期刊
SLEEP MEDICINE
卷 96, 期 -, 页码 119-121出版社
ELSEVIER
DOI: 10.1016/j.sleep.2022.05.007
关键词
Obstructive sleep apnea; Positive airway pressure; Angiopoietin-2; Lung injury
资金
- NIH [R01 HL137234, R01 HL106041, R35 HL135818, K23HL150301, RC2 HL101417, U34 HL105277]
- Pulmonary Fibrosis Foundation Scholars Award
This study assessed the impact of positive airway pressure (PAP) therapy on alveolar epithelial and endothelial injury and extracellular matrix remodeling in patients with obstructive sleep apnea (OSA). The findings suggest a possible adverse impact of PAP therapy on vascular endothelium.
Background: Obstructive sleep apnea (OSA) has been identified as a possible contributor to interstitial lung disease. While positive airway pressure (PAP) is effective therapy for OSA, it causes large increases in lung volumes during the night that are potentially deleterious, analogous to ventilator-induced lung injury, although this has not been previously studied. The goal of this study was to assess the impact of PAP therapy on four biomarkers of alveolar epithelial and endothelial injury and extracellular matrix remodeling in patients with OSA. Methods: In 82 patients with moderate to severe OSA who were adherent to PAP therapy, surfactant protein D, osteopontin, angiopoietin-2, and matrix metalloprotease-7 were measured by ELISA in serum samples collected before and 3-to 6-months after initiation of PAP therapy. Results: An increase in angiopoietin-2 level of 0.28 ng/mL following PAP therapy was observed (p = 0.007). This finding was replicated in an independent sample of OSA patients. No significant change was detected in surfactant protein D, osteopontin, or matrix metalloprotease-7. Conclusions: This finding raises concern for a possible adverse impact of PAP therapy on vascular endothelium. Published by Elsevier B.V.
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