4.6 Article

Dysregulated FOXM1 signaling in the regulation of cancer stem cells

相关参考文献

注意:仅列出部分参考文献,下载原文获取全部文献信息。
Article Oncology

Cancer statistics, 2022

Rebecca L. Siegel et al.

Summary: Each year, the American Cancer Society compiles data on cancer occurrence and outcomes in the United States. The latest data shows that breast and prostate cancer progress has stagnated, while lung cancer has shown improvements in survival rates. Lung cancer incidence for advanced disease has declined while localized-stage rates have increased, resulting in higher survival rates. Mortality patterns align with incidence trends, with lung cancer deaths declining rapidly, breast cancer deaths slowing, and prostate cancer deaths stabilizing.

CA-A CANCER JOURNAL FOR CLINICIANS (2022)

Article Biochemistry & Molecular Biology

FOXM1 mediates GDF-15 dependent stemness and intrinsic drug resistance in breast cancer

Anupama Modi et al.

Summary: Stemness and drug resistance in breast cancer (BC) can be promoted by growth differentiation factor-15 (GDF-15) through the p-AKT/FOXM1 axis. This study found that GDF-15 is significantly elevated in BC patients and is associated with the expression of stemness and drug resistance markers.

MOLECULAR BIOLOGY REPORTS (2022)

Article Oncology

Dinaciclib inhibits the stemness of two subtypes of human breast cancer cells by targeting the FoxM1 and Hedgehog signaling pathway

Ai-Ni Tsao et al.

Summary: CDK4/6 inhibitors combined with endocrine therapy are the standard treatment for breast cancer. However, CDKs have potential roles beyond cell cycle regulation. Dinaciclib, a CDK inhibitor, inhibits breast cancer stemness and shows potential for future cancer treatment.

ONCOLOGY REPORTS (2022)

Review Oncology

O-GlcNAc Transferase - An Auxiliary Factor or a Full-blown Oncogene?

Harri M. Itkonen et al.

Summary: OGT enzyme is involved in the posttranslational modification of serine and threonine residues, and its increased expression is a common feature in most human cancers. Inhibition of OGT reduces cancer cell proliferation by affecting known regulators of cancer cell proliferation. While OGT has potential in cancer therapy, further understanding of its substrate specificity and development of more specific inhibitors are needed.

MOLECULAR CANCER RESEARCH (2021)

Article Medicine, General & Internal

Hepatocellular carcinoma

Josep M. Llovet et al.

Summary: Liver cancer, particularly hepatocellular carcinoma (HCC), poses a significant global health challenge with rising incidence projected to exceed 1 million cases by 2025. Infection by hepatitis B and C viruses remains a major risk factor for HCC, while non-alcoholic steatohepatitis is emerging as a more common risk factor in Western countries. Advances in systemic therapies for HCC, including immunotherapies and targeted therapies, are expected to revolutionize the management of this disease.

NATURE REVIEWS DISEASE PRIMERS (2021)

Article Oncology

Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries

Hyuna Sung et al.

Summary: The global cancer burden in 2020 saw an estimated 19.3 million new cancer cases and almost 10.0 million cancer deaths. Female breast cancer surpassed lung cancer as the most commonly diagnosed cancer, while lung cancer remained the leading cause of cancer death. These trends are expected to rise in 2040, with transitioning countries experiencing a larger increase compared to transitioned countries due to demographic changes and risk factors associated with globalization and a growing economy. Efforts to improve cancer prevention measures and provision of cancer care in transitioning countries will be crucial for global cancer control.

CA-A CANCER JOURNAL FOR CLINICIANS (2021)

Review Medicine, General & Internal

Diagnosis and Treatment of Metastatic Colorectal Cancer: A Review

Leah H. Biller et al.

Summary: Colorectal cancer is the third most common cause of cancer mortality worldwide. For patients diagnosed with metastatic colorectal cancer, approximately 70% to 75% can survive beyond 1 year. Tailoring treatments based on the molecular and pathologic features of the tumor has shown to improve overall survival rates.

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION (2021)

Article Cell Biology

Requirement of transcription factor NME2 for the maintenance of the stemness of gastric cancer stem-like cells

Yaxin Qi et al.

Summary: The transcription factor NME2 plays a crucial role in maintaining the stemness of gastric cancer stem cells by suppressing apoptosis and enhancing the expression of anti-apoptosis genes. This study provides a new perspective on the relationship between transcription factors and the stemness maintenance of gastric cancer stem cells.

CELL DEATH & DISEASE (2021)

Article Oncology

Pancreatic cancer stem cells may define tumor stroma characteristics and recurrence patterns in pancreatic ductal adenocarcinoma

Gokce Askan et al.

