期刊
VETERINARY JOURNAL
卷 285, 期 -, 页码 -出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.tvjl.2022.105843
关键词
Detection; Diagnosis; Disease; Physiology; Visualisation
资金
- Wellcome Trust [204813/Z/16/Z]
- Wellcome Trust [204813/Z/16/Z] Funding Source: Wellcome Trust
This review provides an overview of the structure, essential functions, and evidence for the role of the endothelial glycocalyx (eGlx) in disease. It highlights the lack of studies in cats and dogs and discusses techniques to aid its study in veterinary species.
The endothelial glycocalyx (eGlx) is a critically important structure lining the luminal surface of endothelial cells. There is increasing evidence, in human patients and animal models, for its crucial role in the maintenance of health. Moreover, its damage is associated with the pathogenesis of multiple disease states. This review provides readers with an overview of the eGlx; summarising its structure, essential functions, and evidence for its role in disease. We highlight the lack of studies regarding the eGlx in cats and dogs, particularly in naturally occurring diseases. Importantly, we discuss techniques to aid its study, which can be applied to veterinary species. Finally, we present targeted therapies aimed at preserving, and in some cases, restoring damaged eGlx.
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