期刊
SMALL
卷 18, 期 37, 页码 -出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/smll.202203400
关键词
cancer therapy; catalytic mechanisms; catalase CAT-like nanozymes; classifications
类别
资金
- National Key Research and Development Program of China [2021YFA1200904, 2020YFA0710700]
- National Natural Science Foundation of China [31971311, 21727817]
- Innovation Program for IHEP [E25455U210]
The field of nanozymes has witnessed rapid development, and CAT-like nanozymes in particular, as crucial regulators of reactive oxygen species, have attracted extensive research interest. Compared to other nanozymes, CAT-like nanozymes possess unique properties and find wide applications in fields such as tumor therapy and disease treatment. Therefore, a systematic discussion on CAT-like nanozymes is of great significance.
The field of nanozymes has developed rapidly over the past decade. Among various oxidoreductases mimics, catalase (CAT)-like nanozyme, acting as an essential part of the regulation of reactive oxygen species (ROS), has attracted extensive research interest in recent years. However, CAT-like nanozymes are not as well discussed as other nanozymes such as peroxidase (POD)-like nanozymes, etc. Compared with natural catalase or artificial CAT enzymes, CAT-like nanozymes have unique properties of low cost, size-dependent properties, high catalytic activity and stability, and easy surface modification, etc., which make them widely used in various fields, especially in tumor therapy and disease treatment. Consequently, there is a great requirement to make a systematic discussion on CAT-like nanozymes. In this review, some key aspects of CAT-like nanozymes are deeply summarized as: 1) Typical CAT-like nanozymes classified by different nanomaterials; 2) The catalytic mechanisms proposed by experimental and theoretical studies; 3) Extensive applications in regard to tumor therapy, cytoprotection and sensing. Therefore, it is prospected that this review will contribute to the further design of CAT-like nanozymes and optimize their applications with much higher efficiency than before.
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