4.2 Article

Oxidative potential of two Brazilian endophytic fungi from Handroanthus impetiginosus towards progesterone

期刊

STEROIDS
卷 187, 期 -, 页码 -

出版社

ELSEVIER SCIENCE INC
DOI: 10.1016/j.steroids.2022.109101

关键词

Endophytic fungi; Steroids; Biotransformation; CG-MS

资金

  1. Bahia Research Foundation (FAPESB)
  2. Brazilian National Council for Scientific and Technological Development (CNPq)
  3. Bahia Research Foundation (FAPESB)
  4. Brazilian Coordination for Improvement of Personnel Higher Education (CAPES)

向作者/读者索取更多资源

Biotransformation is a method for performing uncommon chemical reactions under ecofriendly conditions, and endophytic fungi can produce diverse compounds through metabolism and obtain new steroidal derivatives from underexplored habitats.
Biotransformation has been successfully employed to conduct uncommon reactions, which would hardly be carried out by chemical synthesis. A wide diversity of compounds may be metabolized by fungi, leading to chemical derivatives through selective reactions that work under ecofriendly conditions. Endophytic fungi live inside vegetal tissues without causing damage to the host plant, making available unique enzymes for interesting chemical derivatization. Biotransformation of steroids by endophytic fungi may provide new derivatives as these microorganisms came from uncommon and underexplored habitats. In this study, endophytic strains isolated from Handroanthus impetiginosus leaves were assayed for biotransformation of progesterone, and its derivatives were identified through GC-EI-MS analysis. The endophyte Talaromyces sp. H4 was capable of transforming the steroidal nucleus selectively into four products through selective ene-reduction of the C4-C5 double bond and C-17 oxidation. The best conversion rate of progesterone (> 90 %) was reached with Penicillium citrinum H7 endophytic strain that transformed the substrate into one derivative. The results highlight endophytic fungi's potential to obtain new and interesting steroidal derivatizations.

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