4.6 Review

Necroptosis, Pyroptosis, Ferroptosis in Sepsis and Treatment

相关参考文献

注意:仅列出部分参考文献,下载原文获取全部文献信息。
Article Biochemistry & Molecular Biology

Serum NLRP3: A biomarker for identifying high-risk septic patients

Wei Huang et al.

Summary: This study found that serum NLRP3 levels can serve as a potential inflammatory biomarker to predict the status of septic patients, particularly those with septic shock. Higher NLRP3 levels were associated with increased mortality rate.

CYTOKINE (2022)

Article Immunology

NLRP3 knockout enhances immune infiltration and inflammatory responses and improves survival in a burn sepsis model

Mile Stanojcic et al.

Summary: The activation of NLRP3 inflammasome enhances tissue-specific inflammatory responsiveness in burn sepsis, leading to improved bacterial clearance and survival rates in animal models. However, Nlrp3 genetic ablation paradoxically increases acute immune infiltration and inflammation, potentially impacting patient outcomes in septic burn patients.

IMMUNOLOGY (2022)

Article Biochemistry & Molecular Biology

Hydrogen sulfide attenuates ferroptosis and stimulates autophagy by blocking mTOR signaling in sepsis-induced acute lung injury

Jianhua Li et al.

Summary: GYY4137 alleviates septicemia-induced ferroptosis and inhibits autophagy activation in ALI by increasing the expression of GPx4 and SLC7A11 and blocking mTOR signaling pathway.

MOLECULAR IMMUNOLOGY (2022)

Review Cell Biology

Ferroptosis: a cell death connecting oxidative stress, inflammation and cardiovascular diseases

Yi Yu et al.

Summary: Ferroptosis is a newly identified iron-dependent cell death mechanism that differs from other cell death pathways, characterized by lipid peroxidation and accumulation of redox-active iron. Studies suggest that ferroptosis plays a crucial role in various cardiovascular diseases, and targeting ferroptosis may present a novel therapeutic approach in treating these conditions.

CELL DEATH DISCOVERY (2021)

Article Infectious Diseases

Serum citrullinated histone H3 concentrations differentiate patients with septic verses non-septic shock and correlate with disease severity

Yuzi Tian et al.

Summary: The study showed that levels of CitH3 are elevated in patients with septic shock and correlates with PAD2 and PAD4 concentrations, disease severity, and prognosis. Furthermore, higher serum concentrations of CitH3 at 24 hours and 48 hours were found in septic patients who did not survive, suggesting a potential role of CitH3 as a prognostic biomarker for septic shock.

INFECTION (2021)

Article Immunology

Nitrosonisoldipine is a selective inhibitor of inflammatory caspases and protects against pyroptosis and related septic shock

Qianyue Chen et al.

Summary: The study identified nitrosonisoldipine (NTS) as a selective inhibitor of inflammatory caspases, blocking both noncanonical and canonical pyroptotic pathways, with potential therapeutic value for sepsis.

EUROPEAN JOURNAL OF IMMUNOLOGY (2021)

Review Immunology

The immunology of sepsis

Tom van der Poll et al.

Summary: Sepsis is a life-threatening condition caused by infection-induced organ dysfunction, characterized by unbalanced hyperinflammation and immune suppression. Current research aims to stratify sepsis patients into more similar subgroups to better identify those who are likely to benefit from specific immune interventions.

IMMUNITY (2021)

Article Cell Biology

Necroptosis is active and contributes to intestinal injury in a piglet model with lipopolysaccharide challenge

Yulan Liu et al.

Summary: Necroptosis, a newly discovered form of programmed cell death, plays a role in intestinal injury during sepsis. An inhibitor of necroptosis, Nec-1, has a preventive effect on intestinal injury.

CELL DEATH & DISEASE (2021)

Article Immunology

Distinct cell death markers identified in critical care patient survivors diagnosed with sepsis

Chandra Shekar Mallarpu et al.

Summary: The study revealed significantly elevated levels of non-apoptotic cell death markers in sepsis patient survivors compared to healthy controls, providing a basis for further investigations into the role of these markers in predicting clinical outcomes in sepsis.

