes of DENV-1 and DENV-2 circulating during the outbreak and identifying the emergence of new lineages. The study also suggested that the virus may have spread from coastal regions and tourist destinations.
Dengue fever is caused by four related dengue virus serotypes, DENV-1 to DENV-4, where each serotype comprises distinct genotypes and lineages. The last major outbreak in Mexico occurred during 2012 and 2013, when 112,698 confirmed cases were reported (DENV-1 and DENV-2 were predominant). Following partial E, NS2A and NS5 gene sequencing, based on the virus genome variability, we analyzed 396 DENV-1 and 248 DENV-2 gene sequences from serum samples from dengue acute clinical cases from 13 Mexican states, Mutations were identified, and their genetic variability estimated, along with their evolutionary relationship with DENV sequences sampled globally. DENV-1 genotype V and DENV-2 Asian-American genotype V were the only genotypes circulating during the outbreak. Mutations in NS2A and NS5 proteins were widely disseminated and suggested local emergence of new lineages. Phylogeographic analysis suggested viral spread occurred from coastal regions, and tourist destinations, such as Yucatan and Quintana Roo, which played important roles in disseminating these lineages.
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