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Targeting BET bromodomains for cancer treatment
Marie Jung et al.
EPIGENOMICS (2015)
EZH2 promotes progression of small cell lung cancer by suppressing the TGF-beta-Smad-ASCL1 pathway
Fumihiko Murai et al.
CELL DISCOVERY (2015)
Small Cell Lung Cancer: Where Do We Go From Here?
Lauren Averett Byers et al.
CANCER (2015)
Targets in small cell lung cancer
Beverly A. Teicher
BIOCHEMICAL PHARMACOLOGY (2014)
Rapamycin Rescues ABT-737 Efficacy in Small Cell Lung Cancer
Eric E. Gardner et al.
CANCER RESEARCH (2014)
Most common 'sporadic' cancers have a significant germline genetic component
Yi Lu et al.
HUMAN MOLECULAR GENETICS (2014)
Genome-wide and single-cell analyses reveal a context dependent relationship between CBP recruitment and gene expression
Lawryn H. Kasper et al.
NUCLEIC ACIDS RESEARCH (2014)
Small Cell Lung Cancer: Therapies and Targets
Rathi N. Pillai et al.
SEMINARS IN ONCOLOGY (2014)
Global DNA Hypomethylation in Peripheral Blood Mononuclear Cells as a Biomarker of Cancer Risk
Simonetta Friso et al.
CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION (2013)
The fate is not always written in the genes: Epigenomics in epidemiologic studies
Scott M. Langevin et al.
ENVIRONMENTAL AND MOLECULAR MUTAGENESIS (2013)
A Phase II Study of the Histone Deacetylase Inhibitor Panobinostat (LBH589) in Pretreated Patients with Small-Cell Lung Cancer
Filippo de Marinis et al.
JOURNAL OF THORACIC ONCOLOGY (2013)
The significance of epigenetic alterations in lung carcinogenesis
Ewa Brzezianska et al.
MOLECULAR BIOLOGY REPORTS (2013)
DNA methylation dynamics in health and disease
Yehudit Bergman et al.
NATURE STRUCTURAL & MOLECULAR BIOLOGY (2013)
Safety and Tumor Responses with Lambrolizumab (Anti-PD-1) in Melanoma
Omid Hamid et al.
NEW ENGLAND JOURNAL OF MEDICINE (2013)
The DNA methylation landscape of small cell lung cancer suggests a differentiation defect of neuroendocrine cells
S. Kalari et al.
ONCOGENE (2013)
NeuroD1 regulates survival and migration of neuroendocrine lung carcinomas via signaling molecules TrkB and NCAM
Jihan K. Osborne et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2013)
H3K4 mono- and di-methyltransferase MLL4 is required for enhancer activation during cell differentiation
Ji-Eun Lee et al.
ELIFE (2013)
Caveolin-1 interferes cell growth of lung cancer NCI-H446 cell through the interactions with phospho-ERK1/2, estrogen receptor and progestin receptor
Ming-Zhong Sun et al.
BIOMEDICINE & PHARMACOTHERAPY (2012)
The role of EZH2 in tumour progression
C-J Chang et al.
BRITISH JOURNAL OF CANCER (2012)
Combination of HDAC and topoisomerase inhibitors in small cell lung cancer
Jhanelle Gray et al.
CANCER BIOLOGY & THERAPY (2012)
Higher Expression of Caveolin-1 Inhibits Human Small Cell Lung Cancer (SCLC) Apoptosis In Vitro
Xiaohan Yang et al.
CANCER INVESTIGATION (2012)
Phase II Trial of Temozolomide in Patients with Relapsed Sensitive or Refractory Small Cell Lung Cancer, with Assessment of Methylguanine- DNA Methyltransferase as a Potential Biomarker
M. Catherine Pietanza et al.
CLINICAL CANCER RESEARCH (2012)
Comprehensive genomic analysis identifies SOX2 as a frequently amplified gene in small-cell lung cancer
Charles M. Rudin et al.
NATURE GENETICS (2012)
Integrative genome analyses identify key somatic driver mutations of small-cell lung cancer
Martin Peifer et al.
NATURE GENETICS (2012)
Safety, Activity, and Immune Correlates of Anti-PD-1 Antibody in Cancer
Suzanne L. Topalian et al.
NEW ENGLAND JOURNAL OF MEDICINE (2012)
The Effect of Adenovirus-Mediated Gene Expression of FHIT in Small Cell Lung Cancer Cells
Roza Zandi et al.
CANCER INVESTIGATION (2011)
Lung Cancer: Epidemiology, Etiology, and Prevention
Charles S. Dela Cruz et al.
CLINICS IN CHEST MEDICINE (2011)
Nuclear factor I/B is an oncogene in small cell lung cancer
Alison L. Dooley et al.
GENES & DEVELOPMENT (2011)
Small-cell lung cancer
Jan P. van Meerbeeck et al.
LANCET (2011)
A continuum model for tumour suppression
Alice H. Berger et al.
NATURE (2011)
LSD1 regulates the balance between self-renewal and differentiation in human embryonic stem cells
Antonio Adamo et al.
NATURE CELL BIOLOGY (2011)
Ipilimumab plus Dacarbazine for Previously Untreated Metastatic Melanoma
Caroline Robert et al.
