4.6 Editorial Material

ZBTB46 in ILC3: shared transcriptional infrastructure defines gut-protective capabilities

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Summary: This study defines ROR gamma t(+) immune cells in the intestine at single-cell resolution and identifies a subset of ILC3s that expresses ZBTB46, a transcription factor shared with conventional dendritic cells. ZBTB46 restrains the inflammatory properties of ILC3s and plays a non-redundant role in orchestrating intestinal health.

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