Summary: The study found that the expression of CD44 and ESA in PDAC patients is related to tumor stroma type, and tumor stroma may influence recurrence patterns, but there was no significant difference among subgroups in terms of RFS and OS.

BMC CANCER (2021)

Review Oncology

Emerging agents that target signaling pathways to eradicate colorectal cancer stem cells

Valdenizia R. Silva et al.

Summary: This review outlines strategies for eradicating CRC stem cells by modulating dysregulated pathways, with the aim of enhancing potential therapeutic schemes through the combination of conventional drugs and CSC-targeting drugs, leading to improved cure rates in anti-CRC therapy.

CANCER COMMUNICATIONS (2021)

Review Medicine, General & Internal

What Is New on Ovarian Carcinoma: Integrated Morphologic and Molecular Analysis Following the New 2020 World Health Organization Classification of Female Genital Tumors

Antonio De Leo et al.

Summary: Ovarian carcinomas are a heterogeneous group of neoplasms with different types and characteristics. The WHO classifies them into five distinct types, each with unique molecular features. Advances in molecular pathology have improved our understanding of ovarian carcinomas and can guide personalized clinical decisions.

DIAGNOSTICS (2021)

Review Oncology

The plasticity of pancreatic cancer stem cells: implications in therapeutic resistance

Kalyani Patil et al.

Summary: This review delves into the characteristics of pancreatic cancer stem cells, the mechanisms of treatment failure, and the increasingly popular natural agents targeting stem cells. Understanding the molecular and functional features of stem cells' resistance to chemotherapy in pancreatic cancer presents an opportunity for treatment.

CANCER AND METASTASIS REVIEWS (2021)

Article Multidisciplinary Sciences

Epidemiology, treatment, and survival in small cell lung cancer in Spain: Data from the Thoracic Tumor Registry

Fernando Franco et al.

Summary: Background Small-cell lung cancer (SCLC) is an aggressive disease with high metastatic potential and poor prognosis. This observational multicenter study in Spain provides an updated overview of the clinical situation and treatment landscape of ES-SCLC, revealing higher mortality and progression rates associated with male sex, older age, smoking habit, and ECOG PS 1-2, and a small percentage of patients achieving long-term survival.

PLOS ONE (2021)

Review Oncology

Gastric Cancer Stem Cells: A Glimpse on Metabolic Reprogramming

Martina Addeo et al.

Summary: Gastric cancer stem cells play a crucial role in the initiation and progression of gastric cancer, with features like self-renewal capability and resistance to current anticancer therapies. Targeting metabolic pathways of cancer stem cells could be a promising strategy in cancer therapy.

FRONTIERS IN ONCOLOGY (2021)

Review Cell Biology

Cancer Stem Cells: Emerging Key Players in Immune Evasion of Cancers

Martina Mang Leng Lei et al.

Summary: Immune cells play a crucial role in driving cancer cells towards stemness and enabling cancer stem cells to evade immune surveillance by affecting various immune cells in the tumor microenvironment. Targeting CSCs with immunotherapy disrupts the interaction between immune cells and CSCs, offering a novel strategy against cancer.

FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY (2021)

Review Immunology

The inflammatory pathogenesis of colorectal cancer

Mark Schmitt et al.

Summary: The research on colorectal cancer indicates the importance of an inflammatory microenvironment for tumorigenesis, which influences the activation of immune cells and stromal cells, as well as the role of intestinal microbiome in tumor development. Chronic inflammation can initiate tumorigenesis, and tumor-elicited and therapy-induced inflammation are also implicated in promoting colorectal cancer.

NATURE REVIEWS IMMUNOLOGY (2021)

Article Biochemistry & Molecular Biology

Downregulation of FOXO3a by DNMT1 promotes breast cancer stem cell properties and tumorigenesis

Hao Liu et al.

CELL DEATH AND DIFFERENTIATION (2020)

Review Gastroenterology & Hepatology

Burden of Gastric Cancer

Aaron P. Thrift et al.

CLINICAL GASTROENTEROLOGY AND HEPATOLOGY (2020)

Review Cell Biology

Cancer stem cells: A review from origin to therapeutic implications

Mohammad Reza Atashzar et al.

JOURNAL OF CELLULAR PHYSIOLOGY (2020)

Article Oncology

Colorectal cancer statistics, 2020

Rebecca L. Siegel et al.

CA-A CANCER JOURNAL FOR CLINICIANS (2020)

Review Cell Biology

'Omics Approaches to Explore the Breast Cancer Landscape

Joseph Parsons et al.

FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY (2020)

Article Biochemistry & Molecular Biology

FOXM1 facilitates breast cancer cell stemness and migration in YAP1-dependent manner

Hong-Liang Sun et al.

ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS (2020)

Review Oncology

Cancer stemness in hepatocellular carcinoma: mechanisms and translational potential

Yu-Man Tsui et al.

BRITISH JOURNAL OF CANCER (2020)

Article Oncology

The DNMT1/miR-34a/FOXM1 Axis Contributes to Stemness of Liver Cancer Cells

Xiaocheng Cao et al.

JOURNAL OF ONCOLOGY (2020)

Review Oncology

Therapeutic Targeting of Signaling Pathways Related to Cancer Stemness

Asuncion Espinosa-Sanchez et al.

FRONTIERS IN ONCOLOGY (2020)

Article Cell Biology

FZD5 contributes to TNBC proliferation, DNA damage repair and stemness

Yu Sun et al.

CELL DEATH & DISEASE (2020)

Review Biochemistry & Molecular Biology

Targeting cancer stem cell pathways for cancer therapy

Liqun Yang et al.

SIGNAL TRANSDUCTION AND TARGETED THERAPY (2020)

Article Oncology

FOXM1 promotes hepatocellular carcinoma progression by regulating KIF4A expression

Guohui Hu et al.

JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH (2019)

Review Cell & Tissue Engineering

Cancer Stem Cells: Acquisition, Characteristics, Therapeutic Implications, Targeting Strategies and Future Prospects

Anoop K. Yadav et al.

STEM CELL REVIEWS AND REPORTS (2019)

Article Cell Biology

WDR76 degrades RAS and suppresses cancer stem cell activation in colorectal cancer

Eun Ji Ro et al.

CELL COMMUNICATION AND SIGNALING (2019)

Review Cell Biology

Cancer stem cells (CSCs) in cancer progression and therapy

Masoud Najafi et al.

JOURNAL OF CELLULAR PHYSIOLOGY (2019)

Review Cell Biology

Meeting the Challenge of Targeting Cancer Stem Cells

Alice Turdo et al.

FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY (2019)

Article Biochemistry & Molecular Biology

Disruption of crosstalk between LX-2 and liver cancer stem-like cells from MHCC97H cells by DFOG via inhibiting FOXM1

A. Chen et al.

ACTA BIOCHIMICA ET BIOPHYSICA SINICA (2019)

Article Biochemistry & Molecular Biology

The inhibitory effect of 5,7-DMF on pancreatic sphere-forming cell function mediated by FoxM1 gene expression

Deyu Zeng et al.

JOURNAL OF CELLULAR BIOCHEMISTRY (2018)

Article Biochemistry & Molecular Biology

FOXM1 promotes proliferation in human hepatocellular carcinoma cells by transcriptional activation of CCNB1

Na Chai et al.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2018)

Review Biotechnology & Applied Microbiology

The role of Hippo signal pathway in breast cancer metastasis

Changran Wei et al.

ONCOTARGETS AND THERAPY (2018)

Article Obstetrics & Gynecology

Pathology of cancers of the female genital tract including molecular pathology

Jaime Prat et al.

INTERNATIONAL JOURNAL OF GYNECOLOGY & OBSTETRICS (2018)

Article Biochemistry & Molecular Biology

A gene expression signature of FOXM1 predicts the prognosis of hepatocellular carcinoma

Bic-Na Song et al.

EXPERIMENTAL AND MOLECULAR MEDICINE (2018)

Review Cell Biology

Cancer stem cells as key drivers of tumour progression

Ain Zubaidah Ayob et al.

JOURNAL OF BIOMEDICAL SCIENCE (2018)

Article Urology & Nephrology

On a FOX hunt: functions of FOX transcriptional regulators in bladder cancer

Hironobu Yamashita et al.

NATURE REVIEWS UROLOGY (2017)

Review Biochemistry & Molecular Biology

Ovarian cancer stem cells: still an elusive entity?

Michela Lupia et al.

MOLECULAR CANCER (2017)

Article Biochemistry & Molecular Biology

Regulation of the Hippo-YAP Pathway by Glucose Sensor O-GlcNAcylation

Changmin Peng et al.

MOLECULAR CELL (2017)

Review Biochemistry & Molecular Biology

Cancer stem cells revisited

Eduard Batlle et al.

NATURE MEDICINE (2017)

Review Oncology

Role of tumor microenvironment in tumorigenesis

Maonan Wang et al.