NEW ENGLAND JOURNAL OF MEDICINE (2011)
Epigenetic Modifications of Histone H4 in Lung Neuroendocrine Tumors
Faqian Li et al.
APPLIED IMMUNOHISTOCHEMISTRY & MOLECULAR MORPHOLOGY (2011)
Preclinical evidence for a beneficial impact of valproate on the response of small cell lung cancer to first-line chemotherapy
Roland Hubaux et al.
EUROPEAN JOURNAL OF CANCER (2010)
Histone demethylase KDM5A is an integral part of the core Notch-RBP-J repressor complex
Robert Liefke et al.
GENES & DEVELOPMENT (2010)
MYST Family Lysine Acetyltransferase Facilitates Ataxia Telangiectasia Mutated (ATM) Kinase-mediated DNA Damage Response in Toxoplasma gondii
Nathalie Vonlaufen et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2010)
Phase II Study of the Histone Deacetylase Inhibitor Romidepsin in Relapsed Small Cell Lung Cancer (Cancer and Leukemia Group B 30304)
Gregory A. Otterson et al.
JOURNAL OF THORACIC ONCOLOGY (2010)
Combinations of DNA Methyltransferase and Histone Deacetylase Inhibitors Induce DNA Damage in Small Cell Lung Cancer Cells: Correlation of Resistance with IFN-Stimulated Gene Expression
Wioleta Luszczek et al.
MOLECULAR CANCER THERAPEUTICS (2010)
Selective inhibition of BET bromodomains
Panagis Filippakopoulos et al.
NATURE (2010)
Improved Survival with Ipilimumab in Patients with Metastatic Melanoma
F. Stephen Hodi et al.
NEW ENGLAND JOURNAL OF MEDICINE (2010)
Achaete-Scute Complex Homologue 1 Regulates Tumor-Initiating Capacity in Human Small Cell Lung Cancer
Tianyun Jiang et al.
CANCER RESEARCH (2009)
Histone modifications at human enhancers reflect global cell-type-specific gene expression
Nathaniel D. Heintzman et al.
NATURE (2009)
Linking DNA methylation and histone modification: patterns and paradigms
Howard Cedar et al.
NATURE REVIEWS GENETICS (2009)
Epigenetic Cross-Talk between DNA Methylation and Histone Modifications in Human Cancers
Yutaka Kondo
YONSEI MEDICAL JOURNAL (2009)
Promoter hypermethylation of hallmark cancer genes in atypical adenomatous hyperplasia of the lung
Julien D. F. Licchesi et al.
CLINICAL CANCER RESEARCH (2008)
The HDAC inhibitor trichostatin A inhibits growth of small cell lung cancer cells
Christopher S. Platta et al.
JOURNAL OF SURGICAL RESEARCH (2007)
Global histone modifications predict prognosis of resected non-small-cell lung cancer
Fabrice Barlesi et al.
JOURNAL OF CLINICAL ONCOLOGY (2007)
Polycomb-mediated methylation on Lys27 of histone H3 pre-marks genes for de novo methylation in cancer
Yeshayahu Schlesinger et al.
NATURE GENETICS (2007)
A stem cell-like chromatin pattern may predispose tumor suppressor genes to DNA hypermethylation and heritable silencing
Joyce E. Ohm et al.
NATURE GENETICS (2007)
Loss of tumor suppressor PTEN function increases B7-H1 expression and immunoresistance in glioma
Andrew T. Parsa et al.
NATURE MEDICINE (2007)
Crystal structure of human histone lysine-specific demethylase 1 (LSD1)
Yong Chen et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2006)
Structural basis for CoREST-dependent demethylation of nucleosomes by the human LSD1 histone demethylase
Maojun Yang et al.
MOLECULAR CELL (2006)
Epigenetic regulation of the tumor suppressor gene, TCF21 on 6q23-q24 in lung and head and neck cancer
LT Smith et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2006)
Histone demethylation mediated by the nuclear arnine oxidase homolog LSD1
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CELL (2004)
Mechanisms of disease: Gene silencing in cancer in association with promoter hypermethylation
JG Herman et al.
NEW ENGLAND JOURNAL OF MEDICINE (2003)
EZH2 is downstream of the pRB-E2F pathway, essential for proliferation and amplified in cancer
AP Bracken et al.
EMBO JOURNAL (2003)
MYC recruits the TIP60 histone acetyltransferase complex to chromatin
SR Frank et al.
EMBO REPORTS (2003)
Stimulation of c-MYC transcriptional activity and acetylation by recruitment of the cofactor CBP
J Vervoorts et al.
EMBO REPORTS (2003)
Silencing of death receptor and caspase-8 expression in small cell lung carcinoma cell lines and tumors by DNA methylation
S Hopkins-Donaldson et al.
CELL DEATH AND DIFFERENTIATION (2003)
cDNA cloning of the human polybromo-1 gene on chromosome 3p21
I Horikawa et al.
DNA SEQUENCE (2002)
Epigenetic inactivation of RASSF14 in lung and breast cancers and malignant phenotype suppression
DG Burbee et al.
JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE (2001)
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