IMMUNOLOGY LETTERS (2021)

Article Biotechnology & Applied Microbiology

Ferrostatin-1 alleviates lipopolysaccharide-induced cardiac dysfunction

Zheng Xiao et al.

Summary: This study demonstrates that Fer-1 can improve sepsis-induced cardiac dysfunction through multiple mechanisms, such as inhibiting ferroptosis, reducing cardiac damage and inflammatory responses.

BIOENGINEERED (2021)

Article Immunology

Circulating CitH3 Is a Reliable Diagnostic and Prognostic Biomarker of Septic Patients in Acute Pancreatitis

Baihong Pan et al.

Summary: The study revealed that CitH3 concentration significantly increased in septic acute pancreatitis patients, and was closely correlated with disease severity and clinical outcomes. CitH3 may potentially serve as a diagnostic and prognostic biomarker for septic AP.

FRONTIERS IN IMMUNOLOGY (2021)

Review Immunology

Ferroptosis in infection, inflammation, and immunity

Xin Chen et al.

Summary: Ferroptosis is a form of regulated cell death triggered by iron toxicity, lipid peroxidation, and plasma membrane damage, and plays a role in shaping the immune response in health and disease.

JOURNAL OF EXPERIMENTAL MEDICINE (2021)

Article Immunology

Protective Effects of Dexmedetomidine on Sepsis-Induced Vascular Leakage by Alleviating Ferroptosis via Regulating Metabolic Reprogramming

Han She et al.

Summary: This study indicates that Dex protects against vascular leakage following sepsis by inhibiting ferroptosis. The mechanism is mainly related to metabolic reprogramming achieved through up-regulation of Nrf2 and inhibition of mitochondrial fission.

JOURNAL OF INFLAMMATION RESEARCH (2021)

Article Critical Care Medicine

Memantine Alleviates Acute Lung Injury Via Inhibiting Macrophage Pyroptosis

Hongdou Ding et al.

Summary: Acute lung injury (ALI) is caused by direct pulmonary insults and indirect systemic inflammatory responses. Alveolar macrophages play a critical role in ALI, influencing its development through the release of inflammatory mediators. Inflammation and cell death form an auto-amplification loop, exacerbating inflammation in ALI. Pharmacological manipulation of alveolar macrophage death signals may serve as a potential therapeutic strategy.
Article Multidisciplinary Sciences

Association of plasma level of high-mobility group box-1 with necroptosis and sepsis outcomes

Hongseok Yoo et al.

Summary: The study revealed that plasma HMGB1 levels were associated with the severity and mortality of sepsis, and showed positive correlations with necroptosis-related proteins like RIPK3 and MLKL. This suggests a potential connection between HMGB1 and necroptosis.

SCIENTIFIC REPORTS (2021)

Review Medicine, General & Internal

The Role of Ferroptosis in Acute Respiratory Distress Syndrome

Mengdi Qu et al.

Summary: ?Ferroptosis is a newly discovered type of regulated cell death characterized by iron-dependent lipid peroxidation. It is involved in the pathological development of various diseases and recent studies suggest its potential as a therapeutic target for acute lung injury/acute respiratory distress syndrome.

FRONTIERS IN MEDICINE (2021)

Review Biochemistry & Molecular Biology

Signaling pathways and intervention therapies in sepsis

Yun-yu Zhang et al.

Summary: Sepsis is a life-threatening organ dysfunction caused by dysregulated host systemic inflammatory and immune response to infection. Advanced understanding of host-microorganism interaction has led to new definitions and therapeutic approaches. Research focus has shifted from pathogenicity of microorganisms to the molecular basis of host responses.

SIGNAL TRANSDUCTION AND TARGETED THERAPY (2021)

Article Biochemistry & Molecular Biology

Magnesium protects against sepsis by blocking gasdermin D N-terminal-induced pyroptosis

Dingyu Wang et al.

CELL DEATH AND DIFFERENTIATION (2020)

Article Biochemistry & Molecular Biology

RIPK3 collaborates with GSDMD to drive tissue injury in lethal polymicrobial sepsis

Hui Chen et al.

CELL DEATH AND DIFFERENTIATION (2020)

Article Critical Care Medicine

Linkage of alterations in systemic iron homeostasis to patients' outcome in sepsis: a prospective study

Anna Brandtner et al.

