期刊
TETRAHEDRON LETTERS
卷 103, 期 -, 页码 -出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tetlet.2022.153992
关键词
Antioxidant; Copper; Organoselenium; Pyrazoles
资金
- FAPERGS [ARD 19/2551-0001258-6, PqG 17/2551-0000987-8]
- CNPq [309013/2019-4]
- Coordenacao de Aperfeicoamento de Pessoal de Nivel Superior -Brasil (CAPES) [001]
This study presents a simple and efficient method for the one-pot synthesis of 5-amino-4-(arylselanyl)-1H-pyrazoles catalyzed by CuI/bpy. The obtained compounds showed promising antioxidant effects in various in vitro trials, indicating their potential in protecting against oxidative diseases.
We describe herein a simple and efficient method for the sequential one-pot synthesis of 5-amino-4-(arylselanyl)-1H-pyrazoles catalyzed by CuI/bpy under mild conditions. The starting materials are easily available benzoylacetonitriles, substituted hydrazines and diaryl diselenides. A range of substituted 5-amino-4-(arylselanyl)-1H-pyrazoles was obtained in moderate to good yields (49% to 90%). Moreover, we report the antioxidant effect of the 5-amino-4-(arylselanyl)-1H-pyrazoles in several in vitro trials, which is extremely important, because oxidative stress is a crucial role in the development of various human diseases. Our data revealed that all compounds demonstrated promising effects in scavenging the synthetic radical ABTS+, presented reducing power in ferric ion reducing antioxidant power (FRAP) assay, and ability to inhibit linoleic acid peroxidation. Thus, these compounds can be interesting synthetic molecules in the protection from oxidative diseases.(c) 2022 Elsevier Ltd. All rights reserved.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据