期刊
SURGERY
卷 172, 期 4, 页码 1202-1209出版社
MOSBY-ELSEVIER
DOI: 10.1016/j.surg.2022.04.036
关键词
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类别
资金
- FCSR-Fronzaroli
- Gioja Bianca Costanza Fund
This study evaluated surgical indications and complications in patients with low-grade intraductal papillary mucinous neoplasms. The results showed a decrease in the rate of patients undergoing surgery for low-grade intraductal papillary mucinous neoplasms and a high incidence of postoperative complications.
Background: Surgical resection of intraductal papillary mucinous neoplasms is based on preoperative high-risk stigmata/worrisome features, but the risk of overtreatment remains high. The aim of this study was to evaluate surgical indications and perioperative and long-term complications in patients with low-grade intraductal papillary mucinous neoplasms. Methods: Patients who underwent surgical resection between 2009 and 2018 with a final histology of low-grade intraductal papillary mucinous neoplasms were included. Surgical indications, type of surgery, and short- and long-term outcomes were evaluated. Results: A significant decrease in the rate of patients resected for low-grade intraductal papillary mucinous neoplasms was observed (43.6% in 2009-2012 vs 27.8% in 2013-2018; P =.003), and 133 patients were finally included (62 women, median age: 68 years). Of these, 24.1% had 1 worrisome feature, 39.8% had >= 2 worrisome features, 18.8% had >= 1 high-risk stigmata, and 15.8% had >= 1 worrisome features thorn 1 high-risk stigmata. Overall surgical morbidity was 55.6%, 15.8% had Clavien-Dindo >= 3 complications, reoperation rate was 3.8%, and 90-day postoperative mortality was 1.5%. After a median follow-up of 60 months, 13 patients (11.5%) had a recurrence of benign intraductal papillary mucinous neoplasm in the pancreatic remnant, and 2 patients (1.8%) developed pancreatic ductal adenocarcinoma. After partial pancreatectomy, 51.3% of patients were taking pancreatic enzyme replacement therapy. Among nondiabetics, 26% developed diabetes after partial pancreatectomy, of which 38% were insulin-dependent. Eighteen patients (13.7%) developed incisional hernia. Conclusion: Given the rates of morbidity and long-term complications after pancreatic resections, surgeons should attentively balance the true risks of intraductal papillary mucinous neoplasm degeneration with the risks of surgical resection in each patient. (c) 2022 Elsevier Inc. All rights reserved.
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