期刊
TRENDS IN IMMUNOLOGY
卷 43, 期 9, 页码 693-695出版社
CELL PRESS
DOI: 10.1016/j.it.2022.07.009
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- European Research Council (AdG grant MEDICI) [692789]
- European Research Council (ERC) [692789] Funding Source: European Research Council (ERC)
Mutations in DNMT3A and TET2, regulators of DNA methylation, are linked to clonal hematopoiesis and increased risk of cardiovascular disorders. Cobo et al. discovered that the loss of mitochondrial integrity, dispersion of mitochondrial DNA, and activation of ISGs in macrophages contribute to these associations.
Mutations in two antagonistic regulators of DNA methylation, DNMT3A and TET2, are associated with clonal hematopoiesis and increased risk of cardiovascular disorders. Recently, Cobo et al. traced the mechanistic bases for such links to loss of mitochondrial integrity, cytoplasmic dispersion of mitochondrial DNA, and the subsequent activation of interferon-stimulated genes (ISGs) in macrophages.
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