Attention to the other's body sensations modulates the ventromedial prefrontal cortex

Theory of Mind (ToM) is involved in experiencing the mental states and/or emotions of others. A further distinction can be drawn between emotion and perception/sensation. We investigated the mechanisms engaged when participants' attention is driven toward specific states. Accordingly, 21 right-handed healthy individuals performed a modified ToM task in which they reflected about someone's emotion or someone's body sensation, while they were in a functional magnetic resonance imaging scanner. The analysis of brain activity evoked by this task suggests that the two conditions engage a widespread common network previously found involved in affective ToM (temporo-parietal junction (TPJ), parietal cortex, dorso-lateral prefrontal cortex (DLPFC), medial- prefrontal cortex (MPFC), Insula). Critically, the key brain result is that body sensation implicates selectively ventromedial prefrontal cortex (VMPFC). The current findings suggest that only paying attention to the other's body sensations modulates a self-related representation (VMPFC).

Automated summary

Theory of Mind (ToM) is the process of experiencing the mental states and/or emotions of others. In this study, the mechanisms involved in directing participants' attention towards specific states were investigated using functional magnetic resonance imaging (fMRI). The analysis of brain activity evoked by the modified ToM task revealed a widespread common network involved in affective ToM, as well as selective involvement of the ventromedial prefrontal cortex (VMPFC) in body sensation.