4.4 Article

Biocatalyts: Catalysts of the future for organic synthesis and beyond?

相关参考文献

注意:仅列出部分参考文献,下载原文获取全部文献信息。
Review Chemistry, Multidisciplinary

Shortening Synthetic Routes to Small Molecule Active Pharmaceutical Ingredients Employing Biocatalytic Methods

Stefan Simic et al.

Summary: Biocatalysis, using enzymes for organic synthesis, is a powerful tool for the synthesis of active pharmaceutical ingredients (APIs). Developments in molecular biology methods have led to the rapid development of process-stable enzymes through directed evolution. Enzymes are widely employed in the synthesis of small molecule APIs, enabling more efficient and sustainable routes.

CHEMICAL REVIEWS (2022)

Review Chemistry, Multidisciplinary

Biocatalysis making waves in organic chemistry

Ulf Hanefeld et al.

Summary: Biocatalysis has had a significant impact on chemical synthesis, influencing the development of organic chemistry. Currently, hydrolases are widely used on an industrial scale, and other enzyme classes are gaining attention for solving synthetic challenges in organic chemistry. The combined efforts of various fields will establish a new toolbox for chemistry. Recent developments in this area are being critically reviewed.

CHEMICAL SOCIETY REVIEWS (2022)

Article Multidisciplinary Sciences

Machine learning-aided engineering of hydrolases for PET depolymerization

Hongyuan Lu et al.

Summary: Plastic waste is an ecological challenge, and enzymatic degradation offers a potentially green and scalable route for plastic recycling. Engineered PETase shows superior activity in hydrolyzing postconsumer PET, and a closed-loop recycling process is demonstrated.

NATURE (2022)

Review Chemistry, Multidisciplinary

Biocatalysis: Enzymatic Synthesis for Industrial Applications

Shuke Wu et al.

Summary: Biocatalysis is widely used as an alternative to chemical catalysis in various fields, with enzymes playing a key role in organic synthesis, particularly in the production of chiral compounds for pharmaceuticals and flavors. Biocatalysts are also utilized on a large scale for the production of specialty and bulk chemicals. This review focuses on scalable chemical production using enzymes, discussing opportunities, limitations, and emerging enzyme classes through illustrative examples.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2021)

Article Chemistry, Multidisciplinary

Engineered Ribosyl-1-Kinase Enables Concise Synthesis of Molnupiravir, an Antiviral for COVID-19

John A. McIntosh et al.

Summary: To meet the high demand and urgency for the investigational antiviral agent molnupiravir in treating COVID-19, a novel biocatalytic cascade was developed with engineered enzymes to significantly shorten the synthesis time by 70% and increase yield by approximately 7-fold compared to the initial route. This biocatalytic approach is expected to have broad applications for simplifying nucleoside synthesis.

ACS CENTRAL SCIENCE (2021)

Review Biochemistry & Molecular Biology

Enzymatic strategies for asymmetric synthesis

Melanie Hall

Summary: Enzymes have gained momentum at the turn of the 21st century, especially in synthetic organic chemistry, where they are increasingly being applied in a variety of processes. Synthetic chemists are recognizing the value of enzymes for their selectivity, paving the way for their use in asymmetric synthesis. The field has matured over the past two decades, proposing a panel of catalytically diverse enzymes for stereoselective reactions, enantioselective replacements, and atroposelective reactions.

RSC CHEMICAL BIOLOGY (2021)

Article Chemistry, Physical

Enzymatic Lactone-Carbene C-H Insertion to Build Contiguous Chiral Centers

Andrew Z. Zhou et al.

ACS CATALYSIS (2020)

Article Multidisciplinary Sciences

An engineered PET depolymerase to break down and recycle plastic bottles

V. Tournier et al.

NATURE (2020)

Article Chemistry, Physical

Stereoselective Enzymatic Synthesis of Heteroatom-Substituted Cyclopropanes

Oliver F. Brandenberg et al.

ACS CATALYSIS (2018)

Article Biochemistry & Molecular Biology

A serine-substituted P450 catalyzes highly efficient carbene transfer to olefins in vivo

Pedro S. Coelho et al.

NATURE CHEMICAL BIOLOGY (2013)

Review Multidisciplinary Sciences

Engineering the third wave of biocatalysis

U. T. Bornscheuer et al.

NATURE (2012)

Review Chemistry, Multidisciplinary

Challenges in the directed evolution of stereoselective enzymes for use in organic chemistry

M. T. Reetz et al.

COMPTES RENDUS CHIMIE (2011)

Review Chemistry, Multidisciplinary

Applications of biotransformations and biocatalysis to complexity generation in organic synthesis

Tomas Hudlicky et al.

CHEMICAL SOCIETY REVIEWS (2009)

Article Biochemistry & Molecular Biology

Directed Evolution and Structural Characterization of a Simvastatin Synthase

Xue Gao et al.

CHEMISTRY & BIOLOGY (2009)

Article Chemistry, Organic

Daucus carota Mediated-Reduction of Cyclic 3-Oxo-amines

Romain Lacheretz et al.

ORGANIC LETTERS (2009)

Article Multidisciplinary Sciences

Dispelling the myths - Biocatalysis in industrial synthesis

HE Schoemaker et al.

SCIENCE (2003)

Review Biotechnology & Applied Microbiology

Directed evolution and the creation of enantioselective biocatalysts

KE Jaeger et al.

APPLIED MICROBIOLOGY AND BIOTECHNOLOGY (2001)