期刊
SYNTHESIS-STUTTGART
卷 54, 期 21, 页码 4827-4833出版社
GEORG THIEME VERLAG KG
DOI: 10.1055/a-1894-9073
关键词
supercritical carbon dioxide; Kolbe-Schmitt; C-H carboxylation; metal free; solvent free
资金
- South African National Research Foundation [137961, 145774, 120419]
A simple method for the direct carboxylation of resorcinols, phenols, and indoles has been reported. The use of supercritical carbon dioxide as an electrophile and solvent under basic conditions yields moderate to high amounts of products. This method eliminates the need for solvents and metals, and avoids the cumbersome exclusion of air or water.
A straightforward site-selective method for the direct carboxylation of resorcinols (3-hydroxyphenol derivatives), phenols, and indoles is reported. The products were obtained in moderate to high yields using supercritical carbon dioxide as an electrophile and solvent under basic conditions. This method offers solvent and metal free conditions without the cumbersome exclusion of air or water with convenient purification.
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