JOURNAL OF CANCER (2017)

Article Oncology

FOXM1 transcriptionally regulates expression of integrin β1 in triple-negative breast cancer

Zuhal Hamurcu et al.

BREAST CANCER RESEARCH AND TREATMENT (2017)

Article Developmental Biology

Fox transcription factors: from development to disease

Maria L. Golson et al.

DEVELOPMENT (2016)

Review Medicine, General & Internal

Cancer stem cell signaling pathways

William H. Matsui

MEDICINE (2016)

Article Medicine, General & Internal

Ovarian cancer

Ursula A. Matulonis et al.

NATURE REVIEWS DISEASE PRIMERS (2016)

Review Multidisciplinary Sciences

Fundamentals of cancer metabolism

Ralph J. DeBerardinis et al.

SCIENCE ADVANCES (2016)

Article Oncology

Glioblastoma: Overview of Disease and Treatment

Mary Elizabeth Davis

CLINICAL JOURNAL OF ONCOLOGY NURSING (2016)

Article Biochemistry & Molecular Biology

Crucial role of HMGA1 in the self-renewal and drug resistance of ovarian cancer stem cells

Dae Kyoung Kim et al.

EXPERIMENTAL AND MOLECULAR MEDICINE (2016)

Article Cell Biology

The emerging roles of Oct4 in tumor-initiating cells

Ying-Jie Wang et al.

AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY (2015)

Editorial Material Biochemistry & Molecular Biology

Mitochondrial metabolism in cancer stem cells: a therapeutic target for colon cancer

In-Sung Song et al.

BMB REPORTS (2015)

Article Pharmacology & Pharmacy

Glioblastoma Multiforme Formation and EMT: Role of FoxM1 Transcription Factor

Zhongyong Wang et al.

CURRENT PHARMACEUTICAL DESIGN (2015)

Article Gastroenterology & Hepatology

Essential roles of FoxM1 in Ras-induced liver cancer progression and in cancer cells with stem cell features

Dragana Kopanja et al.

JOURNAL OF HEPATOLOGY (2015)

Review Oncology

FOXM1 and its Oncogenic Signaling in Gastric Cancer

Hanying Wang et al.

RECENT PATENTS ON ANTI-CANCER DRUG DISCOVERY (2015)

Article Cell & Tissue Engineering

Common stemness regulators of embryonic and cancer stem cells

Christiana Hadjimichael et al.

WORLD JOURNAL OF STEM CELLS (2015)

Review Biochemistry & Molecular Biology

Lung Cancer Stem Cells and Implications for Future Therapeutics

Jing Wang et al.

CELL BIOCHEMISTRY AND BIOPHYSICS (2014)

Review Cell & Tissue Engineering

Colorectal Cancer Stem Cells: From the Crypt to the Clinic

Ann Zeuner et al.

CELL STEM CELL (2014)

Article Oncology

FOXM1 Regulated by ERK Pathway Mediates TGF-β1-Induced EMT in NSCLC

Fei-Fei Kong et al.

ONCOLOGY RESEARCH (2014)

Article Multidisciplinary Sciences

O-GlcNAcylation regulates EZH2 protein stability and function

Chi-Shuen Chu et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2014)

Review Oncology

FOXM1: A key oncofoetal transcription factor in health and disease

Laura Bella et al.

SEMINARS IN CANCER BIOLOGY (2014)

Review Oncology

Cancer genetics and genomics of human FOX family genes

Masuko Katoh et al.

CANCER LETTERS (2013)

Review Medicine, General & Internal

Glioblastoma and Other Malignant Gliomas A Clinical Review

Antonio Omuro et al.

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION (2013)

Article Biochemistry & Molecular Biology

Hyper-O-GlcNAcylation Is Anti-apoptotic and Maintains Constitutive NF-κB Activity in Pancreatic Cancer Cells

Zhiyuan Ma et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2013)

Review Medicine, Research & Experimental

Cancer stem cells in the development of liver cancer

Taro Yamashita et al.

JOURNAL OF CLINICAL INVESTIGATION (2013)

Review Biochemistry & Molecular Biology

The roles of FOXM1 in pancreatic stem cells and carcinogenesis

Ming Quan et al.

MOLECULAR CANCER (2013)

Article Cell Biology

Cancer stem cells: The challenges ahead

Jan Paul Medema

NATURE CELL BIOLOGY (2013)

Article Cell & Tissue Engineering

MELK-Dependent FOXM1 Phosphorylation is Essential for Proliferation of Glioma Stem Cells

Kaushal Joshi et al.

STEM CELLS (2013)

Review Oncology

FoxM1 and Wnt/β-Catenin Signaling in Glioma Stem Cells

Aihua Gong et al.

