NRCAM acts as a prognostic biomarker and promotes the tumor progression in gastric cancer via EMT pathway

Article Medical Laboratory Technology

MiR-363-3p promotes prostate cancer tumor progression by targeting Dickkopf 3

Li-zhe Xu et al.

Summary: miR-363-3p promotes prostate cancer growth, migration, and invasion by targeting DKK3, while dampening apoptosis.

JOURNAL OF CLINICAL LABORATORY ANALYSIS (2022)

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Article Biochemistry & Molecular Biology

STAT3 promotes peritoneal metastasis of gastric cancer by enhancing mesothelial-mesenchymal transition

Hongkui Yang et al.

Summary: Activated STAT3 expression was found to be elevated in tumor tissues of gastric cancer patients, particularly those with peritoneal metastasis. Deactivating STAT3 suppressed proliferation, metastatic potential, and peritoneal metastasis of GC cells. These findings suggest that STAT3 activation plays a crucial role in promoting peritoneal metastasis of gastric cancer.

BIOLOGICAL CHEMISTRY (2021)

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Article Cell Biology

HMGA1B/2 transcriptionally activated-POU1F1 facilitates gastric carcinoma metastasis via CXCL12/CXCR4 axis-mediated macrophage polarization

Cheng Tang et al.

Summary: The study revealed that upregulated POU1F1 in both GC tissues and cell lines was positively correlated with poor prognosis. POU1F1 promoted GC progression by regulating macrophage proliferation, migration, polarization, and angiogenesis in a CXCL12/CXCR4-dependent manner. Furthermore, POU1F1 also promoted GC metastasis in the lung by modulating macrophage polarization via the CXCL12/CXCR4 axis in vivo.

CELL DEATH & DISEASE (2021)

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Article Oncology

Establishment of a prognostic model of four genes in gastric cancer based on multiple data sets

Liqiang Zhou et al.

Summary: This study established a reliable prognostic model for gastric cancer using bioinformatics, including a four-gene signature, with internal and external validation showing the model's reliability, and a nomogram was constructed to verify its accuracy.

CANCER MEDICINE (2021)

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Article Biochemistry & Molecular Biology

Dextran-Curcumin Nanosystems Inhibit Cell Growth and Migration Regulating the Epithelial to Mesenchymal Transition in Prostate Cancer Cells

Emilia Bevacqua et al.

Summary: The study demonstrates the enhanced efficacy of curcumin when immobilized in nanoparticles, as well as the synergistic effect with Doxorubicin for prostate cancer treatment. In vitro data provides a proof of principle for the design of an effective therapy.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

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Article Medicine, General & Internal