In this study, Tichy and colleagues designed improved light-activated chimeric GPCRs with increased sensitivity and tunable signaling features, utilizing high-resolution GPCR-G protein complex structures.
Engineered signaling proteins permit precise modulation of cell signaling networks and are valuable tools for basic and translational research. In this issue of Structure, Tichy and colleagues leverage high-resolution GPCR-G protein complex structures to rationally design improved light-activated chimeric GPCRs (termed OptoXRs) with increased sensitivity and tunable signaling features.
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