ZBTB46 in ILC3: shared transcriptional infrastructure defines gut-protective capabilities

Group 3 innate lymphoid cells (ILC3s) are distributed along the gastrointestinal tract at the interface between the immune system and the gut lumen, which carries a significant microbial burden. In a new study, Zhou et al. investigated the expression of transcription factor ZBTB46, normally thought to be restricted to classical dendritic cells (cDCs), and discovered that ZBTB46 expression by ILC3s in the mouse colon forms an essential part of the gastrointestinal armory to calibrate inflammatory responses.

Automated summary

In a new study, researchers discovered that the expression of transcription factor ZBTB46 in ILC3s in the mouse colon plays a crucial role in regulating inflammatory responses.