CANCER RESEARCH (2012)

Review Oncology

Cancer stem cells hypothesis and stem cells in head and neck cancers

Giuditta Mannelli et al.

CANCER TREATMENT REVIEWS (2012)

Article Oncology

CD44+/CD24-ovarian cancer cells demonstrate cancer stem cell properties and correlate to survival

Erhong Meng et al.

CLINICAL & EXPERIMENTAL METASTASIS (2012)

Article Hematology

Overexpression of FoxM1 offers a promising therapeutic target in diffuse large B-cell lymphoma

Shahab Uddin et al.

HAEMATOLOGICA-THE HEMATOLOGY JOURNAL (2012)

Article Endocrinology & Metabolism

FoxM1 and Its Association with Matrix Metalloproteinases (MMP) Signaling Pathway in Papillary Thyroid Carcinoma

Maqbool Ahmed et al.

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM (2012)

Article Pathology

CD133 expression associated with poor prognosis in ovarian cancer

Jing Zhang et al.

MODERN PATHOLOGY (2012)

Review Pathology

Molecular Genetics of Colorectal Cancer

Eric R. Fearon

ANNUAL REVIEW OF PATHOLOGY: MECHANISMS OF DISEASE, VOL 6 (2011)

Article Biochemistry & Molecular Biology

Glioma Stem Cell Proliferation and Tumor Growth Are Promoted by Nitric Oxide Synthase-2

Christine E. Eyler et al.

Editorial Material Cell & Tissue Engineering

Not So Lonely at the Top for Cancer Stem Cells

Ann Zeuner et al.

CELL STEM CELL (2011)

Article Cell & Tissue Engineering

The Intestinal Stem Cell Signature Identifies Colorectal Cancer Stem Cells and Predicts Disease Relapse

Anna Merlos-Suarez et al.

CELL STEM CELL (2011)

Article Multidisciplinary Sciences

Integrated genomic analyses of ovarian carcinoma

D. Bell et al.

NATURE (2011)

Article Multidisciplinary Sciences

Tumor-initiating stem cells of squamous cell carcinomas and their control by TGF-β and integrin/focal adhesion kinase (FAK) signaling

Markus Schober et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2011)

Review Genetics & Heredity

Forkhead transcription factors: key players in health and disease

Berenice A. Benayoun et al.

TRENDS IN GENETICS (2011)

Review Gastroenterology & Hepatology

Epigenetic regulation of cancer stem cells in liver cancer: Current concepts and clinical implications

J. U. Marquardt et al.

JOURNAL OF HEPATOLOGY (2010)

Article Oncology

Driver mutations in TP53 are ubiquitous in high grade serous carcinoma of the ovary

Ashour Ahmed Ahmed et al.

JOURNAL OF PATHOLOGY (2010)

Article Biochemistry & Molecular Biology

Foxm1 transcription factor is required for maintenance of pluripotency of P19 embryonal carcinoma cells

Zhongqiu Xie et al.

NUCLEIC ACIDS RESEARCH (2010)

Article Biochemistry & Molecular Biology

Targeting A20 Decreases Glioma Stem Cell Survival and Tumor Growth

Anita B. Hjelmeland et al.

PLOS BIOLOGY (2010)

Review Medicine, Research & Experimental

Hedgehog Target Genes: Mechanisms of Carcinogenesis Induced by Aberrant Hedgehog Signaling Activation

Y. Katoh et al.

CURRENT MOLECULAR MEDICINE (2009)

Article Multidisciplinary Sciences

Crypt stem cells as the cells-of-origin of intestinal cancer

Nick Barker et al.

NATURE (2009)

Article Multidisciplinary Sciences

Diversity and Complexity in DNA Recognition by Transcription Factors

Gwenael Badis et al.

SCIENCE (2009)

Article Biochemistry & Molecular Biology

An N-terminal inhibitory domain modulates activity of FoxM1 during cell cycle

H. J. Park et al.

ONCOGENE (2008)

Review Medicine, Research & Experimental

Breast cancer: origins and evolution

Kornelia Polyak

JOURNAL OF CLINICAL INVESTIGATION (2007)

Review Oncology

The emerging roles of forkhead box (Fox) proteins in cancer

Stephen S. Myatt et al.

NATURE REVIEWS CANCER (2007)

Article Multidisciplinary Sciences

Horizontal transfer of oncogenes by uptake of apoptotic bodies

A Bergsmedh et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2001)

Article Multidisciplinary Sciences

Molecular portraits of human breast tumours

CM Perou et al.

NATURE (2000)