期刊
SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
卷 275, 期 -, 页码 -出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.saa.2022.121147
关键词
Minoxidil; Silver nanoparticles; Oxidation; Deoxygenation; Pyrimidine N-oxide; Resonance Rayleigh scattering
类别
资金
- School of Science, King Mongkut's Institute of Technology Ladkrabang [2564-02-05-020]
This work presents a new method for detecting minoxidil using silver nanoparticles (AgNPs) oxidation. The change in resonance Rayleigh scattering (RRS) intensity was linearly related to the concentration of minoxidil, with a detection limit of 0.35 mM. The method is simple and rapid, making it suitable for quantifying minoxidil in topical hair-growth formulations.
This work presents a new method for minoxidil detection based on silver nanoparticle (AgNP) oxidation. Minoxidil, which is a pyrimidine N-oxide, can be reduced to its corresponding pyrimidine via a redox reaction. In this system, acetate buffer serves as a proton source. AgNPs act as electron donors that contribute electrons to the reaction, producing Ag+. Consequently, the sizes and numbers of AgNPs in the system decrease, which results in a decline in their resonance Rayleigh scattering (RRS). By monitoring the RRS intensity at 409 nm, a change in intensity was linearly related to the minoxidil concentration over a concentration range of 0.5 - 5.0 mM. The detection limit was 0.35 mM. This approach is simple and rapid. It is done by directly mixing the drug and AgNPs in an acidic buffer. The reaction was completed within 2 min. This proposed method was successfully utilized for quantification of minoxidil in topical hair-growth formulations. (C) 2022 Published by Elsevier B.V.
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