期刊
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
卷 136, 期 -, 页码 27-37出版社
ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
DOI: 10.1016/j.semcdb.2022.06.004
关键词
Germline; Stem cells; Differentiation; Ribosome biogenesis; Translation
The ability of ribosomes to translate mRNAs into proteins is crucial for life. Reduction in ribosome levels can have tissue-specific effects on cell fate and developmental transitions, leading to ribosomopathies. Model systems like Drosophila and C. elegans oogenesis have been used to study the impact of dysregulated ribosome homeostasis on stem cell differentiation and development. This review explores the influence of ribosome levels on stem cells, the role of ribosomal modifications and protein paralogs in development, and the ways in which cells with perturbed ribosome biogenesis are eliminated.
The ability of ribosomes to translate mRNAs into proteins is the basis of all life. While ribosomes are essential for cell viability, reduction in levels of ribosomes can affect cell fate and developmental transitions in a tissue specific manner and can cause a plethora of related diseases called ribosomopathies. How dysregulated ribosomes homeostasis influences cell fate and developmental transitions is not fully understood. Model systems such as Drosophila and C. elegans oogenesis have been used to address these questions since defects in conserved steps in ribosome biogenesis result in stem cell differentiation and developmental defects. In this review, we first explore how ribosome levels affect stem cell differentiation. Second, we describe how ribosomal modifications and incorporation of ribosomal protein paralogs contribute to development. Third, we summarize how cells with perturbed ribosome biogenesis are sensed and eliminated during organismal growth.
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