期刊
SMALL
卷 18, 期 31, 页码 -出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/smll.202202921
关键词
band-edge redox potentials; low intensity ultrasound; semiconductor heterojunctions; sonodynamic therapy; sonosensitizers
类别
资金
- National Natural Science Foundation of China (NSFC) [81922035, 81871399]
- Shanghai Science and Technology Biomedical Innovation Funds [19441904200]
- Program of Shanghai Academic Research Leader [20XD1423700]
- Natural Science Foundation of Shanghai [20ZR1462100]
- Fundamental Research Funds for the Central Universities (Young Hundred-Talent Program of Tongji University)
This study demonstrates the importance of the reduction potential state of sonosensitizers in reactive oxygen species (ROS) generation. The reduction potential of band-edge is found to be critical, especially when aligned with the reduction of oxygen. Additionally, ultrasound-generated oxidation holes are effective in consuming overexpressed glutathione, enhancing cellular oxidative stress and inducing tumor cell death. The intrinsic fluorescence property of semiconductors provides imaging capability and guides the sonodynamic therapy (SDT) process.
Sonosensitizers-assisted sonodynamic therapy (SDT) has been emerging as a promising treatment for cancers, and yet few specific regulations of band structure of sonosensitizers have been reported in relation to oxygen in tissues. Herein, by a gradient doping technique to modulate the band structure of hetero-semiconductor nanorods, it is found that the reduction potential of band-edge is very critical to reactive oxygen species (ROS) production under low-intensity ultrasound (US) irradiation and particularly, when aligned with the reduction of oxygen, ROS generation is found to be most significantly enhanced. Withal, US-generated oxidation holes are found to be effective in consuming overexpressed glutathione in tumor lesions, which amplifies cellular oxidative stress and finally induces tumor cell death. Moreover, the intrinsic fluorescence property of semiconductors provides imaging capability to illumine tumor area and guide the SDT process. This study demonstrates that the reduction potential state of sonosensitizers is of crucial importance in ROS generation and the proposed reduction potential-tailored hetero-semiconductor nanorods materialize low-intensity US irradiation yet highly effective SDT and synergetic hole therapy of tumors with imaging guidance and reduced radiation injury.
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