Clonal hematopoiesis, inflammation, and cardiovascular disorders: a mitochondrial connection

Mutations in two antagonistic regulators of DNA methylation, DNMT3A and TET2, are associated with clonal hematopoiesis and increased risk of cardiovascular disorders. Recently, Cobo et al. traced the mechanistic bases for such links to loss of mitochondrial integrity, cytoplasmic dispersion of mitochondrial DNA, and the subsequent activation of interferon-stimulated genes (ISGs) in macrophages.

Automated summary

Mutations in DNMT3A and TET2, regulators of DNA methylation, are linked to clonal hematopoiesis and increased risk of cardiovascular disorders. Cobo et al. discovered that the loss of mitochondrial integrity, dispersion of mitochondrial DNA, and activation of ISGs in macrophages contribute to these associations.