期刊
STROKE
卷 53, 期 10, 页码 3222-3234出版社
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1161/STROKEAHA.121.037869
关键词
collateral circulation; ischemic stroke; magnetic resonance imaging; reperfusion; tomography
资金
- Netherlands Cardiovascular Research Initiative, an initiative from the Dutch Heart Foundation
The extent of collateral circulation in patients with acute ischemic stroke affects their clinical outcomes, and a good collateral circulation is associated with greater benefit of thrombolysis and endovascular treatment. Computed tomography and magnetic resonance imaging allow for rapid assessment of collateral extent and cerebral perfusion, however, the importance of collateral circulation in clinical decision-making may be underestimated due to the use of coarse and rater-dependent grading methods.
Clinical outcomes of patients with acute ischemic stroke depend in part on the extent of their collateral circulation. A good collateral circulation has also been associated with greater benefit of intravenous thrombolysis and endovascular treatment. Treatment decisions for these reperfusion therapies are increasingly guided by a combination of clinical and imaging parameters, particularly in later time windows. Computed tomography and magnetic resonance imaging enable a rapid assessment of both the collateral extent and cerebral perfusion. Yet, the role of the collateral circulation in clinical decision-making is currently limited and may be underappreciated due to the use of rather coarse and rater-dependent grading methods. In this review, we discuss determinants of the collateral circulation in patients with acute ischemic stroke, report on commonly used and emerging neuroimaging techniques for assessing the collateral circulation, and discuss the therapeutic and prognostic implications of the collateral circulation in relation to reperfusion therapies for acute ischemic stroke.
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