期刊
SURGERY FOR OBESITY AND RELATED DISEASES
卷 18, 期 11, 页码 1286-1297出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.soard.2022.06.286
关键词
Morbid obesity; Gastric bypass; RYGB animal model; Gut physiology; Small bowel
类别
资金
- University of Basel
- Department of Surgery, University Hospital Basel
- Nikolaus and Bertha Burckhardt Burgin-Stiftung
- Research Fund for Excellent Junior Researchers of the University of Basel
- Swiss National Science Foundation, Switzerland [PZ00P3_161135]
- Goldschmidt-Jacobson Foundation
- Jubilaumsstiftung Swiss Life
- Olga Mayenfisch Foundation
- Foundation Basler Diabetesgesellschaft
- Swiss National Science Foundation (SNF) [PZ00P3_161135] Funding Source: Swiss National Science Foundation (SNF)
In obese mice, a longer biliopancreatic limb (BPL) is associated with enhanced weight loss and improved glucose tolerance. However, its effects on hepatic steatosis and adipose tissue inflammation are not significant. Additionally, bariatric surgery dramatically alters gut microbiota.
Background: Roux-en-Y gastric bypass (RYGB) results in long-term weight loss and reduced obesity related co-morbidities. However, little is known about how the lengths of the biliopancreatic limb (BPL), the alimentary limb (AL), and the common limb (CL) affect weight loss and glucose metabolism. Objectives: Our aim was to establish a RYGB obese mouse model with defined proportions of the AL and BPL and a constant CL to assess the effects on weight loss,glucose metabolism, and obesity-related co-morbidities. Setting: In vivo mouse study. Methods: Six-week-old male C57BL/6J mice fed with a high-fat diet (HFD) underwent bariatric surgery with defined BPL lengths: a very long, long, and short BPL (35%, 25%, and 15% of total bowel length), or sham surgery. The length of the AL was adjusted to achieve the same CL length. Mice were analyzed for weight loss, glycemic control, and obesity-related co-morbidities. Results: Mice undergoing RYGB surgery with a very long BPL had excessive weight loss and mortal-ity and were therefore not further analyzed. Mice with a long BPL showed a significantly increased total weight loss when compared with mice with a short BPL. In addition, a long BPL improved glucose tolerance, particularly early after surgery. A long BPL was also associated with lower triglyceride levels. Resolution of hepatic steatosis and adipose tissue inflammation was, however, not statistically significant. Of note, bariatric surgery dramatically changed gut microbiota, regardless of limb length. Conclusion: In obese mice, a long BPL results in enhanced weight loss and improved glucose toler-ance. These findings could potentially be translated to humans by tailoring the BPL length according to body weight, obesity-related co-morbidities, and total bowel length of an individual patient. (c) 2022 American Society for Metabolic and Bariatric Surgery. Published by Elsevier Inc. All rights reserved.
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