期刊
SOCIAL COGNITIVE AND AFFECTIVE NEUROSCIENCE
卷 17, 期 12, 页码 1068-1081出版社
OXFORD UNIV PRESS
DOI: 10.1093/scan/nsac042
关键词
cerebellum; affect; bipolar disorder; depression; pseudobulbar affect
资金
- National Institute of Health [R01HD099165, R01 MH091113, R21 HD098509, 2R56MH091113-11]
This manuscript reviews the literature on affective disturbances observed in individuals with cerebellar lesions and proposes a theoretical model based on cerebellar connectivity to explain how the cerebellum calibrates affect.
The cerebellum is one-third the size of the cerebrum yet holds twice the number of neurons. Historically, its sole function was thought to be in the calibration of smooth movements through the creation and ongoing modification of motor programs. This traditional viewpoint has been challenged by findings showing that cerebellar damage can lead to striking changes in non-motor behavior, including emotional changes. In this manuscript, we review the literature on clinical and subclinical affective disturbances observed in individuals with lesions to the cerebellum. Disorders include pathological laughing and crying, bipolar disorder, depression and mixed mood changes. We propose a theoretical model based on cerebellar connectivity to explain how the cerebellum calibrates affect. We conclude with actionable steps for future researchers to test this model and improve upon the limitations of past literature.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据