Organic Base-Mediated Carboxylation of (Hetero)aromatic Compounds Using Supercritical Carbon Dioxide (scCO2)

A straightforward site-selective method for the direct carboxylation of resorcinols (3-hydroxyphenol derivatives), phenols, and indoles is reported. The products were obtained in moderate to high yields using supercritical carbon dioxide as an electrophile and solvent under basic conditions. This method offers solvent and metal free conditions without the cumbersome exclusion of air or water with convenient purification.

Automated summary

A simple method for the direct carboxylation of resorcinols, phenols, and indoles has been reported. The use of supercritical carbon dioxide as an electrophile and solvent under basic conditions yields moderate to high amounts of products. This method eliminates the need for solvents and metals, and avoids the cumbersome exclusion of air or water.