期刊
ULTRASOUND IN MEDICINE AND BIOLOGY
卷 48, 期 10, 页码 2139-2145出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.ultrasmedbio.2022.06.006
关键词
Transcranial sonography; Substantia nigra; Parkinson disease; Subtypes; Asymmetry
资金
- Discipline Construction Supporting Project of The Second Affiliated Hospital of Soochow University [XKTJ-TD202007]
- National Key R&D Program of China [2017YFC0909100]
- Preventive Medicine Project of Jiangsu Province [Y2018105]
- Pre-research Project of the National Natural Science Foundation of the Second Affiliated Hospital of Soochow University [SDFEYGJ1709]
- Suzhou Science and Technology Plan Project [SYS2020148]
- Jiangsu Province Geriatric Clinical Technology Application Research Project [LD2021031]
This study explored the asymmetry of bilateral substantia nigra hyperechogenicity (SN+) and its relationship with clinical features in Parkinson's disease (PD). The findings revealed that SN+ asymmetry could reflect the asymmetrical characteristics of PD, and the dynamic change in SN+ asymmetry might indicate a dynamic change in motor asymmetry in PD patients.
Our study focused on three aspects to determine whether bilateral substantia nigra hyperechogenicity (SN+) is asymmetrical, whether the asymmetry of SN+ is related to the clinical features and whether there is variation in SN+ asymmetry during the progression of Parkinson disease (PD). This follow-up study included 234 patients with PD, who were divided into tremor PD (TD, n = 67) and non-tremor PD (NTD, n = 167) groups based on the Unified Parkinson's Disease Rating Scale (UPDRS) Part III. All participants underwent transcranial sonography (TCS) and clinical assessment. In both the TD and NTD groups, the initial SN+ was larger than the non-initial SN+. The initial SN+ was associated with Hoehn and Yahr (H & Y) stage, PD duration and initial UPDRS III, and the SN+ asymmetry index was associated with motor asymmetry index in the TD group. In the NTD group, the initial SN+ was associated only with initial UPDRS III. After a 5-year follow-up, the area of SN+ on both sides was gradually inclining to symmetry in the NTD group. Our study determined that SN+ asymmetry could reflect asymmetrical characteristics of PD. Furthermore, we inferred that the dynamic change in SN+ asymmetry might reflect a dynamic change in motor asymmetry in the NTD group. (E-mail: richer777@126. com) (C) 2022 World Federation for Ultrasound in Medicine & Biology. All rights reserved.
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