JOURNAL OF INTENSIVE CARE (2020)

Article Biochemistry & Molecular Biology

Ferritinophagy-mediated ferroptosis is involved in sepsis-induced cardiac injury

Ning Li et al.

FREE RADICAL BIOLOGY AND MEDICINE (2020)

Article Immunology

Caspse-11-GSDMD pathway is required for serum ferritin secretion in sepsis

Dan Wang et al.

CLINICAL IMMUNOLOGY (2019)

Review Cell Biology

The molecular machinery of regulated cell death

Daolin Tang et al.

CELL RESEARCH (2019)

Article Critical Care Medicine

Circulating Gasdermin-D in Critically Ill Patients

Elie Homsy et al.

CRITICAL CARE MEDICINE (2019)

Review Biochemistry & Molecular Biology

Arachidonic Acid Metabolism and Kidney Inflammation

Tianqi Wang et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2019)

Review Biochemistry & Molecular Biology

Programmed necrotic cell death of macrophages: Focus on pyroptosis, necroptosis, and parthanatos

Nirmal Robinson et al.

REDOX BIOLOGY (2019)

Article Gastroenterology & Hepatology

Necrostatin-1 accelerates time to death in a rat model of cecal ligation and puncture and massively increases hepatocyte caspase-3 cleavage

Qin Zhang et al.

AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY (2019)

Article Medicine, General & Internal

Erastin Inhibits Septic Shock and Inflammatory Gene Expression via Suppression of the NF-κB Pathway

Byung Moo Oh et al.

JOURNAL OF CLINICAL MEDICINE (2019)

Article Biochemistry & Molecular Biology

Neutrophil pyroptosis: new perspectives on sepsis

Lu Liu et al.

CELLULAR AND MOLECULAR LIFE SCIENCES (2019)

Article Biochemistry & Molecular Biology

Selenium unmasks protective iron armor: A possible defense against cutaneous inflammation and cancer

Jack L. Arbiser et al.

BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS (2018)

Article Medicine, Research & Experimental

RIP kinase 1-dependent endothelial necroptosis underlies systemic inflammatory response syndrome

Matija Zelic et al.

JOURNAL OF CLINICAL INVESTIGATION (2018)

Article Medicine, Research & Experimental

RIPK3 promotes sepsis-induced acute kidney injury via mitochondrial dysfunction

Angara Sureshbabu et al.

JCI INSIGHT (2018)

Article Medicine, Research & Experimental

Caspase-11-mediated endothelial pyroptosis underlies endotoxemia-induced lung injury

Kwong Tai Cheng et al.

JOURNAL OF CLINICAL INVESTIGATION (2017)

Article Immunology

Inflammasome gene profile is modulated in septic patients, with a greater magnitude in non-survivors

K. F. Esquerdo et al.

CLINICAL AND EXPERIMENTAL IMMUNOLOGY (2017)

Article Medicine, General & Internal

The Third International Consensus Definitions for Sepsis and Septic Shock (Sepsis-3)

Mervyn Singer et al.

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION (2016)

Article Multidisciplinary Sciences

Inflammasome-activated gasdermin D causes pyroptosis by forming membrane pores

Xing Liu et al.

NATURE (2016)

Review Medicine, General & Internal

Endothelial barrier dysfunction in septic shock

S. M. Opal et al.

JOURNAL OF INTERNAL MEDICINE (2015)

Article Multidisciplinary Sciences

RIPK3 promotes cell death and NLRP3 inflammasome activation in the absence of MLKL

Kate E. Lawlor et al.

NATURE COMMUNICATIONS (2015)

Review Medicine, General & Internal

Necroptosis

Andreas Linkermann et al.

NEW ENGLAND JOURNAL OF MEDICINE (2014)

Article Critical Care Medicine

Mortality and quality of life in the five years after severe sepsis

Brian H. Cuthbertson et al.

CRITICAL CARE (2013)

Article Critical Care Medicine

Inflammasome-regulated Cytokines Are Critical Mediators of Acute Lung Injury

Tamas Dolinay et al.

AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE (2012)

Article Multidisciplinary Sciences

FADD prevents RIP3-mediated epithelial cell necrosis and chronic intestinal inflammation

Patrick-Simon Welz et al.

NATURE (2011)